Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896433468> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2896433468 endingPage "408" @default.
- W2896433468 startingPage "398" @default.
- W2896433468 abstract "Abstract Twenty‐four pure fragrance ingredients of concern as potential skin sensitizers were previously subjected to degradation studies and evaluated using the high throughput with dansyl cysteamine (HTS‐DCYA) method. The experimental results showed that two‐thirds of the 24 fragrance ingredients underwent chemical degradation. In some cases, such degradation was accompanied by an increase in thio‐reactivity. These results prompted us to investigate the reactivity of the same ingredients using the direct peptide reactivity assay (DPRA). In the present work, the 24 chemicals were subjected to forced degradation for 150 days, and evaluated with both DPRA and HTS‐DCYA methods. At the end of the study, four and eight compounds remained non‐reactive in the DPRA and DCYA assay, respectively. Coumarin, benzyl salicylate, benzyl cinnamate and hexyl cinnamal were found unreactive in both assays, while cinnamal, cinnamyl alcohol, hydroxycitronellal and lilial were found negative in the DCYA but positive in the DPRA method. The incongruity in reactivity of these four compounds was attributed to a possible role of pro‐oxidants formed upon degradation, resulting in depletion of peptide without formation of apparent covalent adducts with the test chemical. To validate this hypothesis, the effect of hydrogen peroxide as model pro‐oxidant on both lysine‐ and cysteine‐heptapeptide depletion in the DPRA method was thus investigated. The obtained results showed little effect of oxidative conditions on lysine depletion, while cysteine depletion was significantly affected by concentrations above 1.1 mg/L of hydrogen peroxide. Overall, both in chemico methods confirmed chemical instability should be considered when assessing the skin sensitization potential of (un)known chemicals with alternative methods." @default.
- W2896433468 created "2018-10-26" @default.
- W2896433468 creator A5022837135 @default.
- W2896433468 creator A5026678057 @default.
- W2896433468 creator A5037843364 @default.
- W2896433468 creator A5046643126 @default.
- W2896433468 creator A5059688755 @default.
- W2896433468 date "2018-10-16" @default.
- W2896433468 modified "2023-10-14" @default.
- W2896433468 title "In chemico assessment of potential sensitizers: Stability and direct peptide reactivity of 24 fragrance ingredients" @default.
- W2896433468 cites W1541066427 @default.
- W2896433468 cites W1565539247 @default.
- W2896433468 cites W1589472332 @default.
- W2896433468 cites W1718770430 @default.
- W2896433468 cites W1941198341 @default.
- W2896433468 cites W1966327639 @default.
- W2896433468 cites W1977392400 @default.
- W2896433468 cites W1996400886 @default.
- W2896433468 cites W1999209207 @default.
- W2896433468 cites W2008262313 @default.
- W2896433468 cites W2027565722 @default.
- W2896433468 cites W2030001291 @default.
- W2896433468 cites W2035639846 @default.
- W2896433468 cites W2059252070 @default.
- W2896433468 cites W2064517908 @default.
- W2896433468 cites W2088221167 @default.
- W2896433468 cites W2095712871 @default.
- W2896433468 cites W2110358899 @default.
- W2896433468 cites W2401513244 @default.
- W2896433468 cites W2412019797 @default.
- W2896433468 cites W2414397060 @default.
- W2896433468 cites W2619383248 @default.
- W2896433468 cites W2754501738 @default.
- W2896433468 doi "https://doi.org/10.1002/jat.3732" @default.
- W2896433468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30325045" @default.
- W2896433468 hasPublicationYear "2018" @default.
- W2896433468 type Work @default.
- W2896433468 sameAs 2896433468 @default.
- W2896433468 citedByCount "6" @default.
- W2896433468 countsByYear W28964334682020 @default.
- W2896433468 countsByYear W28964334682021 @default.
- W2896433468 countsByYear W28964334682022 @default.
- W2896433468 countsByYear W28964334682023 @default.
- W2896433468 crossrefType "journal-article" @default.
- W2896433468 hasAuthorship W2896433468A5022837135 @default.
- W2896433468 hasAuthorship W2896433468A5026678057 @default.
- W2896433468 hasAuthorship W2896433468A5037843364 @default.
- W2896433468 hasAuthorship W2896433468A5046643126 @default.
- W2896433468 hasAuthorship W2896433468A5059688755 @default.
- W2896433468 hasConcept C142724271 @default.
- W2896433468 hasConcept C178790620 @default.
- W2896433468 hasConcept C181199279 @default.
- W2896433468 hasConcept C185592680 @default.
- W2896433468 hasConcept C204787440 @default.
- W2896433468 hasConcept C2776016237 @default.
- W2896433468 hasConcept C2776910235 @default.
- W2896433468 hasConcept C2779201268 @default.
- W2896433468 hasConcept C2779281246 @default.
- W2896433468 hasConcept C35378473 @default.
- W2896433468 hasConcept C515207424 @default.
- W2896433468 hasConcept C533411734 @default.
- W2896433468 hasConcept C55493867 @default.
- W2896433468 hasConcept C71924100 @default.
- W2896433468 hasConceptScore W2896433468C142724271 @default.
- W2896433468 hasConceptScore W2896433468C178790620 @default.
- W2896433468 hasConceptScore W2896433468C181199279 @default.
- W2896433468 hasConceptScore W2896433468C185592680 @default.
- W2896433468 hasConceptScore W2896433468C204787440 @default.
- W2896433468 hasConceptScore W2896433468C2776016237 @default.
- W2896433468 hasConceptScore W2896433468C2776910235 @default.
- W2896433468 hasConceptScore W2896433468C2779201268 @default.
- W2896433468 hasConceptScore W2896433468C2779281246 @default.
- W2896433468 hasConceptScore W2896433468C35378473 @default.
- W2896433468 hasConceptScore W2896433468C515207424 @default.
- W2896433468 hasConceptScore W2896433468C533411734 @default.
- W2896433468 hasConceptScore W2896433468C55493867 @default.
- W2896433468 hasConceptScore W2896433468C71924100 @default.
- W2896433468 hasFunder F4320332163 @default.
- W2896433468 hasIssue "2" @default.
- W2896433468 hasLocation W28964334681 @default.
- W2896433468 hasLocation W28964334682 @default.
- W2896433468 hasOpenAccess W2896433468 @default.
- W2896433468 hasPrimaryLocation W28964334681 @default.
- W2896433468 hasRelatedWork W1994137655 @default.
- W2896433468 hasRelatedWork W2024714563 @default.
- W2896433468 hasRelatedWork W2078443639 @default.
- W2896433468 hasRelatedWork W2093382172 @default.
- W2896433468 hasRelatedWork W2136736276 @default.
- W2896433468 hasRelatedWork W2185028702 @default.
- W2896433468 hasRelatedWork W2952658248 @default.
- W2896433468 hasRelatedWork W3033962482 @default.
- W2896433468 hasRelatedWork W4225817502 @default.
- W2896433468 hasRelatedWork W4253838346 @default.
- W2896433468 hasVolume "39" @default.
- W2896433468 isParatext "false" @default.
- W2896433468 isRetracted "false" @default.
- W2896433468 magId "2896433468" @default.
- W2896433468 workType "article" @default.