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- W2896415526 abstract "Introduction: Cardiovascular disease (CVD) remains the common cause of morbidity and mortality in kidney transplant recipients. Cerebrovascular accident (CVA) is highly prevalent in general population. Several cardiovascular co-morbidities are conveyed in kidney transplant recipients after successful kidney transplantation but the incidence of CVA in this population is uncommon. Hypothesis: We hypothesize that renal-related risk factors for CVA occur after successful kidney transplantation. Methods: A nested case-control study from a closed cohort of advanced chronic kidney disease (CKD) or end-stage renal disease (ESRD) patients undergoing kidney transplantation between January 2006 and May 2017 was conducted. CVA is defined by brain imaging lesions consistent with localized neurological deficits. Three control patients were matched with 1 case based on age and date of kidney transplantation identified at the same time when the first episode of CVA of each case occurred (incidence density sampling method). Results: From a total of 752 kidney transplant recipients, 5 new CVA cases and 15 controls were identified during a 2-year period between September 2015 and July 2017. Mean age+/-SEM was 45.10±6.95 VS 46.57±3.02 years. In case group, 60% was male and African American; whereas, 53.33% was female and 40% was African American in the control group. Several traditional risk factors for CVD were not associated with CVA except diastolic hypertension defined as DBP <90 mmHg (OR 52, 95%CI 2.616 to 1,033.827). Compared to control group, mean DBP in cases was 17±6.31 mmHg higher (93±3.03 VS. 76±3.56, p=0.015, 95%CI -30.3083 to -3.6917). For renal-related factors, mean serum creatinine and serum phosphorus were significantly higher and mean serum albumin was significantly lower in the cases than the controls (p=0.003, <0.001, and 0.020). Conclusion: Although traditional risk factors for CVA remains after kidney transplantation, only DBP is associated with CVA and other renal-related factors including impaired renal allograft function, hyperphosphatemia, and hypoalbuminemia appears to increase the risk for CVA. Further studies are required to identify other risks and elucidate mechanistic studies of CVA in kidney transplant recipients." @default.
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- W2896415526 date "2018-01-22" @default.
- W2896415526 modified "2023-09-27" @default.
- W2896415526 title "Abstract WP115: Risk Factors for Stroke After Kidney Transplantation" @default.
- W2896415526 doi "https://doi.org/10.1161/str.49.suppl_1.wp115" @default.
- W2896415526 hasPublicationYear "2018" @default.
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