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• W2896410904 abstract "Lower respiratory tract infections and tuberculosis are responsible for the death of about 4.5 million people each year and are the main causes of mortality in children under 5 years of age. Streptococcus pneumoniae is the most common bacterial pathogen associated with severe pneumonia, although other Gram-positive and Gram-negative bacteria are involved in respiratory infections as well. The ability of these pathogens to persist and produce infection under the appropriate conditions is also associated with their capacity to form biofilms in the respiratory mucous membranes. Adding to the difficulty of treating biofilm-forming bacteria with antibiotics, many of these strains are becoming multidrug resistant, and thus the alternative therapeutics available for combating this kind of infections are rapidly depleting. Given these concerns, it is urgent to consider other unconventional strategies and, in this regard, phage lysins represent an attractive resource to circumvent some of the current issues in infection treatment. When added exogenously, lysins break specific bonds of the peptidoglycan and have potent bactericidal effects against susceptible bacteria. These enzymes possess interesting features, including that they do not trigger an adverse immune response and raise of resistance is very unlikely. Although Gram-negative bacteria had been considered refractory to these compounds, strategies to overcome this drawback have been developed recently. In this review we describe the most relevant in vitro and in vivo results obtained to date with lysins against bacterial respiratory pathogens." @default.
• W2896410904 created "2018-10-26" @default.
• W2896410904 creator A5039966065 @default.
• W2896410904 creator A5060687832 @default.
• W2896410904 creator A5067225279 @default.
• W2896410904 date "2018-10-16" @default.
• W2896410904 modified "2023-10-14" @default.
• W2896410904 title "Phage Lysins for Fighting Bacterial Respiratory Infections: A New Generation of Antimicrobials" @default.
• W2896410904 cites W1522043729 @default.
• W2896410904 cites W1554712188 @default.
• W2896410904 cites W1559607065 @default.
• W2896410904 cites W1965242138 @default.
• W2896410904 cites W1966313166 @default.
• W2896410904 cites W1969788984 @default.
• W2896410904 cites W1970532969 @default.
• W2896410904 cites W1973795230 @default.
• W2896410904 cites W1976004941 @default.
• W2896410904 cites W1981232704 @default.
• W2896410904 cites W1985226473 @default.
• W2896410904 cites W1987965479 @default.
• W2896410904 cites W1993716739 @default.
• W2896410904 cites W1996168011 @default.
• W2896410904 cites W2000441147 @default.
• W2896410904 cites W2003690898 @default.
• W2896410904 cites W2004487933 @default.
• W2896410904 cites W2005214154 @default.
• W2896410904 cites W2006571639 @default.
• W2896410904 cites W2006793281 @default.
• W2896410904 cites W2009434802 @default.
• W2896410904 cites W2009846376 @default.
• W2896410904 cites W2010700705 @default.
• W2896410904 cites W2011957174 @default.
• W2896410904 cites W2012253873 @default.
• W2896410904 cites W2019024855 @default.
• W2896410904 cites W2019509159 @default.
• W2896410904 cites W2020000622 @default.
• W2896410904 cites W2023907724 @default.
• W2896410904 cites W2025919466 @default.
• W2896410904 cites W2026948425 @default.
• W2896410904 cites W2027264038 @default.
• W2896410904 cites W2029075192 @default.
• W2896410904 cites W2030458800 @default.
• W2896410904 cites W2033575336 @default.
• W2896410904 cites W2034583138 @default.
• W2896410904 cites W2035039252 @default.
• W2896410904 cites W2036437603 @default.
• W2896410904 cites W2039319063 @default.
• W2896410904 cites W2041105099 @default.
• W2896410904 cites W2043574444 @default.
• W2896410904 cites W2043669567 @default.
• W2896410904 cites W2047019892 @default.
• W2896410904 cites W2052494378 @default.
• W2896410904 cites W2054751188 @default.
• W2896410904 cites W2055823712 @default.
• W2896410904 cites W2060394844 @default.
• W2896410904 cites W2063206735 @default.
• W2896410904 cites W2064125274 @default.
• W2896410904 cites W2068805676 @default.
• W2896410904 cites W2069018460 @default.
• W2896410904 cites W2069023194 @default.
• W2896410904 cites W2071660654 @default.
• W2896410904 cites W2077728846 @default.
• W2896410904 cites W2080022673 @default.
• W2896410904 cites W2085461157 @default.
• W2896410904 cites W2090627629 @default.
• W2896410904 cites W2093130327 @default.
• W2896410904 cites W2094743418 @default.
• W2896410904 cites W2096326200 @default.
• W2896410904 cites W2098637615 @default.
• W2896410904 cites W2099628989 @default.
• W2896410904 cites W2108670255 @default.
• W2896410904 cites W2108734609 @default.
• W2896410904 cites W2109861005 @default.
• W2896410904 cites W2111927820 @default.
• W2896410904 cites W2116369083 @default.
• W2896410904 cites W2119917426 @default.
• W2896410904 cites W2121138643 @default.
• W2896410904 cites W2121457314 @default.
• W2896410904 cites W2122229232 @default.
• W2896410904 cites W2122292306 @default.
• W2896410904 cites W2123300343 @default.
• W2896410904 cites W2124023270 @default.
• W2896410904 cites W2127308325 @default.
• W2896410904 cites W2129430097 @default.
• W2896410904 cites W2133218818 @default.
• W2896410904 cites W2134282868 @default.
• W2896410904 cites W2141339781 @default.
• W2896410904 cites W2141365771 @default.
• W2896410904 cites W2141397032 @default.
• W2896410904 cites W2148632765 @default.
• W2896410904 cites W2149225426 @default.
• W2896410904 cites W2151528413 @default.
• W2896410904 cites W2151649467 @default.
• W2896410904 cites W2151680163 @default.
• W2896410904 cites W2152343141 @default.
• W2896410904 cites W2152655939 @default.
• W2896410904 cites W2154066176 @default.
• W2896410904 cites W2154938809 @default.
• W2896410904 cites W2159398380 @default.
• W2896410904 cites W2160301892 @default.

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