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• W2896433735 abstract "Objective: To understand patient and caregiver experience with the management of neurogenic orthostatic hypotension (nOH) Background: nOH is a sustained reduction in blood pressure (BP) with postural change associated with autonomic dysfunction. Clinical symptoms include falls, leading to activity limits and diminished sense of well-being. Design/Methods: A US-based survey designed by the authors was conducted by Harris Poll. Eligible participants had Parkinson disease (PD), multiple system atrophy, or pure autonomic failure and ≥1 of the following: orthostatic hypotension (OH), nOH, low BP, OH/nOH symptoms or were caregivers of eligible patients. Descriptive statistics are reported. Results: A total of 363 patients and 128 caregivers participated in the survey. PD was the most frequent underlying diagnosis (patients: 90%, caregivers: 88%). Healthcare provider (HCP) communication with patients was rated as satisfactory by ≥75% of respondents, yet when nOH symptoms were first discussed with HCPs, only 35% of patients and 31% of caregivers reported patients received symptom management guidance. The most frequently recommended interventions by HCPs were to avoid quick positional changes (patients: 49%, caregivers: 48%), increase fluid intake (patients: 47%, caregivers: 52%), to adjust PD drugs (patients: 28%, caregivers: 43%), and increase salt intake (patients: 27%, caregivers: 20%); however, 25% of patients and 9% of caregivers reported that no interventions were recommended. Medication ever being prescribed to treat nOH was reported by 34% of patients and 45% of caregivers. Among patients treated, 79% of patients (216/272) and 71% of caregivers (79/112) said that symptoms were somewhat to very well managed. Conclusions: Survey findings suggest the need for increased awareness of nOH and engagement with patients and caregivers regarding symptom management. A variety of interventions were recommended; no single treatment approach was noted. Respondents being treated felt nOH symptoms were at least somewhat well managed with treatment. Study Supported by: Lundbeck Disclosure: Dr. Hewitt has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Employee of Lundbeck. Dr. Adler has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Acadia, Acorda, Adamas, Jazz, Lundbeck, Neurocrine, Revance, Scion, and Sunovion. Dr. Claassen has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Teva Neuroscience, Lundbeck, Acadia, AbbVie. Dr. Claassen has received research support from NIH/NINDS, Michael J. Fox Foundation, Huntington Disease Society of America, Vaccinex, AbbVie, Auspex Pharmaceuticals. Dr. Gibbons has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Lundbeck Inc. Dr. Raj has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Consultant/Advisory Board: Lundbeck, GE Healthcare, Allergan." @default.
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• W2896433735 date "2018-04-10" @default.
• W2896433735 modified "2023-09-26" @default.
• W2896433735 title "Management and Treatment of Neurogenic Orthostatic Hypotension: Results From a Survey of Patients and Caregivers (P2.130)" @default.
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