FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896413245> ?p ?o ?g. }

• W2896413245 abstract "The relationship between aging and epigenetic profiles has been highlighted in many recent studies. Models using somatic cell methylomes to predict age have been successfully constructed. However, gamete aging is quite distinct and as such age prediction using sperm methylomes is ineffective with current techniques. We have produced a model that utilizes human sperm DNA methylation signatures to predict chronological age by utilizing methylation array data from a total of 329 samples. The dataset used for model construction includes infertile patients, sperm donors, and individuals from the general population. Our model is capable predicting age with an R2 of 0.89, a mean absolute error (MAE) of 2.04 years, and a mean absolute percent error (MAPE) of 6.28% in our data set. We additionally investigated the reproducibility of prediction with our model in an independent cohort where 6 technical replicates of 10 individual samples were tested on different arrays. We found very similar age prediction accuracy (MAE = 2.37 years; MAPE = 7.05%) with a high degree of precision between replicates (standard deviation of only 0.877 years). Additionally, we found that smokers trended toward increased age profiles when compared to ‘never smokers’ though this pattern was only striking in a portion of the samples screened. The predictive model described herein was built to offer researchers the ability to assess “germ line age” by accessing sperm DNA methylation signatures at genomic regions affected by age. Our data suggest that this model can predict an individual’s chronological age with a high degree of accuracy regardless of fertility status and with a high degree of repeatability. Additionally, our data suggest that the aging process in sperm may be impacted by environmental factors, though this effect appears to be quite subtle and future work is needed to establish this relationship." @default.
• W2896413245 created "2018-10-26" @default.
• W2896413245 creator A5020191126 @default.
• W2896413245 creator A5057668804 @default.
• W2896413245 creator A5060287517 @default.
• W2896413245 creator A5065682481 @default.
• W2896413245 creator A5080592810 @default.
• W2896413245 date "2018-10-22" @default.
• W2896413245 modified "2023-10-13" @default.
• W2896413245 title "Paternal germ line aging: DNA methylation age prediction from human sperm" @default.
• W2896413245 cites W1412161755 @default.
• W2896413245 cites W1967224500 @default.
• W2896413245 cites W1969921074 @default.
• W2896413245 cites W1974047233 @default.
• W2896413245 cites W1979873290 @default.
• W2896413245 cites W1984822416 @default.
• W2896413245 cites W1998663807 @default.
• W2896413245 cites W2021804421 @default.
• W2896413245 cites W2023844789 @default.
• W2896413245 cites W2028839461 @default.
• W2896413245 cites W2035616108 @default.
• W2896413245 cites W2038097808 @default.
• W2896413245 cites W2053184492 @default.
• W2896413245 cites W2085745662 @default.
• W2896413245 cites W2097360283 @default.
• W2896413245 cites W2099343472 @default.
• W2896413245 cites W2100195329 @default.
• W2896413245 cites W2111604798 @default.
• W2896413245 cites W2131642527 @default.
• W2896413245 cites W2133939240 @default.
• W2896413245 cites W2153064836 @default.
• W2896413245 cites W2168623790 @default.
• W2896413245 cites W2169066906 @default.
• W2896413245 cites W2169645813 @default.
• W2896413245 cites W2229422108 @default.
• W2896413245 cites W2281913940 @default.
• W2896413245 cites W2759363180 @default.
• W2896413245 cites W2763014290 @default.
• W2896413245 cites W4294541781 @default.
• W2896413245 doi "https://doi.org/10.1186/s12864-018-5153-4" @default.
• W2896413245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6198359" @default.
• W2896413245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30348084" @default.
• W2896413245 hasPublicationYear "2018" @default.
• W2896413245 type Work @default.
• W2896413245 sameAs 2896413245 @default.
• W2896413245 citedByCount "58" @default.
• W2896413245 countsByYear W28964132452019 @default.
• W2896413245 countsByYear W28964132452020 @default.
• W2896413245 countsByYear W28964132452021 @default.
• W2896413245 countsByYear W28964132452022 @default.
• W2896413245 countsByYear W28964132452023 @default.
• W2896413245 crossrefType "journal-article" @default.
• W2896413245 hasAuthorship W2896413245A5020191126 @default.
• W2896413245 hasAuthorship W2896413245A5057668804 @default.
• W2896413245 hasAuthorship W2896413245A5060287517 @default.
• W2896413245 hasAuthorship W2896413245A5065682481 @default.
• W2896413245 hasAuthorship W2896413245A5080592810 @default.
• W2896413245 hasBestOaLocation W28964132451 @default.
• W2896413245 hasConcept C104317684 @default.
• W2896413245 hasConcept C105795698 @default.
• W2896413245 hasConcept C139945424 @default.
• W2896413245 hasConcept C150194340 @default.
• W2896413245 hasConcept C150217764 @default.
• W2896413245 hasConcept C16685009 @default.
• W2896413245 hasConcept C190727270 @default.
• W2896413245 hasConcept C2779122487 @default.
• W2896413245 hasConcept C2781087480 @default.
• W2896413245 hasConcept C2908647359 @default.
• W2896413245 hasConcept C33288867 @default.
• W2896413245 hasConcept C33923547 @default.
• W2896413245 hasConcept C41091548 @default.
• W2896413245 hasConcept C54355233 @default.
• W2896413245 hasConcept C552990157 @default.
• W2896413245 hasConcept C60644358 @default.
• W2896413245 hasConcept C70721500 @default.
• W2896413245 hasConcept C71924100 @default.
• W2896413245 hasConcept C86803240 @default.
• W2896413245 hasConcept C99454951 @default.
• W2896413245 hasConceptScore W2896413245C104317684 @default.
• W2896413245 hasConceptScore W2896413245C105795698 @default.
• W2896413245 hasConceptScore W2896413245C139945424 @default.
• W2896413245 hasConceptScore W2896413245C150194340 @default.
• W2896413245 hasConceptScore W2896413245C150217764 @default.
• W2896413245 hasConceptScore W2896413245C16685009 @default.
• W2896413245 hasConceptScore W2896413245C190727270 @default.
• W2896413245 hasConceptScore W2896413245C2779122487 @default.
• W2896413245 hasConceptScore W2896413245C2781087480 @default.
• W2896413245 hasConceptScore W2896413245C2908647359 @default.
• W2896413245 hasConceptScore W2896413245C33288867 @default.
• W2896413245 hasConceptScore W2896413245C33923547 @default.
• W2896413245 hasConceptScore W2896413245C41091548 @default.
• W2896413245 hasConceptScore W2896413245C54355233 @default.
• W2896413245 hasConceptScore W2896413245C552990157 @default.
• W2896413245 hasConceptScore W2896413245C60644358 @default.
• W2896413245 hasConceptScore W2896413245C70721500 @default.
• W2896413245 hasConceptScore W2896413245C71924100 @default.
• W2896413245 hasConceptScore W2896413245C86803240 @default.
• W2896413245 hasConceptScore W2896413245C99454951 @default.
• W2896413245 hasFunder F4320337364 @default.
• W2896413245 hasIssue "1" @default.

• next