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- W2896374535 abstract "Re-engineering mammalian cell surfaces enables modulation of their phenotype, function, and interactions with external markers and may find application in cell-based therapies. Here we use metabolic glycan labeling to install azido groups onto the cell surface, which can act as anchor points to enable rapid, simple, and robust “click” functionalization by the addition of a polymer bearing orthogonally reactive functionality. Using this strategy, new cell surface functionality was introduced by using telechelic polymers with fluorescence or biotin termini, demonstrating that recruitment of biomacromolecules is possible. This approach may enable the attachment of payloads and modulation of cell function and fate, as well as providing a tool to interface synthetic polymers with biological systems." @default.
- W2896374535 created "2018-10-26" @default.
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- W2896374535 date "2018-10-10" @default.
- W2896374535 modified "2023-10-14" @default.
- W2896374535 title "Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans" @default.
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- W2896374535 doi "https://doi.org/10.1021/acsmacrolett.8b00675" @default.
- W2896374535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6281312" @default.
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- W2896374535 hasPublicationYear "2018" @default.
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