Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896444158> ?p ?o ?g. }
- W2896444158 endingPage "16401" @default.
- W2896444158 startingPage "16390" @default.
- W2896444158 abstract "Glutamine is a key nutrient required for sustaining cell proliferation, contributing to nucleotide, protein, and lipid synthesis. The mTOR complex 1 (mTORC1) is a highly conserved protein complex that acts as a sensor of nutrients, relaying signals for the shift from catabolic to anabolic metabolism. Although glutamine plays an important role in mTORC1 activation, the mechanism is not clear. Here we describe a leucine- and Rag-independent mechanism of mTORC1 activation by glutamine that depends on phospholipase D and the production of phosphatidic acid, which is required for the stability and activity of mTORC1. The phospholipase D–dependent activation of mTORC1 by glutamine depended on the GTPases ADP ribosylation factor 1 (Arf1), RalA, and Rheb. Glutamine deprivation could be rescued by α-ketoglutarate, a downstream metabolite of glutamine. This mechanism represents a distinct nutrient input to mTORC1 that is independent of Rag GTPases and leucine." @default.
- W2896444158 created "2018-10-26" @default.
- W2896444158 creator A5007422892 @default.
- W2896444158 creator A5008064590 @default.
- W2896444158 creator A5035991860 @default.
- W2896444158 creator A5047275785 @default.
- W2896444158 creator A5067296755 @default.
- W2896444158 creator A5075304957 @default.
- W2896444158 creator A5078202231 @default.
- W2896444158 date "2018-10-01" @default.
- W2896444158 modified "2023-10-15" @default.
- W2896444158 title "Phospholipase D–dependent mTOR complex 1 (mTORC1) activation by glutamine" @default.
- W2896444158 cites W1973834617 @default.
- W2896444158 cites W1976331372 @default.
- W2896444158 cites W1980502224 @default.
- W2896444158 cites W1981596240 @default.
- W2896444158 cites W1992962914 @default.
- W2896444158 cites W1993159760 @default.
- W2896444158 cites W1995874255 @default.
- W2896444158 cites W2000731858 @default.
- W2896444158 cites W2014988241 @default.
- W2896444158 cites W2017996683 @default.
- W2896444158 cites W2024182435 @default.
- W2896444158 cites W2025176940 @default.
- W2896444158 cites W2045016256 @default.
- W2896444158 cites W2048906476 @default.
- W2896444158 cites W2050539911 @default.
- W2896444158 cites W2059986736 @default.
- W2896444158 cites W2081869055 @default.
- W2896444158 cites W2086562476 @default.
- W2896444158 cites W2086816631 @default.
- W2896444158 cites W2090406819 @default.
- W2896444158 cites W2114956843 @default.
- W2896444158 cites W2117026649 @default.
- W2896444158 cites W2117692326 @default.
- W2896444158 cites W2119392009 @default.
- W2896444158 cites W2123310132 @default.
- W2896444158 cites W2124598062 @default.
- W2896444158 cites W2127063807 @default.
- W2896444158 cites W2127584960 @default.
- W2896444158 cites W2137470659 @default.
- W2896444158 cites W2147494386 @default.
- W2896444158 cites W2157760261 @default.
- W2896444158 cites W2169903226 @default.
- W2896444158 cites W2277073486 @default.
- W2896444158 cites W2415181728 @default.
- W2896444158 cites W2589276620 @default.
- W2896444158 cites W2737869011 @default.
- W2896444158 cites W2739470863 @default.
- W2896444158 cites W2791714586 @default.
- W2896444158 cites W3117975060 @default.
- W2896444158 doi "https://doi.org/10.1074/jbc.ra118.004972" @default.
- W2896444158 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200938" @default.
- W2896444158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30194281" @default.
- W2896444158 hasPublicationYear "2018" @default.
- W2896444158 type Work @default.
- W2896444158 sameAs 2896444158 @default.
- W2896444158 citedByCount "36" @default.
- W2896444158 countsByYear W28964441582019 @default.
- W2896444158 countsByYear W28964441582020 @default.
- W2896444158 countsByYear W28964441582021 @default.
- W2896444158 countsByYear W28964441582022 @default.
- W2896444158 countsByYear W28964441582023 @default.
- W2896444158 crossrefType "journal-article" @default.
- W2896444158 hasAuthorship W2896444158A5007422892 @default.
- W2896444158 hasAuthorship W2896444158A5008064590 @default.
- W2896444158 hasAuthorship W2896444158A5035991860 @default.
- W2896444158 hasAuthorship W2896444158A5047275785 @default.
- W2896444158 hasAuthorship W2896444158A5067296755 @default.
- W2896444158 hasAuthorship W2896444158A5075304957 @default.
- W2896444158 hasAuthorship W2896444158A5078202231 @default.
- W2896444158 hasBestOaLocation W28964441581 @default.
- W2896444158 hasConcept C12927208 @default.
- W2896444158 hasConcept C181199279 @default.
- W2896444158 hasConcept C185592680 @default.
- W2896444158 hasConcept C2779349466 @default.
- W2896444158 hasConcept C515207424 @default.
- W2896444158 hasConcept C55493867 @default.
- W2896444158 hasConcept C6182249 @default.
- W2896444158 hasConcept C62478195 @default.
- W2896444158 hasConcept C86554907 @default.
- W2896444158 hasConcept C86803240 @default.
- W2896444158 hasConcept C95444343 @default.
- W2896444158 hasConcept C98490376 @default.
- W2896444158 hasConceptScore W2896444158C12927208 @default.
- W2896444158 hasConceptScore W2896444158C181199279 @default.
- W2896444158 hasConceptScore W2896444158C185592680 @default.
- W2896444158 hasConceptScore W2896444158C2779349466 @default.
- W2896444158 hasConceptScore W2896444158C515207424 @default.
- W2896444158 hasConceptScore W2896444158C55493867 @default.
- W2896444158 hasConceptScore W2896444158C6182249 @default.
- W2896444158 hasConceptScore W2896444158C62478195 @default.
- W2896444158 hasConceptScore W2896444158C86554907 @default.
- W2896444158 hasConceptScore W2896444158C86803240 @default.
- W2896444158 hasConceptScore W2896444158C95444343 @default.
- W2896444158 hasConceptScore W2896444158C98490376 @default.
- W2896444158 hasFunder F4320337351 @default.
- W2896444158 hasFunder F4320337375 @default.