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• W2896435444 abstract "Most cells spend the majority of their life in a non-proliferating state. When proliferation cessation is irreversible, cells are senescent. By contrast, if the arrest is only temporary, cells are defined as quiescent. These cellular states are hardly distinguishable without triggering proliferation resumption, hampering thus the study of quiescent cells properties. Here we show that quiescent and senescent yeast cells are recognizable based on their mitochondrial network morphology. Indeed, while quiescent yeast cells display numerous small vesicular mitochondria, senescent cells exhibit few globular mitochondria. This allowed us to reconsider at the individual-cell level, properties previously attributed to quiescent cells using population-based approaches. We demonstrate that cell's propensity to enter quiescence is not influenced by replicative age, volume or density. Overall, our findings reveal that quiescent cells are not all identical but that their ability to survive is significantly improved when they exhibit the specific reorganization of several cellular machineries." @default.
• W2896435444 created "2018-10-26" @default.
• W2896435444 creator A5013292140 @default.
• W2896435444 creator A5023400429 @default.
• W2896435444 creator A5041352491 @default.
• W2896435444 creator A5058559220 @default.
• W2896435444 creator A5089395758 @default.
• W2896435444 date "2018-10-09" @default.
• W2896435444 modified "2023-10-18" @default.
• W2896435444 title "Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate" @default.
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