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• W2896437143 abstract "Abstract Studies of polymorphonuclear leukocyte (PMN) functions in small animals have primarily been limited to elicited peritoneal PMNs. We have developed a model of induced acute inflammation in rats that provides a means of studying the functions of circulating PMNs. Using this model, we studied the influence of zinc deficiency on the chemotactic and respiratory burst capabilities of circulating PMNs responding to an inflammatory stimuli. Male rats were fed a zinc deficient (Zn-D) diet (0.5 μg Zn/g) or a control diet (25 μg Zn/g) either ad libitum (C) or in restricted amounts (R-C) for 6 weeks. PMNs were elicited by an intraperitoneal injection of glycogen and the circulating PMN response monitored for 4 h. The kinetics of peripheral blood PMN response were similar in all the groups, with the peak response time (cell number) at 2 h post-stimulation. Zinc deficiency was associated with an elevated baseline PMN concentration, as well as, an increase in the total number of circulating PMN. PMN function st..." @default.
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• W2896437143 date "1995-01-01" @default.
• W2896437143 modified "2023-09-22" @default.
• W2896437143 title "Alterations in the chemotactic and respiratory burst responses of peripheral blood neutrophils from zinc deficient rats" @default.
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