Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896440263> ?p ?o ?g. }
- W2896440263 endingPage "15856" @default.
- W2896440263 startingPage "15852" @default.
- W2896440263 abstract "A chemobiocatalytic strategy for the highly stereoselective synthesis of nitrile-substituted cyclopropanes is reported. The present approach relies on an asymmetric olefin cyclopropanation reaction catalyzed by an engineered myoglobin in the presence of ex situ generated diazoacetonitrile within a compartmentalized reaction system. This method enabled the efficient transformation of a broad range of olefin substrates at a preparative scale with up to 99.9 % de and ee and up to 5600 turnovers. The enzymatic product could be further elaborated to afford a variety of functionalized chiral cyclopropanes. This work expands the range of synthetically valuable, abiotic transformations accessible through biocatalysis and paves the way to the practical and safe exploitation of diazoacetonitrile in biocatalytic carbene transfer reactions." @default.
- W2896440263 created "2018-10-26" @default.
- W2896440263 creator A5065030796 @default.
- W2896440263 creator A5070780837 @default.
- W2896440263 date "2018-11-05" @default.
- W2896440263 modified "2023-10-16" @default.
- W2896440263 title "Highly Diastereo‐ and Enantioselective Synthesis of Nitrile‐Substituted Cyclopropanes by Myoglobin‐Mediated Carbene Transfer Catalysis" @default.
- W2896440263 cites W1031680929 @default.
- W2896440263 cites W1517975584 @default.
- W2896440263 cites W1779124664 @default.
- W2896440263 cites W1964284609 @default.
- W2896440263 cites W1969872919 @default.
- W2896440263 cites W1976236461 @default.
- W2896440263 cites W1980368805 @default.
- W2896440263 cites W1984180361 @default.
- W2896440263 cites W2010654750 @default.
- W2896440263 cites W2019131736 @default.
- W2896440263 cites W2038125839 @default.
- W2896440263 cites W2051341954 @default.
- W2896440263 cites W2075132137 @default.
- W2896440263 cites W2078531329 @default.
- W2896440263 cites W2086669701 @default.
- W2896440263 cites W2087195610 @default.
- W2896440263 cites W2091800127 @default.
- W2896440263 cites W2093196338 @default.
- W2896440263 cites W2099282718 @default.
- W2896440263 cites W2109937255 @default.
- W2896440263 cites W2112685446 @default.
- W2896440263 cites W2147111608 @default.
- W2896440263 cites W2152029656 @default.
- W2896440263 cites W2153810710 @default.
- W2896440263 cites W2210228437 @default.
- W2896440263 cites W2415341105 @default.
- W2896440263 cites W2422726141 @default.
- W2896440263 cites W2552624942 @default.
- W2896440263 cites W2600461956 @default.
- W2896440263 cites W2603561992 @default.
- W2896440263 cites W2605872533 @default.
- W2896440263 cites W2606434080 @default.
- W2896440263 cites W2607108385 @default.
- W2896440263 cites W2609124946 @default.
- W2896440263 cites W2617558546 @default.
- W2896440263 cites W2620546838 @default.
- W2896440263 cites W2687141720 @default.
- W2896440263 cites W2761771359 @default.
- W2896440263 cites W2762701237 @default.
- W2896440263 cites W2769349650 @default.
- W2896440263 cites W2770854189 @default.
- W2896440263 cites W2780590919 @default.
- W2896440263 cites W2785178119 @default.
- W2896440263 cites W2786747858 @default.
- W2896440263 cites W2788411992 @default.
- W2896440263 cites W2800695561 @default.
- W2896440263 cites W2950797181 @default.
- W2896440263 cites W2951186299 @default.
- W2896440263 cites W4213420553 @default.
- W2896440263 cites W4243698392 @default.
- W2896440263 cites W4244812902 @default.
- W2896440263 cites W4248601741 @default.
- W2896440263 cites W4254038820 @default.
- W2896440263 doi "https://doi.org/10.1002/anie.201810059" @default.
- W2896440263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6436623" @default.
- W2896440263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300955" @default.
- W2896440263 hasPublicationYear "2018" @default.
- W2896440263 type Work @default.
- W2896440263 sameAs 2896440263 @default.
- W2896440263 citedByCount "66" @default.
- W2896440263 countsByYear W28964402632018 @default.
- W2896440263 countsByYear W28964402632019 @default.
- W2896440263 countsByYear W28964402632020 @default.
- W2896440263 countsByYear W28964402632021 @default.
- W2896440263 countsByYear W28964402632022 @default.
- W2896440263 countsByYear W28964402632023 @default.
- W2896440263 crossrefType "journal-article" @default.
- W2896440263 hasAuthorship W2896440263A5065030796 @default.
- W2896440263 hasAuthorship W2896440263A5070780837 @default.
- W2896440263 hasBestOaLocation W28964402632 @default.
- W2896440263 hasConcept C146686406 @default.
- W2896440263 hasConcept C161790260 @default.
- W2896440263 hasConcept C178790620 @default.
- W2896440263 hasConcept C185592680 @default.
- W2896440263 hasConcept C191503008 @default.
- W2896440263 hasConcept C21951064 @default.
- W2896440263 hasConcept C2777052750 @default.
- W2896440263 hasConcept C2777164566 @default.
- W2896440263 hasConcept C2778063876 @default.
- W2896440263 hasConcept C2779240715 @default.
- W2896440263 hasConcept C51886252 @default.
- W2896440263 hasConcept C65024703 @default.
- W2896440263 hasConceptScore W2896440263C146686406 @default.
- W2896440263 hasConceptScore W2896440263C161790260 @default.
- W2896440263 hasConceptScore W2896440263C178790620 @default.
- W2896440263 hasConceptScore W2896440263C185592680 @default.
- W2896440263 hasConceptScore W2896440263C191503008 @default.
- W2896440263 hasConceptScore W2896440263C21951064 @default.
- W2896440263 hasConceptScore W2896440263C2777052750 @default.
- W2896440263 hasConceptScore W2896440263C2777164566 @default.
- W2896440263 hasConceptScore W2896440263C2778063876 @default.