Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896411266> ?p ?o ?g. }
- W2896411266 abstract "Gemcitabine is a standard treatment for advanced pancreatic cancer patients but can cause chemoresistance during treatment. The chemoresistant cells have features of cancer stem cells (CSCs). Resveratrol has been reported to overcome the resistance induced by gemcitabine. However, the mechanism by which resveratrol enhances chemosensitivity remains elusive. Here, we explored the mechanism by which resveratrol enhanced chemosensitivity and the role of sterol regulatory element binding protein 1 (SREBP1) in gemcitabine-induced stemness.The pancreatic cancer cell lines MiaPaCa-2 and Panc-1 were treated under different conditions. Methyl thiazolyl tetrazolium and colony formation assays were performed to evaluate effects on proliferation. Flow cytometry was conducted to detect apoptosis. Oil red O staining was performed to examine lipid synthesis. The sphere formation assay was applied to investigate the stemness of cancer cells. Immunohistochemistry was performed on tumour tissue obtained from treated KPC mice.Resveratrol enhanced the sensitivity of gemcitabine and inhibited lipid synthesis via SREBP1. Knockdown of SREBP1 limited the sphere formation ability and suppressed the expression of CSC markers. Furthermore, suppression of SREBP1 induced by resveratrol reversed the gemcitabine-induced stemness. These results were validated in a KPC mouse model.Our data provide evidence that resveratrol reverses the stemness induced by gemcitabine by targeting SREBP1 both in vitro and in vivo. Thus, resveratrol can be an effective chemotherapy sensitizer, and SREBP1 may be a rational therapeutic target." @default.
- W2896411266 created "2018-10-26" @default.
- W2896411266 creator A5000195252 @default.
- W2896411266 creator A5005416798 @default.
- W2896411266 creator A5010762548 @default.
- W2896411266 creator A5012438384 @default.
- W2896411266 creator A5015888710 @default.
- W2896411266 creator A5024240417 @default.
- W2896411266 creator A5027770418 @default.
- W2896411266 creator A5038040398 @default.
- W2896411266 creator A5042026897 @default.
- W2896411266 creator A5051440995 @default.
- W2896411266 creator A5068252474 @default.
- W2896411266 creator A5070309078 @default.
- W2896411266 creator A5075443051 @default.
- W2896411266 creator A5087435298 @default.
- W2896411266 creator A5088613739 @default.
- W2896411266 date "2018-10-19" @default.
- W2896411266 modified "2023-10-17" @default.
- W2896411266 title "Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting <scp>SREBP</scp>1" @default.
- W2896411266 cites W1757407923 @default.
- W2896411266 cites W1989115563 @default.
- W2896411266 cites W1998158490 @default.
- W2896411266 cites W2022442325 @default.
- W2896411266 cites W2037059323 @default.
- W2896411266 cites W2049613371 @default.
- W2896411266 cites W2050536768 @default.
- W2896411266 cites W2056040807 @default.
- W2896411266 cites W2066452770 @default.
- W2896411266 cites W2096442753 @default.
- W2896411266 cites W2099853576 @default.
- W2896411266 cites W2102408764 @default.
- W2896411266 cites W2104541017 @default.
- W2896411266 cites W2115420718 @default.
- W2896411266 cites W2129185045 @default.
- W2896411266 cites W2143492469 @default.
- W2896411266 cites W2150591941 @default.
- W2896411266 cites W2154317507 @default.
- W2896411266 cites W2154989132 @default.
- W2896411266 cites W2156348098 @default.
- W2896411266 cites W2159728029 @default.
- W2896411266 cites W2164015122 @default.
- W2896411266 cites W2185435318 @default.
- W2896411266 cites W2192943385 @default.
- W2896411266 cites W2218490930 @default.
- W2896411266 cites W2258673083 @default.
- W2896411266 cites W2508385150 @default.
- W2896411266 cites W2521053415 @default.
- W2896411266 cites W2560441966 @default.
- W2896411266 cites W2567384458 @default.
- W2896411266 cites W2570618306 @default.
- W2896411266 cites W2592828140 @default.
- W2896411266 cites W2594873390 @default.
- W2896411266 cites W2596243280 @default.
- W2896411266 cites W2614546816 @default.
- W2896411266 cites W2735674418 @default.
- W2896411266 cites W2738454452 @default.
- W2896411266 cites W2747955726 @default.
- W2896411266 cites W2751815312 @default.
- W2896411266 cites W2754223784 @default.
- W2896411266 cites W2759896015 @default.
- W2896411266 cites W2767812833 @default.
- W2896411266 cites W2768095276 @default.
- W2896411266 cites W2769094265 @default.
- W2896411266 cites W2771043284 @default.
- W2896411266 cites W2773172068 @default.
- W2896411266 cites W2774981379 @default.
- W2896411266 cites W2896411266 @default.
- W2896411266 cites W4253861989 @default.
- W2896411266 doi "https://doi.org/10.1111/cpr.12514" @default.
- W2896411266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6430460" @default.
- W2896411266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30341797" @default.
- W2896411266 hasPublicationYear "2018" @default.
- W2896411266 type Work @default.
- W2896411266 sameAs 2896411266 @default.
- W2896411266 citedByCount "57" @default.
- W2896411266 countsByYear W28964112662018 @default.
- W2896411266 countsByYear W28964112662019 @default.
- W2896411266 countsByYear W28964112662020 @default.
- W2896411266 countsByYear W28964112662021 @default.
- W2896411266 countsByYear W28964112662022 @default.
- W2896411266 countsByYear W28964112662023 @default.
- W2896411266 crossrefType "journal-article" @default.
- W2896411266 hasAuthorship W2896411266A5000195252 @default.
- W2896411266 hasAuthorship W2896411266A5005416798 @default.
- W2896411266 hasAuthorship W2896411266A5010762548 @default.
- W2896411266 hasAuthorship W2896411266A5012438384 @default.
- W2896411266 hasAuthorship W2896411266A5015888710 @default.
- W2896411266 hasAuthorship W2896411266A5024240417 @default.
- W2896411266 hasAuthorship W2896411266A5027770418 @default.
- W2896411266 hasAuthorship W2896411266A5038040398 @default.
- W2896411266 hasAuthorship W2896411266A5042026897 @default.
- W2896411266 hasAuthorship W2896411266A5051440995 @default.
- W2896411266 hasAuthorship W2896411266A5068252474 @default.
- W2896411266 hasAuthorship W2896411266A5070309078 @default.
- W2896411266 hasAuthorship W2896411266A5075443051 @default.
- W2896411266 hasAuthorship W2896411266A5087435298 @default.
- W2896411266 hasAuthorship W2896411266A5088613739 @default.
- W2896411266 hasBestOaLocation W28964112661 @default.
- W2896411266 hasConcept C121608353 @default.