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- W2896422439 abstract "Language and other cognitive changes are common in patients with both progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), although these symptoms are often overshadowed by the more prominent motor symptoms. The differential diagnosis of these two disorders can be challenging in the early stages when motor symptoms are mild or nonspecific. Because language impairment is increasingly proving to be an early symptom in many patients with CBS and PSP, detailed language assessment may have significant utility in their differential diagnosis. Here, we use the newly developed Mini Linguistic State Examination (MLSE), a brief, yet comprehensive language assessment tool, to characterise language impairment in such cases. Thirty patients with diagnoses of probable PSP or CBS completed a pilot version of the MLSE, subtests of the Boston Diagnostic Aphasia Examination and the Addenbrooke's Cognitive Examination-III. Performance of each of the two groups was compared to the other as well as with healthy volunteers, and patients with primary progressive aphasia (PPA). Patients with PSP and CBS showed impairments in naming, repetition, reading, and comprehension that were mild compared to patients with PPA. In contrast to overall scores—which are often the only results available from published studies—analysis of the types of errors produced on the different subtasks appears most promising in distinguishing these two groups. Detailed language assessment may assist in the differential diagnosis of PSP and CBS. Types of errors are particularly informative and should be reported when assessing language in these groups." @default.
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- W2896422439 date "2018-07-01" @default.
- W2896422439 modified "2023-10-16" @default.
- W2896422439 title "P3‐471: LANGUAGE IMPAIRMENT IN PROGRESSIVE SUPRANUCLEAR PALSY AND CORTICOBASAL SYNDROME" @default.
- W2896422439 doi "https://doi.org/10.1016/j.jalz.2018.06.1835" @default.
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