FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896315430> ?p ?o ?g. }

• W2896315430 endingPage "1682" @default.
• W2896315430 startingPage "1682" @default.
• W2896315430 abstract "<ns5:p>Cancer metastasis is the most important prognostic factor determining patient survival, but currently there are very few drugs or therapies that specifically inhibit the invasion and metastasis of cancer cells. Currently, human cancer metastasis is largely studied using transgenic and immunocompromised mouse xenograft models, which are useful for analysing end-point tumour growth but are unable to accurately and reliably monitor <ns5:italic>in vivo</ns5:italic> invasion, intravasation, extravasation or secondary tumour formation of human cancer cells. Furthermore, limits in our ability to accurately monitor early stages of tumour growth and detect micro-metastases likely results in pain and suffering to the mice used for cancer xenograft experiments. Zebrafish (<ns5:italic>Danio rerio</ns5:italic>) embryos, however, offer many advantages as a model system for studying the complex, multi-step processes involved during cancer metastasis. This article describes a detailed method for the analysis of human cancer cell invasion and metastasis in zebrafish embryos before they reach protected status at 5 days post fertilisation. Results demonstrate that human cancer cells actively invade within a zebrafish microenvironment, and form metastatic tumours at secondary tissue sites, suggesting that the mechanisms involved during the different stages of metastasis are conserved between humans and zebrafish, supporting the use of zebrafish embryos as a viable model of human cancer metastasis. We suggest that the embryonic zebrafish xenograft model of human cancer is a tractable laboratory model that can be used to understand cancer biology, and as a direct replacement of mice for the analysis of drugs that target cancer invasion and metastasis.</ns5:p>" @default.
• W2896315430 created "2018-10-26" @default.
• W2896315430 creator A5022682253 @default.
• W2896315430 creator A5056683269 @default.
• W2896315430 creator A5067583640 @default.
• W2896315430 creator A5084525017 @default.
• W2896315430 date "2018-12-20" @default.
• W2896315430 modified "2023-10-14" @default.
• W2896315430 title "Embryonic zebrafish xenograft assay of human cancer metastasis" @default.
• W2896315430 cites W1041986708 @default.
• W2896315430 cites W1190089084 @default.
• W2896315430 cites W1536415439 @default.
• W2896315430 cites W1560901631 @default.
• W2896315430 cites W1846094258 @default.
• W2896315430 cites W1966245674 @default.
• W2896315430 cites W1976766117 @default.
• W2896315430 cites W1981239255 @default.
• W2896315430 cites W1983153151 @default.
• W2896315430 cites W1986471913 @default.
• W2896315430 cites W1998261391 @default.
• W2896315430 cites W2012672965 @default.
• W2896315430 cites W2017452459 @default.
• W2896315430 cites W2026815880 @default.
• W2896315430 cites W2032982849 @default.
• W2896315430 cites W2048630989 @default.
• W2896315430 cites W2057151160 @default.
• W2896315430 cites W2067829376 @default.
• W2896315430 cites W2074125844 @default.
• W2896315430 cites W2080173566 @default.
• W2896315430 cites W2082833890 @default.
• W2896315430 cites W2099345094 @default.
• W2896315430 cites W2099760403 @default.
• W2896315430 cites W2106787323 @default.
• W2896315430 cites W2124881596 @default.
• W2896315430 cites W2130867650 @default.
• W2896315430 cites W2133976778 @default.
• W2896315430 cites W2134408326 @default.
• W2896315430 cites W2142162357 @default.
• W2896315430 cites W2148110870 @default.
• W2896315430 cites W2149324586 @default.
• W2896315430 cites W2162755712 @default.
• W2896315430 cites W2167661193 @default.
• W2896315430 cites W2170096833 @default.
• W2896315430 cites W2234510958 @default.
• W2896315430 cites W2263255358 @default.
• W2896315430 cites W2344628383 @default.
• W2896315430 cites W2559994421 @default.
• W2896315430 cites W2563661701 @default.
• W2896315430 cites W2577286195 @default.
• W2896315430 cites W2577408658 @default.
• W2896315430 cites W2748052555 @default.
• W2896315430 cites W2751023845 @default.
• W2896315430 cites W2806413494 @default.
• W2896315430 cites W2896534701 @default.
• W2896315430 cites W2900001116 @default.
• W2896315430 doi "https://doi.org/10.12688/f1000research.16659.2" @default.
• W2896315430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6234738" @default.
• W2896315430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30473782" @default.
• W2896315430 hasPublicationYear "2018" @default.
• W2896315430 type Work @default.
• W2896315430 sameAs 2896315430 @default.
• W2896315430 citedByCount "29" @default.
• W2896315430 countsByYear W28963154302019 @default.
• W2896315430 countsByYear W28963154302020 @default.
• W2896315430 countsByYear W28963154302021 @default.
• W2896315430 countsByYear W28963154302022 @default.
• W2896315430 crossrefType "journal-article" @default.
• W2896315430 hasAuthorship W2896315430A5022682253 @default.
• W2896315430 hasAuthorship W2896315430A5056683269 @default.
• W2896315430 hasAuthorship W2896315430A5067583640 @default.
• W2896315430 hasAuthorship W2896315430A5084525017 @default.
• W2896315430 hasBestOaLocation W28963154301 @default.
• W2896315430 hasConcept C104317684 @default.
• W2896315430 hasConcept C121608353 @default.
• W2896315430 hasConcept C142724271 @default.
• W2896315430 hasConcept C145103041 @default.
• W2896315430 hasConcept C2776878037 @default.
• W2896315430 hasConcept C2778050619 @default.
• W2896315430 hasConcept C2779013556 @default.
• W2896315430 hasConcept C2780384893 @default.
• W2896315430 hasConcept C2780394083 @default.
• W2896315430 hasConcept C502942594 @default.
• W2896315430 hasConcept C54355233 @default.
• W2896315430 hasConcept C71924100 @default.
• W2896315430 hasConcept C86803240 @default.
• W2896315430 hasConcept C96232424 @default.
• W2896315430 hasConceptScore W2896315430C104317684 @default.
• W2896315430 hasConceptScore W2896315430C121608353 @default.
• W2896315430 hasConceptScore W2896315430C142724271 @default.
• W2896315430 hasConceptScore W2896315430C145103041 @default.
• W2896315430 hasConceptScore W2896315430C2776878037 @default.
• W2896315430 hasConceptScore W2896315430C2778050619 @default.
• W2896315430 hasConceptScore W2896315430C2779013556 @default.
• W2896315430 hasConceptScore W2896315430C2780384893 @default.
• W2896315430 hasConceptScore W2896315430C2780394083 @default.
• W2896315430 hasConceptScore W2896315430C502942594 @default.
• W2896315430 hasConceptScore W2896315430C54355233 @default.
• W2896315430 hasConceptScore W2896315430C71924100 @default.

• next