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• W2896427019 abstract "A series of simplified berberine analogs was designed, synthesized, and evaluated for anti-inflammatory activity. SAR studies identified N-benzyltetrahydroisoquinoline 7d as a potent berberine analog. 7d suppressed LPS-induced inflammatory cytokine levels in both BV2 cells and primary microglia. Taken together, our results suggest that simplified BB analogs have therapeutic potential as a novel class of anti-neuroinflammatory agents." @default.
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• W2896427019 date "2018-11-01" @default.
• W2896427019 modified "2023-10-16" @default.
• W2896427019 title "Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents" @default.
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• W2896427019 doi "https://doi.org/10.1016/j.bmc.2018.10.020" @default.
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