Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896450672> ?p ?o ?g. }
- W2896450672 abstract "This review provides an overview on different antibody test methods that can be applied in cases of suspected paraneoplastic neurological syndromes (PNS) and anti-neuronal autoimmune encephalitis (AIE) in order to explain their diagnostic value, describe potential pitfalls and limitations, and discuss novel approaches aimed at discovering further autoantibodies. Onconeuronal antibodies are well-established biomarkers for PNS and may serve as specific tumor markers. The recommended procedure to detect onconeuronal antibodies is a combination of indirect immunohistochemistry on fixed rodent cerebellum and confirmation of the specificity by line assays. Simplification of this approach by only using line assays with recombinant proteins bears the risk to miss antibody-positive samples. Anti-neuronal surface antibodies are sensitive and specific biomarkers for AIE. Their identification requires the use of test methods that allow the recognition of conformation dependent epitopes. These commonly include cell-based assays and tissue based assays with unfixed rodent brain tissue. Tissue based assays can detect most of the currently known neuronal surface antibodies and thus enable broad screening of biological samples. A complementary testing on live neuronal cell cultures may confirm that the antibody recognizes a surface epitope. In patients with peripheral neuropathy, the screening may be expanded to teased nerve fibers to identify antibodies against the node of Ranvier. This method helps to identify a novel subgroup of peripheral autoimmune neuropathies, resulting in improved immunotherapy of these patients. Tissue based assays are useful to discover additional autoantibody targets that play a role in diverse autoimmune neurological syndromes. Antibody screening assays represent promising avenues of research to improve the diagnostic yield of current assays for antibody-associated autoimmune encephalitis." @default.
- W2896450672 created "2018-10-26" @default.
- W2896450672 creator A5002641079 @default.
- W2896450672 creator A5007213571 @default.
- W2896450672 creator A5027475416 @default.
- W2896450672 creator A5034197878 @default.
- W2896450672 creator A5040439766 @default.
- W2896450672 creator A5050882757 @default.
- W2896450672 creator A5054857624 @default.
- W2896450672 creator A5065860818 @default.
- W2896450672 creator A5074285440 @default.
- W2896450672 creator A5075292117 @default.
- W2896450672 creator A5077296742 @default.
- W2896450672 creator A5083474896 @default.
- W2896450672 date "2018-10-10" @default.
- W2896450672 modified "2023-10-15" @default.
- W2896450672 title "Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis" @default.
- W2896450672 cites W1566573763 @default.
- W2896450672 cites W1856657326 @default.
- W2896450672 cites W1884048683 @default.
- W2896450672 cites W1894872962 @default.
- W2896450672 cites W1923933944 @default.
- W2896450672 cites W1967064220 @default.
- W2896450672 cites W1974212503 @default.
- W2896450672 cites W1976010346 @default.
- W2896450672 cites W1977346161 @default.
- W2896450672 cites W1977920771 @default.
- W2896450672 cites W1983650864 @default.
- W2896450672 cites W1993102668 @default.
- W2896450672 cites W2001783182 @default.
- W2896450672 cites W2009407518 @default.
- W2896450672 cites W2021865068 @default.
- W2896450672 cites W2022982318 @default.
- W2896450672 cites W2028332032 @default.
- W2896450672 cites W2029974888 @default.
- W2896450672 cites W2035530295 @default.
- W2896450672 cites W2040727763 @default.
- W2896450672 cites W2044834640 @default.
- W2896450672 cites W2045746485 @default.
- W2896450672 cites W2048977435 @default.
- W2896450672 cites W2050658165 @default.
- W2896450672 cites W2060778400 @default.
- W2896450672 cites W2061056490 @default.
- W2896450672 cites W2066039469 @default.
- W2896450672 cites W2068359998 @default.
- W2896450672 cites W2071047994 @default.
- W2896450672 cites W2075100237 @default.
- W2896450672 cites W2075802277 @default.
- W2896450672 cites W2078947806 @default.
- W2896450672 cites W2078990452 @default.
- W2896450672 cites W2092226919 @default.
- W2896450672 cites W2094929674 @default.
- W2896450672 cites W2098001563 @default.
- W2896450672 cites W2099917041 @default.
- W2896450672 cites W2102311333 @default.
- W2896450672 cites W2103644035 @default.
- W2896450672 cites W2111470622 @default.
- W2896450672 cites W2112605335 @default.
- W2896450672 cites W2120238028 @default.
- W2896450672 cites W2125383082 @default.
- W2896450672 cites W2125799629 @default.
- W2896450672 cites W2126104297 @default.
- W2896450672 cites W2128597204 @default.
- W2896450672 cites W2129229339 @default.
- W2896450672 cites W2137421560 @default.
- W2896450672 cites W2141283639 @default.
- W2896450672 cites W2144469764 @default.
- W2896450672 cites W2146572660 @default.
- W2896450672 cites W2154982729 @default.
- W2896450672 cites W2156313095 @default.
- W2896450672 cites W2157547060 @default.
- W2896450672 cites W2163022996 @default.
- W2896450672 cites W2174733793 @default.
- W2896450672 cites W2182301760 @default.
- W2896450672 cites W2196709345 @default.
- W2896450672 cites W2280783985 @default.
- W2896450672 cites W2313719618 @default.
- W2896450672 cites W2327060038 @default.
- W2896450672 cites W2327130336 @default.
- W2896450672 cites W2343427124 @default.
- W2896450672 cites W2494661094 @default.
- W2896450672 cites W2506661329 @default.
- W2896450672 cites W2508852886 @default.
- W2896450672 cites W2515927283 @default.
- W2896450672 cites W2519077753 @default.
- W2896450672 cites W2528067317 @default.
- W2896450672 cites W2545267953 @default.
- W2896450672 cites W2581091689 @default.
- W2896450672 cites W2595114075 @default.
- W2896450672 cites W2618637635 @default.
- W2896450672 cites W2729031519 @default.
- W2896450672 cites W2736190034 @default.
- W2896450672 cites W2766618560 @default.
- W2896450672 cites W2766753632 @default.
- W2896450672 cites W2767386734 @default.
- W2896450672 cites W2789766907 @default.
- W2896450672 cites W2790682074 @default.
- W2896450672 cites W2791304973 @default.
- W2896450672 cites W2795316771 @default.
- W2896450672 cites W4237377959 @default.