FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896444299> ?p ?o ?g. }

• W2896444299 endingPage "101042831880493" @default.
• W2896444299 startingPage "101042831880493" @default.
• W2896444299 abstract "Ovarian cancer remains the most lethal gynecologic malignancy. This is due to lack of effective screening, diagnosis predominance in late stage of disease, a high recurrence rate after primary therapy, and poor treatment response in platinum-resistant tumor. Thus, unique biomarkers, predictive of individual disease course, and prognosis are urgently needed. The aim of our study was to assess the clinicopathological significance of plasma, peritoneal fluid, and tumor tissue levels of mesothelin in epithelial ovarian cancer patients. Plasma and peritoneal fluid levels of mesothelin were measured by enzyme-linked immunosorbent assay. Tissue expression of MSLN was evaluated using quantitative real-time polymerase chain reaction. Preoperative plasma mesothelin levels were significantly higher in epithelial ovarian cancer patients in comparison to the patients with benign tumor and controls. There have been noticed significant differences in the plasma mesothelin levels based on International Federation of Gynecology and Obstetrics stage, grade, and histology type. No significant changes were observed between Kurman and Shih type I versus type II epithelial ovarian cancer. Interestingly, peritoneal fluid mesothelin levels revealed significant differences based on both grade and Kurman and Shih–type epithelial ovarian cancer. There were no relevant changes in the mesothelin level in peritoneal fluid between different stages and histology types compared to benign tumor. MSLN expression level in tumor tissue was significantly higher based on stage, grade, and Kurman and Shih–type epithelial ovarian cancer than in the benign masses. In addition, data showed significant higher MSLN expression in endometrioid tumors compared to benign masses and serous tumors. Plasma, peritoneal fluid, and tumor tissue levels of mesothelin positively correlated with level of CA125. Low mesothelin concentrations in plasma were also associated with prolonged patient survival. More importantly, we revealed that plasma mesothelin level was correlated with both peritoneal fluid mesothelin level and tumor MSLN expression. This study highlights that plasma mesothelin level may be a useful noninvasive biomarker surrogate for local tumor mesothelin status in monitoring of epithelial ovarian cancer patients." @default.
• W2896444299 created "2018-10-26" @default.
• W2896444299 creator A5006727344 @default.
• W2896444299 creator A5010803116 @default.
• W2896444299 creator A5014922771 @default.
• W2896444299 creator A5032323222 @default.
• W2896444299 creator A5036541627 @default.
• W2896444299 creator A5038671158 @default.
• W2896444299 creator A5042138196 @default.
• W2896444299 creator A5072841264 @default.
• W2896444299 date "2018-10-15" @default.
• W2896444299 modified "2023-09-23" @default.
• W2896444299 title "Assessment of the clinicopathological relevance of mesothelin level in plasma, peritoneal fluid, and tumor tissue of epithelial ovarian cancer patients" @default.
• W2896444299 cites W1926256541 @default.
• W2896444299 cites W1940023041 @default.
• W2896444299 cites W1961928411 @default.
• W2896444299 cites W1965063641 @default.
• W2896444299 cites W1969194497 @default.
• W2896444299 cites W1972397907 @default.
• W2896444299 cites W1979568379 @default.
• W2896444299 cites W1984978403 @default.
• W2896444299 cites W1985613060 @default.
• W2896444299 cites W2003541535 @default.
• W2896444299 cites W2034301742 @default.
• W2896444299 cites W2035038195 @default.
• W2896444299 cites W2048572064 @default.
• W2896444299 cites W2050396069 @default.
• W2896444299 cites W2079891550 @default.
• W2896444299 cites W2081553250 @default.
• W2896444299 cites W2086757750 @default.
• W2896444299 cites W2098128190 @default.
• W2896444299 cites W2102596101 @default.
• W2896444299 cites W2110239006 @default.
• W2896444299 cites W2117688944 @default.
• W2896444299 cites W2128447288 @default.
• W2896444299 cites W2128548077 @default.
• W2896444299 cites W2129355295 @default.
• W2896444299 cites W2137634365 @default.
• W2896444299 cites W2152589130 @default.
• W2896444299 cites W2154363908 @default.
• W2896444299 cites W2158258441 @default.
• W2896444299 cites W2158490288 @default.
• W2896444299 cites W2160261768 @default.
• W2896444299 cites W2235523093 @default.
• W2896444299 cites W2305551225 @default.
• W2896444299 cites W2399370948 @default.
• W2896444299 cites W2521096873 @default.
• W2896444299 cites W2531335004 @default.
• W2896444299 cites W2584758038 @default.
• W2896444299 cites W2595525832 @default.
• W2896444299 cites W2623450661 @default.
• W2896444299 cites W2769983452 @default.
• W2896444299 cites W2771386655 @default.
• W2896444299 cites W2778095406 @default.
• W2896444299 cites W2784242077 @default.
• W2896444299 doi "https://doi.org/10.1177/1010428318804937" @default.
• W2896444299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30319054" @default.
• W2896444299 hasPublicationYear "2018" @default.
• W2896444299 type Work @default.
• W2896444299 sameAs 2896444299 @default.
• W2896444299 citedByCount "15" @default.
• W2896444299 countsByYear W28964442992019 @default.
• W2896444299 countsByYear W28964442992020 @default.
• W2896444299 countsByYear W28964442992021 @default.
• W2896444299 countsByYear W28964442992022 @default.
• W2896444299 countsByYear W28964442992023 @default.
• W2896444299 crossrefType "journal-article" @default.
• W2896444299 hasAuthorship W2896444299A5006727344 @default.
• W2896444299 hasAuthorship W2896444299A5010803116 @default.
• W2896444299 hasAuthorship W2896444299A5014922771 @default.
• W2896444299 hasAuthorship W2896444299A5032323222 @default.
• W2896444299 hasAuthorship W2896444299A5036541627 @default.
• W2896444299 hasAuthorship W2896444299A5038671158 @default.
• W2896444299 hasAuthorship W2896444299A5042138196 @default.
• W2896444299 hasAuthorship W2896444299A5072841264 @default.
• W2896444299 hasBestOaLocation W28964442991 @default.
• W2896444299 hasConcept C121608353 @default.
• W2896444299 hasConcept C126322002 @default.
• W2896444299 hasConcept C142724271 @default.
• W2896444299 hasConcept C143998085 @default.
• W2896444299 hasConcept C146357865 @default.
• W2896444299 hasConcept C150173356 @default.
• W2896444299 hasConcept C151730666 @default.
• W2896444299 hasConcept C2777045440 @default.
• W2896444299 hasConcept C2780084626 @default.
• W2896444299 hasConcept C2780427987 @default.
• W2896444299 hasConcept C2781447364 @default.
• W2896444299 hasConcept C57742111 @default.
• W2896444299 hasConcept C63363279 @default.
• W2896444299 hasConcept C71924100 @default.
• W2896444299 hasConcept C86803240 @default.
• W2896444299 hasConcept C98055416 @default.
• W2896444299 hasConceptScore W2896444299C121608353 @default.
• W2896444299 hasConceptScore W2896444299C126322002 @default.
• W2896444299 hasConceptScore W2896444299C142724271 @default.
• W2896444299 hasConceptScore W2896444299C143998085 @default.
• W2896444299 hasConceptScore W2896444299C146357865 @default.
• W2896444299 hasConceptScore W2896444299C150173356 @default.

• next