FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896317215> ?p ?o ?g. }

• W2896317215 endingPage "851.e4" @default.
• W2896317215 startingPage "841" @default.
• W2896317215 abstract "The GluN2 subtype (2A versus 2B) determines biophysical properties and signaling of forebrain NMDA receptors (NMDARs). During development, GluN2A becomes incorporated into previously GluN2B-dominated NMDARs. This “switch” is proposed to be driven by distinct features of GluN2 cytoplasmic C-terminal domains (CTDs), including a unique CaMKII interaction site in GluN2B that drives removal from the synapse. However, these models remain untested in the context of endogenous NMDARs. We show that, although mutating the endogenous GluN2B CaMKII site has secondary effects on GluN2B CTD phosphorylation, the developmental changes in NMDAR composition occur normally and measures of plasticity and synaptogenesis are unaffected. Moreover, the switch proceeds normally in mice that have the GluN2A CTD replaced by that of GluN2B and commences without an observable decline in GluN2B levels but is impaired by GluN2A haploinsufficiency. Thus, GluN2A expression levels, and not GluN2 subtype-specific CTD-driven events, are the overriding factor in the developmental switch in NMDAR composition." @default.
• W2896317215 created "2018-10-26" @default.
• W2896317215 creator A5006025723 @default.
• W2896317215 creator A5014593722 @default.
• W2896317215 creator A5014681613 @default.
• W2896317215 creator A5019090318 @default.
• W2896317215 creator A5021351853 @default.
• W2896317215 creator A5021509895 @default.
• W2896317215 creator A5022950217 @default.
• W2896317215 creator A5039722428 @default.
• W2896317215 creator A5044428518 @default.
• W2896317215 creator A5046203888 @default.
• W2896317215 creator A5052972851 @default.
• W2896317215 creator A5059996026 @default.
• W2896317215 creator A5078796496 @default.
• W2896317215 creator A5081949745 @default.
• W2896317215 creator A5084280682 @default.
• W2896317215 date "2018-10-01" @default.
• W2896317215 modified "2023-10-13" @default.
• W2896317215 title "The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences" @default.
• W2896317215 cites W1558650798 @default.
• W2896317215 cites W1770011866 @default.
• W2896317215 cites W1796178200 @default.
• W2896317215 cites W1823204572 @default.
• W2896317215 cites W1849415743 @default.
• W2896317215 cites W1888844436 @default.
• W2896317215 cites W1961997323 @default.
• W2896317215 cites W1965167390 @default.
• W2896317215 cites W1975964041 @default.
• W2896317215 cites W1991449336 @default.
• W2896317215 cites W1994732950 @default.
• W2896317215 cites W2008249867 @default.
• W2896317215 cites W2008763819 @default.
• W2896317215 cites W2008768196 @default.
• W2896317215 cites W2009307312 @default.
• W2896317215 cites W2011219963 @default.
• W2896317215 cites W2017241296 @default.
• W2896317215 cites W2020509501 @default.
• W2896317215 cites W2024380057 @default.
• W2896317215 cites W2028329394 @default.
• W2896317215 cites W2029568863 @default.
• W2896317215 cites W2030868502 @default.
• W2896317215 cites W2041024256 @default.
• W2896317215 cites W2042295311 @default.
• W2896317215 cites W2047451186 @default.
• W2896317215 cites W2053361108 @default.
• W2896317215 cites W2053700159 @default.
• W2896317215 cites W2064111585 @default.
• W2896317215 cites W2064758852 @default.
• W2896317215 cites W2068225015 @default.
• W2896317215 cites W2069783754 @default.
• W2896317215 cites W2076090607 @default.
• W2896317215 cites W2096562774 @default.
• W2896317215 cites W2099582878 @default.
• W2896317215 cites W2102508455 @default.
• W2896317215 cites W2108488213 @default.
• W2896317215 cites W2108909652 @default.
• W2896317215 cites W2124023477 @default.
• W2896317215 cites W2127360976 @default.
• W2896317215 cites W2129435019 @default.
• W2896317215 cites W2133000126 @default.
• W2896317215 cites W2133259993 @default.
• W2896317215 cites W2141911467 @default.
• W2896317215 cites W2143634891 @default.
• W2896317215 cites W2145547868 @default.
• W2896317215 cites W2146521940 @default.
• W2896317215 cites W2149462562 @default.
• W2896317215 cites W2153203146 @default.
• W2896317215 cites W2168888447 @default.
• W2896317215 cites W2176816948 @default.
• W2896317215 cites W2195293395 @default.
• W2896317215 cites W2234053937 @default.
• W2896317215 cites W2324655359 @default.
• W2896317215 cites W2344874345 @default.
• W2896317215 cites W2471976579 @default.
• W2896317215 cites W2611496024 @default.
• W2896317215 cites W2736433134 @default.
• W2896317215 cites W2804368056 @default.
• W2896317215 cites W292451388 @default.
• W2896317215 doi "https://doi.org/10.1016/j.celrep.2018.09.089" @default.
• W2896317215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6218242" @default.
• W2896317215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30355491" @default.
• W2896317215 hasPublicationYear "2018" @default.
• W2896317215 type Work @default.
• W2896317215 sameAs 2896317215 @default.
• W2896317215 citedByCount "26" @default.
• W2896317215 countsByYear W28963172152019 @default.
• W2896317215 countsByYear W28963172152020 @default.
• W2896317215 countsByYear W28963172152021 @default.
• W2896317215 countsByYear W28963172152022 @default.
• W2896317215 countsByYear W28963172152023 @default.
• W2896317215 crossrefType "journal-article" @default.
• W2896317215 hasAuthorship W2896317215A5006025723 @default.
• W2896317215 hasAuthorship W2896317215A5014593722 @default.
• W2896317215 hasAuthorship W2896317215A5014681613 @default.
• W2896317215 hasAuthorship W2896317215A5019090318 @default.
• W2896317215 hasAuthorship W2896317215A5021351853 @default.
• W2896317215 hasAuthorship W2896317215A5021509895 @default.

• next