FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896367237> ?p ?o ?g. }

• W2896367237 endingPage "224" @default.
• W2896367237 startingPage "218" @default.
• W2896367237 abstract "Background Up to 60% of patients who undergo curative-intent pancreatic ductal adenocarcinoma (PDAC) resection experience disease recurrence within six months. We recently published a systematic review of prognostic immunohistochemical biomarkers in PDAC and shortlisted a panel of those reported with the highest level of evidence, including p53, p16, Ca-125, S100A4, FOXC1, EGFR, mesothelin, CD24 and UPAR. This study aims to discover and validate the prognostic significance of a combinatorial panel of tumor biomarkers in patients with resected PDAC. Methods Patients who underwent PDAC resection were included from a single institution discovery cohort and a multi-institutional validation cohort. Tumors in the discovery cohort were stained immunohistochemically for all nine shortlisted biomarkers. Biomarkers significantly associated with overall survival (OS) were reevaluated as a combinatorial panel in both discovery and validation cohorts for its prognostic significance. Results 224 and 191 patients were included in the discovery and validation cohorts, respectively. In both cohorts, S100A4, Ca-125 and mesothelin expression were associated with shorter OS. In both cohorts, the number of these biomarkers expressed was significantly associated with OS (discovery cohort 36.8 vs. 26.4 vs 16.3 vs 12.8 months, P < 0.001; validation cohort 25.2 vs 18.3 vs 13.6 vs 11.9 months, P = 0.008 for expression of zero, one, two and three biomarkers, respectively). On multivariable analysis, expression of at least one of three biomarkers was independently associated with shorter OS. Conclusion Combinations of S100A4, Ca-125 and mesothelin expression stratify survival after resection of localized PDAC. Co-expression of all three biomarkers is associated with the poorest prognostic outcome." @default.
• W2896367237 created "2018-10-26" @default.
• W2896367237 creator A5000949291 @default.
• W2896367237 creator A5014740620 @default.
• W2896367237 creator A5018860994 @default.
• W2896367237 creator A5019289107 @default.
• W2896367237 creator A5032567530 @default.
• W2896367237 creator A5037493005 @default.
• W2896367237 creator A5038289205 @default.
• W2896367237 creator A5050427893 @default.
• W2896367237 creator A5056675811 @default.
• W2896367237 creator A5063111253 @default.
• W2896367237 creator A5083821463 @default.
• W2896367237 creator A5085372050 @default.
• W2896367237 creator A5086008434 @default.
• W2896367237 creator A5086859802 @default.
• W2896367237 date "2019-02-01" @default.
• W2896367237 modified "2023-10-16" @default.
• W2896367237 title "Biomarker panel predicts survival after resection in pancreatic ductal adenocarcinoma: A multi-institutional cohort study" @default.
• W2896367237 cites W1966186465 @default.
• W2896367237 cites W1968812902 @default.
• W2896367237 cites W1970383271 @default.
• W2896367237 cites W1987313243 @default.
• W2896367237 cites W2019214567 @default.
• W2896367237 cites W2030235885 @default.
• W2896367237 cites W2033961695 @default.
• W2896367237 cites W2082059231 @default.
• W2896367237 cites W2129197203 @default.
• W2896367237 cites W2151021631 @default.
• W2896367237 cites W2154790710 @default.
• W2896367237 cites W2285093314 @default.
• W2896367237 cites W2301892066 @default.
• W2896367237 cites W2317459595 @default.
• W2896367237 cites W2471893819 @default.
• W2896367237 cites W2518780709 @default.
• W2896367237 cites W2595525832 @default.
• W2896367237 cites W2604341448 @default.
• W2896367237 cites W2728246113 @default.
• W2896367237 cites W2799575632 @default.
• W2896367237 doi "https://doi.org/10.1016/j.ejso.2018.10.050" @default.
• W2896367237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30348604" @default.
• W2896367237 hasPublicationYear "2019" @default.
• W2896367237 type Work @default.
• W2896367237 sameAs 2896367237 @default.
• W2896367237 citedByCount "21" @default.
• W2896367237 countsByYear W28963672372020 @default.
• W2896367237 countsByYear W28963672372021 @default.
• W2896367237 countsByYear W28963672372022 @default.
• W2896367237 countsByYear W28963672372023 @default.
• W2896367237 crossrefType "journal-article" @default.
• W2896367237 hasAuthorship W2896367237A5000949291 @default.
• W2896367237 hasAuthorship W2896367237A5014740620 @default.
• W2896367237 hasAuthorship W2896367237A5018860994 @default.
• W2896367237 hasAuthorship W2896367237A5019289107 @default.
• W2896367237 hasAuthorship W2896367237A5032567530 @default.
• W2896367237 hasAuthorship W2896367237A5037493005 @default.
• W2896367237 hasAuthorship W2896367237A5038289205 @default.
• W2896367237 hasAuthorship W2896367237A5050427893 @default.
• W2896367237 hasAuthorship W2896367237A5056675811 @default.
• W2896367237 hasAuthorship W2896367237A5063111253 @default.
• W2896367237 hasAuthorship W2896367237A5083821463 @default.
• W2896367237 hasAuthorship W2896367237A5085372050 @default.
• W2896367237 hasAuthorship W2896367237A5086008434 @default.
• W2896367237 hasAuthorship W2896367237A5086859802 @default.
• W2896367237 hasBestOaLocation W28963672372 @default.
• W2896367237 hasConcept C121608353 @default.
• W2896367237 hasConcept C126322002 @default.
• W2896367237 hasConcept C142724271 @default.
• W2896367237 hasConcept C143998085 @default.
• W2896367237 hasConcept C204232928 @default.
• W2896367237 hasConcept C2777045440 @default.
• W2896367237 hasConcept C2780210213 @default.
• W2896367237 hasConcept C2781197716 @default.
• W2896367237 hasConcept C2992026798 @default.
• W2896367237 hasConcept C55493867 @default.
• W2896367237 hasConcept C71924100 @default.
• W2896367237 hasConcept C72563966 @default.
• W2896367237 hasConcept C86803240 @default.
• W2896367237 hasConceptScore W2896367237C121608353 @default.
• W2896367237 hasConceptScore W2896367237C126322002 @default.
• W2896367237 hasConceptScore W2896367237C142724271 @default.
• W2896367237 hasConceptScore W2896367237C143998085 @default.
• W2896367237 hasConceptScore W2896367237C204232928 @default.
• W2896367237 hasConceptScore W2896367237C2777045440 @default.
• W2896367237 hasConceptScore W2896367237C2780210213 @default.
• W2896367237 hasConceptScore W2896367237C2781197716 @default.
• W2896367237 hasConceptScore W2896367237C2992026798 @default.
• W2896367237 hasConceptScore W2896367237C55493867 @default.
• W2896367237 hasConceptScore W2896367237C71924100 @default.
• W2896367237 hasConceptScore W2896367237C72563966 @default.
• W2896367237 hasConceptScore W2896367237C86803240 @default.
• W2896367237 hasIssue "2" @default.
• W2896367237 hasLocation W28963672371 @default.
• W2896367237 hasLocation W28963672372 @default.
• W2896367237 hasLocation W28963672373 @default.
• W2896367237 hasOpenAccess W2896367237 @default.
• W2896367237 hasPrimaryLocation W28963672371 @default.
• W2896367237 hasRelatedWork W1996558981 @default.

• next