Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896460480> ?p ?o ?g. }
- W2896460480 endingPage "1358" @default.
- W2896460480 startingPage "1352" @default.
- W2896460480 abstract "Public and private human stem cell banking institutions are currently hosting hundreds of thousands partially characterized cell populations, including a significant number of human pluripotent stem cell lines. To be considered for use in clinical applications, stem cell preparations must undergo rigorous testing in order to ensure safety for the recipient. With development of the methodologies for in vitro derivation, ex vivo maintenance and expansion of stem cells and targeted differentiation of multipotent and pluripotent stem cells, many novel issues were added to the list of safety concerns of cell and tissue preparations. These issues are related to the potential changes that may occur in the course of in vitro propagation of stem cells and cell-derived products, how these changes may affect the quality of the preparation; and the potential effects on the recipient. Only a limited number of studies about the role of subtle variations of individual capacity for repair of genotoxic damage in maintenance in vitro of human stem cells are currently available. Nevertheless, the assessment of individual repair capacity may play a crucial role in the safety of use of human stem cells, as it constitutes a major factor in the risk of occurrence of genomic alterations that may seriously compromise the quality of the product. This article reviews the available data about the role of individual capacity for DNA damage repair in different human stem cell types and the potential adverse effects that may occur with the use of cell preparations with inferior repair capacity." @default.
- W2896460480 created "2018-10-26" @default.
- W2896460480 creator A5009253250 @default.
- W2896460480 creator A5011846754 @default.
- W2896460480 creator A5019324330 @default.
- W2896460480 creator A5083500704 @default.
- W2896460480 date "2018-10-15" @default.
- W2896460480 modified "2023-09-27" @default.
- W2896460480 title "Individual capacity for repair of DNA damage and potential uses of stem cell lines for clinical applications: a matter of (genomic) integrity" @default.
- W2896460480 cites W1436283894 @default.
- W2896460480 cites W1496507033 @default.
- W2896460480 cites W1502981552 @default.
- W2896460480 cites W1592038665 @default.
- W2896460480 cites W1972334415 @default.
- W2896460480 cites W1977075613 @default.
- W2896460480 cites W1987774343 @default.
- W2896460480 cites W1990975754 @default.
- W2896460480 cites W2010099039 @default.
- W2896460480 cites W2017303317 @default.
- W2896460480 cites W2019136948 @default.
- W2896460480 cites W2022489847 @default.
- W2896460480 cites W2025092145 @default.
- W2896460480 cites W2029584195 @default.
- W2896460480 cites W2035894025 @default.
- W2896460480 cites W2036933277 @default.
- W2896460480 cites W2038160639 @default.
- W2896460480 cites W2041773411 @default.
- W2896460480 cites W2049899116 @default.
- W2896460480 cites W2053549853 @default.
- W2896460480 cites W2056392359 @default.
- W2896460480 cites W2059681949 @default.
- W2896460480 cites W2066413879 @default.
- W2896460480 cites W2072140342 @default.
- W2896460480 cites W2072990456 @default.
- W2896460480 cites W2082555884 @default.
- W2896460480 cites W2091617602 @default.
- W2896460480 cites W2095794256 @default.
- W2896460480 cites W2096559217 @default.
- W2896460480 cites W2108525884 @default.
- W2896460480 cites W2115750869 @default.
- W2896460480 cites W2120043123 @default.
- W2896460480 cites W2123750457 @default.
- W2896460480 cites W2134964344 @default.
- W2896460480 cites W2141161267 @default.
- W2896460480 cites W2149884610 @default.
- W2896460480 cites W2151935916 @default.
- W2896460480 cites W2177386097 @default.
- W2896460480 cites W2224831948 @default.
- W2896460480 cites W2271658056 @default.
- W2896460480 cites W2433194724 @default.
- W2896460480 cites W2461874209 @default.
- W2896460480 cites W2508821115 @default.
- W2896460480 cites W2516611503 @default.
- W2896460480 cites W2602668332 @default.
- W2896460480 cites W2616516736 @default.
- W2896460480 cites W2617221318 @default.
- W2896460480 cites W2617286375 @default.
- W2896460480 cites W2618949621 @default.
- W2896460480 cites W2626808697 @default.
- W2896460480 cites W2772451738 @default.
- W2896460480 cites W2795087713 @default.
- W2896460480 cites W2795372525 @default.
- W2896460480 cites W2912475757 @default.
- W2896460480 cites W4234309009 @default.
- W2896460480 cites W4248631980 @default.
- W2896460480 doi "https://doi.org/10.1080/13102818.2018.1520611" @default.
- W2896460480 hasPublicationYear "2018" @default.
- W2896460480 type Work @default.
- W2896460480 sameAs 2896460480 @default.
- W2896460480 citedByCount "2" @default.
- W2896460480 countsByYear W28964604802019 @default.
- W2896460480 countsByYear W28964604802022 @default.
- W2896460480 crossrefType "journal-article" @default.
- W2896460480 hasAuthorship W2896460480A5009253250 @default.
- W2896460480 hasAuthorship W2896460480A5011846754 @default.
- W2896460480 hasAuthorship W2896460480A5019324330 @default.
- W2896460480 hasAuthorship W2896460480A5083500704 @default.
- W2896460480 hasBestOaLocation W28964604801 @default.
- W2896460480 hasConcept C104317684 @default.
- W2896460480 hasConcept C107459253 @default.
- W2896460480 hasConcept C134935766 @default.
- W2896460480 hasConcept C145103041 @default.
- W2896460480 hasConcept C150903083 @default.
- W2896460480 hasConcept C201750760 @default.
- W2896460480 hasConcept C28328180 @default.
- W2896460480 hasConcept C2910776680 @default.
- W2896460480 hasConcept C54355233 @default.
- W2896460480 hasConcept C552990157 @default.
- W2896460480 hasConcept C86803240 @default.
- W2896460480 hasConcept C95444343 @default.
- W2896460480 hasConceptScore W2896460480C104317684 @default.
- W2896460480 hasConceptScore W2896460480C107459253 @default.
- W2896460480 hasConceptScore W2896460480C134935766 @default.
- W2896460480 hasConceptScore W2896460480C145103041 @default.
- W2896460480 hasConceptScore W2896460480C150903083 @default.
- W2896460480 hasConceptScore W2896460480C201750760 @default.
- W2896460480 hasConceptScore W2896460480C28328180 @default.
- W2896460480 hasConceptScore W2896460480C2910776680 @default.