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- W289629025 abstract "Abstract Aim To investigate the effect of tanshinone IIA on adiponectin biosynthesis. Methods The differentiation state of 3T3-L1 adipocytes was checked by Oil Red O staining. mRNA levels were examined by real-time PCR. Adiponectin oligomers were subjected to 2%–15% gradient SDS-PAGE and then detected using western blotting. Gene silencing experiments were performed using standard siRNA methods. Results It was found that tanshinone IIA, a diterpenoid naphthoquinone from the Chinese traditional herb Danshen ( Salvia miltiorrhiza ), inhibited the differentiation of preadipocytes and down-regulated the expression of adiponectin. In contrast, tanshinone IIA promoted the assembly of high-molecular weight (HMW) adiponectin during differentiation and in mature adipocytes. Tanshinone IIA activated AMP-activated protein kinase (AMPK) in 3T3-L1 adipocytes, and suppression of the AMPK pathway blocked the effect of tanshinone IIA on adiponectin expression and multimerization. Conclusion These data suggest that tanshinone IIA promotes the assembly of HMW adiponectin through a process involving AMPK activation." @default.
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- W289629025 date "2012-09-04" @default.
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- W289629025 title "Tanshinone IIA promotes the assembly of adiponectin in 3T3-L1 adipocytes" @default.
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- W289629025 doi "https://doi.org/10.3724/sp.j.1009.2012.00150" @default.
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