Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896363900> ?p ?o ?g. }
- W2896363900 abstract "Abstract Cold-inducible RNA binding protein (CIRBP) has been reported to be associated with distinct tumorigenesis. In this study, we investigated the role of CIRBP in human bladder cancer (BCa), indicating that CIRBP is overexpressed in BCa tissues and cell lines to promote proliferation and migration. Moreover, CIRBP could induce expression of HIF-1α via binding to the 3′-UTR of its mRNA to increase the mRNA stability in BCa cells. Furthermore, we demonstrated that PTGIS is a HIF-1α targeted gene, a major regulator in hypoxic cancer progression by activating transcription of various oncogenes. Our results also suggested that overexpression of HIF-1α may suppress the expression of PTGIS in BCa cells, by binding to HRE sequence at the promoter region of PTGIS. In addition, we found a strongly downregulation of PTGIS in BCa tissue and transcriptionally inhibited by HIF-1α in BCa cells, which could be triggered by its DNA methylation. Further result suggested that knockdown of CIRBP could promote the expression of PTGIS, meanwhile knockdown of PTGIS could partially rescue CIRBP-deficiency induced inhibition of migration and proliferation in BCa cells. Taken together, our study indicated that CIRBP could be a novel oncogene in human bladder cancer inducing transcription of HIF-1α, which could inhibit expression of methylated PTGIS." @default.
- W2896363900 created "2018-10-26" @default.
- W2896363900 creator A5008786340 @default.
- W2896363900 creator A5009012652 @default.
- W2896363900 creator A5015211419 @default.
- W2896363900 creator A5025285167 @default.
- W2896363900 creator A5030921116 @default.
- W2896363900 creator A5045740849 @default.
- W2896363900 creator A5051862250 @default.
- W2896363900 creator A5063968535 @default.
- W2896363900 creator A5066028215 @default.
- W2896363900 creator A5076763144 @default.
- W2896363900 date "2018-10-12" @default.
- W2896363900 modified "2023-10-16" @default.
- W2896363900 title "CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1α" @default.
- W2896363900 cites W1557548215 @default.
- W2896363900 cites W1757407923 @default.
- W2896363900 cites W1918281504 @default.
- W2896363900 cites W1929849064 @default.
- W2896363900 cites W1974148528 @default.
- W2896363900 cites W1975984062 @default.
- W2896363900 cites W1979858258 @default.
- W2896363900 cites W1981487137 @default.
- W2896363900 cites W1983833034 @default.
- W2896363900 cites W1984004239 @default.
- W2896363900 cites W1995462963 @default.
- W2896363900 cites W2000122597 @default.
- W2896363900 cites W2002433286 @default.
- W2896363900 cites W2009462679 @default.
- W2896363900 cites W2014695629 @default.
- W2896363900 cites W2021185028 @default.
- W2896363900 cites W2026553408 @default.
- W2896363900 cites W2029406352 @default.
- W2896363900 cites W2035801409 @default.
- W2896363900 cites W2039500562 @default.
- W2896363900 cites W2040464123 @default.
- W2896363900 cites W2062289724 @default.
- W2896363900 cites W2071766218 @default.
- W2896363900 cites W2078672365 @default.
- W2896363900 cites W2079015277 @default.
- W2896363900 cites W2085650758 @default.
- W2896363900 cites W2086818383 @default.
- W2896363900 cites W2089692551 @default.
- W2896363900 cites W2096048497 @default.
- W2896363900 cites W2099877164 @default.
- W2896363900 cites W2100830025 @default.
- W2896363900 cites W2107248702 @default.
- W2896363900 cites W2107751591 @default.
- W2896363900 cites W2109590319 @default.
- W2896363900 cites W2114597279 @default.
- W2896363900 cites W2118655588 @default.
- W2896363900 cites W2122569219 @default.
- W2896363900 cites W2124111730 @default.
- W2896363900 cites W2125388997 @default.
- W2896363900 cites W2130219349 @default.
- W2896363900 cites W2130391651 @default.
- W2896363900 cites W2137465719 @default.
- W2896363900 cites W2150699859 @default.
- W2896363900 cites W2160975452 @default.
- W2896363900 cites W2163069245 @default.
- W2896363900 cites W2164451932 @default.
- W2896363900 cites W2281720105 @default.
- W2896363900 cites W2292406697 @default.
- W2896363900 cites W2327922861 @default.
- W2896363900 cites W2414831439 @default.
- W2896363900 cites W2467960635 @default.
- W2896363900 cites W2478743214 @default.
- W2896363900 cites W2534069516 @default.
- W2896363900 cites W2554722767 @default.
- W2896363900 cites W2790354504 @default.
- W2896363900 cites W4211053712 @default.
- W2896363900 cites W4285719527 @default.
- W2896363900 cites W4362223593 @default.
- W2896363900 cites W628038580 @default.
- W2896363900 doi "https://doi.org/10.1038/s41419-018-1109-5" @default.
- W2896363900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185914" @default.
- W2896363900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315244" @default.
- W2896363900 hasPublicationYear "2018" @default.
- W2896363900 type Work @default.
- W2896363900 sameAs 2896363900 @default.
- W2896363900 citedByCount "36" @default.
- W2896363900 countsByYear W28963639002019 @default.
- W2896363900 countsByYear W28963639002020 @default.
- W2896363900 countsByYear W28963639002021 @default.
- W2896363900 countsByYear W28963639002022 @default.
- W2896363900 countsByYear W28963639002023 @default.
- W2896363900 crossrefType "journal-article" @default.
- W2896363900 hasAuthorship W2896363900A5008786340 @default.
- W2896363900 hasAuthorship W2896363900A5009012652 @default.
- W2896363900 hasAuthorship W2896363900A5015211419 @default.
- W2896363900 hasAuthorship W2896363900A5025285167 @default.
- W2896363900 hasAuthorship W2896363900A5030921116 @default.
- W2896363900 hasAuthorship W2896363900A5045740849 @default.
- W2896363900 hasAuthorship W2896363900A5051862250 @default.
- W2896363900 hasAuthorship W2896363900A5063968535 @default.
- W2896363900 hasAuthorship W2896363900A5066028215 @default.
- W2896363900 hasAuthorship W2896363900A5076763144 @default.
- W2896363900 hasBestOaLocation W28963639001 @default.
- W2896363900 hasConcept C104317684 @default.
- W2896363900 hasConcept C127561419 @default.