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• W2896446856 abstract "Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC." @default.
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• W2896446856 date "2018-09-30" @default.
• W2896446856 modified "2023-10-15" @default.
• W2896446856 title "Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer" @default.
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• W2896446856 doi "https://doi.org/10.5808/gi.2018.16.3.71" @default.
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