Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896340470> ?p ?o ?g. }
- W2896340470 abstract "Abstract Taxonomic outliers of Pseudomonas aeruginosa of environmental origin have recently emerged as infectious for humans. Here we present the first genome-wide analysis of an isolate that caused fatal hemorrhagic pneumonia. We demonstrate that, in two sequential clones, CLJ1 and CLJ3, recovered from a patient with chronic pulmonary disease, insertion of a mobile genetic element into the P. aeruginosa chromosome affected major virulence-associated phenotypes and led to increased resistance to antibiotics used to treat the patient. Comparative proteome and transcriptome analyses revealed that this insertion sequence, ISL3, disrupted genes encoding flagellar components, type IV pili, O-specific antigens, translesion polymerase and enzymes producing hydrogen cyanide. CLJ3 possessed seven fold more IS insertions than CLJ1, some modifying its susceptibility to antibiotics by disrupting the genes for the outer-membrane porin OprD and the regulator of β-lactamase expression AmpD. In the Galleria mellonella larvae model, the two strains displayed different levels of virulence, with CLJ1 being highly pathogenic. This work reveals ISs as major players in enhancing the pathogenic potential of a P. aeruginosa taxonomic outlier by modulating both, the virulence and the resistance to antimicrobials, and explains the ability of this bacterium to adapt from the environment to a human host." @default.
- W2896340470 created "2018-10-26" @default.
- W2896340470 creator A5025367066 @default.
- W2896340470 creator A5030266868 @default.
- W2896340470 creator A5034852351 @default.
- W2896340470 creator A5046675459 @default.
- W2896340470 creator A5051783756 @default.
- W2896340470 creator A5053422448 @default.
- W2896340470 creator A5081440902 @default.
- W2896340470 creator A5085304931 @default.
- W2896340470 creator A5089107985 @default.
- W2896340470 date "2018-10-25" @default.
- W2896340470 modified "2023-10-18" @default.
- W2896340470 title "Insertion sequences drive the emergence of a highly adapted human pathogen" @default.
- W2896340470 cites W1480808855 @default.
- W2896340470 cites W1491637723 @default.
- W2896340470 cites W1524016979 @default.
- W2896340470 cites W1557130453 @default.
- W2896340470 cites W1747728550 @default.
- W2896340470 cites W1922669508 @default.
- W2896340470 cites W1970517964 @default.
- W2896340470 cites W1977198161 @default.
- W2896340470 cites W1979152503 @default.
- W2896340470 cites W1985687704 @default.
- W2896340470 cites W1985886752 @default.
- W2896340470 cites W1990710729 @default.
- W2896340470 cites W1991330646 @default.
- W2896340470 cites W1992153554 @default.
- W2896340470 cites W1999979510 @default.
- W2896340470 cites W2004548026 @default.
- W2896340470 cites W2007153665 @default.
- W2896340470 cites W2008856488 @default.
- W2896340470 cites W2010559454 @default.
- W2896340470 cites W2024769389 @default.
- W2896340470 cites W2035226835 @default.
- W2896340470 cites W2036335453 @default.
- W2896340470 cites W2046861479 @default.
- W2896340470 cites W2051064805 @default.
- W2896340470 cites W2056206966 @default.
- W2896340470 cites W2058670635 @default.
- W2896340470 cites W2066480710 @default.
- W2896340470 cites W2067906280 @default.
- W2896340470 cites W2073905603 @default.
- W2896340470 cites W2077572900 @default.
- W2896340470 cites W2080752012 @default.
- W2896340470 cites W2085966004 @default.
- W2896340470 cites W2086358238 @default.
- W2896340470 cites W2092631613 @default.
- W2896340470 cites W2096163314 @default.
- W2896340470 cites W2096383266 @default.
- W2896340470 cites W2103132055 @default.
- W2896340470 cites W2110104778 @default.
- W2896340470 cites W2113720993 @default.
- W2896340470 cites W2124365246 @default.
- W2896340470 cites W2127036970 @default.
- W2896340470 cites W2127435093 @default.
- W2896340470 cites W2129569545 @default.
- W2896340470 cites W2130951311 @default.
- W2896340470 cites W2133740160 @default.
- W2896340470 cites W2135581618 @default.
- W2896340470 cites W2135623402 @default.
- W2896340470 cites W2135668587 @default.
- W2896340470 cites W2137160824 @default.
- W2896340470 cites W2139411571 @default.
- W2896340470 cites W2141874107 @default.
- W2896340470 cites W2145500507 @default.
- W2896340470 cites W2146331405 @default.
- W2896340470 cites W2148054572 @default.
- W2896340470 cites W2149452073 @default.
- W2896340470 cites W2156328657 @default.
- W2896340470 cites W2157249364 @default.
- W2896340470 cites W2157996877 @default.
- W2896340470 cites W2158714788 @default.
- W2896340470 cites W2158804744 @default.
- W2896340470 cites W2160263627 @default.
- W2896340470 cites W2162792752 @default.
- W2896340470 cites W2163034686 @default.
- W2896340470 cites W2165913026 @default.
- W2896340470 cites W2179324586 @default.
- W2896340470 cites W2179438025 @default.
- W2896340470 cites W2210708493 @default.
- W2896340470 cites W2216081663 @default.
- W2896340470 cites W2232017074 @default.
- W2896340470 cites W2265903773 @default.
- W2896340470 cites W2281337223 @default.
- W2896340470 cites W2308848325 @default.
- W2896340470 cites W2328867419 @default.
- W2896340470 cites W2467926052 @default.
- W2896340470 cites W2500115389 @default.
- W2896340470 cites W2508652771 @default.
- W2896340470 cites W2530836702 @default.
- W2896340470 cites W2533105729 @default.
- W2896340470 cites W2535087456 @default.
- W2896340470 cites W2559191318 @default.
- W2896340470 cites W2563041054 @default.
- W2896340470 cites W2582027265 @default.
- W2896340470 cites W2582033886 @default.
- W2896340470 cites W2595931588 @default.
- W2896340470 cites W2607373980 @default.
- W2896340470 cites W2611183201 @default.