FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896342012> ?p ?o ?g. }

• W2896342012 endingPage "400" @default.
• W2896342012 startingPage "392" @default.
• W2896342012 abstract "Abstract Aim In the present study quercetin was studied for its role in inflammation, oxidative stress markers and 5-HT levels in unpredictable chronic mild stress (UCMS) animal model of depression. Materials and Methods The mice were randomized into different groups trained for UCMS protocol followed by different drug treatments. Treatments were started after 2 weeks from the start of UCMS protocol and continued up to 6 weeks. The behavioral tests such as modified forced swimming (MFST), tail suspension (TST) and open field tests were performed on week 6, at least 24 h after the last drug treatment. Behavioral tests were preceded following animal sacrifice for biochemical estimations. Results A significant decrease in swimming, climbing times and increase in immobility time in MFST and TST was observed in UCMS group. Administration of quercetin (25 mg/kg per orally (p.o) reversed these times in MFST and TST. A decrease in no. of field crossing, time spent in centre and no. of rearing were observed in UCMS group. Quercetin reduced these observations in open field test. There was a decrease in superoxide dismutase (SOD), glutathione (GSH), catalase and 5 HT levels in the brain tissue. Quercetin treatment significantly augmented SOD, GSH, catalase and 5 HT levels. Glutamate, TNF-α and IL-6 levels were increased in UCMS group while quercetin decreased these cytokines. Conclusion Quercetin resulted antidepressant-like effect by its antioxidant, anti-inflammatory activities, reduced excitotoxicity and augmented 5 HT levels. This pointed out the usefulness of this phenolic compound as adjuvent drug along with other antidepressant drugs." @default.
• W2896342012 created "2018-10-26" @default.
• W2896342012 creator A5023024286 @default.
• W2896342012 creator A5027630088 @default.
• W2896342012 creator A5081703247 @default.
• W2896342012 date "2018-10-08" @default.
• W2896342012 modified "2023-10-16" @default.
• W2896342012 title "A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice" @default.
• W2896342012 cites W10052869 @default.
• W2896342012 cites W118881033 @default.
• W2896342012 cites W1516644432 @default.
• W2896342012 cites W1539142828 @default.
• W2896342012 cites W1775749144 @default.
• W2896342012 cites W1963928446 @default.
• W2896342012 cites W1966037459 @default.
• W2896342012 cites W1973808376 @default.
• W2896342012 cites W1981184057 @default.
• W2896342012 cites W1985503795 @default.
• W2896342012 cites W1987798935 @default.
• W2896342012 cites W1990547035 @default.
• W2896342012 cites W1990784490 @default.
• W2896342012 cites W2000118672 @default.
• W2896342012 cites W2001273234 @default.
• W2896342012 cites W2004778903 @default.
• W2896342012 cites W2006370393 @default.
• W2896342012 cites W2007374519 @default.
• W2896342012 cites W2009288654 @default.
• W2896342012 cites W2009329132 @default.
• W2896342012 cites W2009455370 @default.
• W2896342012 cites W2025972014 @default.
• W2896342012 cites W2027291501 @default.
• W2896342012 cites W2028579187 @default.
• W2896342012 cites W2033214026 @default.
• W2896342012 cites W2037909938 @default.
• W2896342012 cites W2041815385 @default.
• W2896342012 cites W2042085844 @default.
• W2896342012 cites W2058537330 @default.
• W2896342012 cites W2059416963 @default.
• W2896342012 cites W2061248667 @default.
• W2896342012 cites W2063576996 @default.
• W2896342012 cites W2064965507 @default.
• W2896342012 cites W2072869405 @default.
• W2896342012 cites W2081494794 @default.
• W2896342012 cites W2086554774 @default.
• W2896342012 cites W2088866343 @default.
• W2896342012 cites W2091652677 @default.
• W2896342012 cites W2096548382 @default.
• W2896342012 cites W2097740790 @default.
• W2896342012 cites W2107337543 @default.
• W2896342012 cites W2109223810 @default.
• W2896342012 cites W2109694255 @default.
• W2896342012 cites W2118659222 @default.
• W2896342012 cites W2126795224 @default.
• W2896342012 cites W2126967233 @default.
• W2896342012 cites W2150943659 @default.
• W2896342012 cites W2167314970 @default.
• W2896342012 cites W23376145 @default.
• W2896342012 cites W2390123160 @default.
• W2896342012 doi "https://doi.org/10.1055/a-0748-5518" @default.
• W2896342012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296804" @default.
• W2896342012 hasPublicationYear "2018" @default.
• W2896342012 type Work @default.
• W2896342012 sameAs 2896342012 @default.
• W2896342012 citedByCount "32" @default.
• W2896342012 countsByYear W28963420122020 @default.
• W2896342012 countsByYear W28963420122021 @default.
• W2896342012 countsByYear W28963420122022 @default.
• W2896342012 countsByYear W28963420122023 @default.
• W2896342012 crossrefType "journal-article" @default.
• W2896342012 hasAuthorship W2896342012A5023024286 @default.
• W2896342012 hasAuthorship W2896342012A5027630088 @default.
• W2896342012 hasAuthorship W2896342012A5081703247 @default.
• W2896342012 hasConcept C126322002 @default.
• W2896342012 hasConcept C136569192 @default.
• W2896342012 hasConcept C181199279 @default.
• W2896342012 hasConcept C185592680 @default.
• W2896342012 hasConcept C2775838275 @default.
• W2896342012 hasConcept C2776151105 @default.
• W2896342012 hasConcept C2778004101 @default.
• W2896342012 hasConcept C2778979269 @default.
• W2896342012 hasConcept C2779085643 @default.
• W2896342012 hasConcept C2779177272 @default.
• W2896342012 hasConcept C2781001258 @default.
• W2896342012 hasConcept C2781161787 @default.
• W2896342012 hasConcept C2781263971 @default.
• W2896342012 hasConcept C538909803 @default.
• W2896342012 hasConcept C55493867 @default.
• W2896342012 hasConcept C71924100 @default.
• W2896342012 hasConcept C98274493 @default.
• W2896342012 hasConceptScore W2896342012C126322002 @default.
• W2896342012 hasConceptScore W2896342012C136569192 @default.
• W2896342012 hasConceptScore W2896342012C181199279 @default.
• W2896342012 hasConceptScore W2896342012C185592680 @default.
• W2896342012 hasConceptScore W2896342012C2775838275 @default.
• W2896342012 hasConceptScore W2896342012C2776151105 @default.
• W2896342012 hasConceptScore W2896342012C2778004101 @default.
• W2896342012 hasConceptScore W2896342012C2778979269 @default.
• W2896342012 hasConceptScore W2896342012C2779085643 @default.

• next