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- W2896446106 abstract "We report novel artificial metalloenzymes (ArMs), containing tris(pyridylmethyl)amine (TPA), for the atom economic oxidation of lignin β-O-4 model compounds, using hydrogen peroxide. The protein scaffold alters the selectivity of the reaction from a low yielding cleavage reaction when using the parent Fe-tpa complex to a high yielding benzylic alcohol oxidation when using the complex incorporated into a protein scaffold, SCP-2L A100C. Engineering the protein scaffold to incorporate glutamic acid was found to improve the ArM activity, showing that rational design of the protein environment using metal binding amino acids can be a first step toward improving the overall activity of an artificial metalloenzyme." @default.
- W2896446106 created "2018-10-26" @default.
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- W2896446106 date "2018-10-10" @default.
- W2896446106 modified "2023-10-14" @default.
- W2896446106 title "Artificial Metalloenzymes as Catalysts for Oxidative Lignin Degradation" @default.
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- W2896446106 doi "https://doi.org/10.1021/acssuschemeng.8b03568" @default.
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