FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896461831> ?p ?o ?g. }

• W2896461831 endingPage "436" @default.
• W2896461831 startingPage "427" @default.
• W2896461831 abstract "Identifying markers of chronic kidney disease (CKD) that occur early in the disease process and are specific to loss of kidney function rather than other underlying causes of disease may allow earlier, more accurate identification of patients who will develop CKD. We therefore sought to identify diagnostic blood markers of early CKD that are caused by loss of kidney function by using an innovative reverse Mendelian randomization (MR) approach.We applied this technique to genetic and biomarker data from 4147 participants in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial, all with known type 2 diabetes, impaired fasting glucose, or impaired glucose tolerance. Two-sample MR was conducted using variants associated with creatinine-based eGFR (eGFRcrea) from the CKDGen Consortium (n = 133814) to estimate the effect of genetically decreased eGFRcrea on 238 serum biomarkers.With reverse MR, trefoil factor 3 (TFF3) was identified as a protein that is increased owing to decreased eGFRcrea (β = 1.86 SD per SD decrease eGFRcrea; 95% CI, 0.95-2.76; P = 8.0 × 10-5). Reverse MR findings were consistent with epidemiological associations for incident CKD in ORIGIN (OR = 1.28 per SD increase in TFF3; 95% CI, 1.18-1.38; P = 4.58 × 10-10). Addition of TFF3 significantly improved discrimination for incident CKD relative to eGFRcrea alone (net reclassification improvement = 0.211; P = 9.56 × 10-12) and in models including additional risk factors.Our results suggest TFF3 is a valuable diagnostic marker for early CKD in dysglycemic populations and acts as a proof of concept for the application of this novel MR technique to identify diagnostic biomarkers for other chronic diseases.NCT00069784." @default.
• W2896461831 created "2018-10-26" @default.
• W2896461831 creator A5013696488 @default.
• W2896461831 creator A5015456745 @default.
• W2896461831 creator A5015633756 @default.
• W2896461831 creator A5043842967 @default.
• W2896461831 creator A5054423486 @default.
• W2896461831 creator A5060545924 @default.
• W2896461831 creator A5075036743 @default.
• W2896461831 creator A5075405688 @default.
• W2896461831 creator A5084741348 @default.
• W2896461831 date "2019-03-01" @default.
• W2896461831 modified "2023-10-02" @default.
• W2896461831 title "A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease" @default.
• W2896461831 cites W1570583414 @default.
• W2896461831 cites W1905058580 @default.
• W2896461831 cites W1971392543 @default.
• W2896461831 cites W1992436001 @default.
• W2896461831 cites W1995996138 @default.
• W2896461831 cites W1997163211 @default.
• W2896461831 cites W2006617902 @default.
• W2896461831 cites W2033151532 @default.
• W2896461831 cites W2034275740 @default.
• W2896461831 cites W2036789134 @default.
• W2896461831 cites W2053943923 @default.
• W2896461831 cites W2078141382 @default.
• W2896461831 cites W2080040321 @default.
• W2896461831 cites W2087036932 @default.
• W2896461831 cites W2095948376 @default.
• W2896461831 cites W2098230963 @default.
• W2896461831 cites W2103783427 @default.
• W2896461831 cites W2104549677 @default.
• W2896461831 cites W2111346120 @default.
• W2896461831 cites W2117897510 @default.
• W2896461831 cites W2120798274 @default.
• W2896461831 cites W2133507189 @default.
• W2896461831 cites W2136160292 @default.
• W2896461831 cites W2161633633 @default.
• W2896461831 cites W2267726385 @default.
• W2896461831 cites W2291018248 @default.
• W2896461831 cites W2324062964 @default.
• W2896461831 cites W2336172225 @default.
• W2896461831 cites W2411709723 @default.
• W2896461831 cites W2465879182 @default.
• W2896461831 cites W2500767839 @default.
• W2896461831 cites W2724727304 @default.
• W2896461831 cites W2752707491 @default.
• W2896461831 cites W2753051611 @default.
• W2896461831 cites W2780162034 @default.
• W2896461831 cites W2793294907 @default.
• W2896461831 doi "https://doi.org/10.1373/clinchem.2018.291104" @default.
• W2896461831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30337280" @default.
• W2896461831 hasPublicationYear "2019" @default.
• W2896461831 type Work @default.
• W2896461831 sameAs 2896461831 @default.
• W2896461831 citedByCount "12" @default.
• W2896461831 countsByYear W28964618312019 @default.
• W2896461831 countsByYear W28964618312020 @default.
• W2896461831 countsByYear W28964618312021 @default.
• W2896461831 countsByYear W28964618312022 @default.
• W2896461831 countsByYear W28964618312023 @default.
• W2896461831 crossrefType "journal-article" @default.
• W2896461831 hasAuthorship W2896461831A5013696488 @default.
• W2896461831 hasAuthorship W2896461831A5015456745 @default.
• W2896461831 hasAuthorship W2896461831A5015633756 @default.
• W2896461831 hasAuthorship W2896461831A5043842967 @default.
• W2896461831 hasAuthorship W2896461831A5054423486 @default.
• W2896461831 hasAuthorship W2896461831A5060545924 @default.
• W2896461831 hasAuthorship W2896461831A5075036743 @default.
• W2896461831 hasAuthorship W2896461831A5075405688 @default.
• W2896461831 hasAuthorship W2896461831A5084741348 @default.
• W2896461831 hasBestOaLocation W28964618311 @default.
• W2896461831 hasConcept C104317684 @default.
• W2896461831 hasConcept C126322002 @default.
• W2896461831 hasConcept C134018914 @default.
• W2896461831 hasConcept C135763542 @default.
• W2896461831 hasConcept C143998085 @default.
• W2896461831 hasConcept C159641895 @default.
• W2896461831 hasConcept C168563851 @default.
• W2896461831 hasConcept C204243189 @default.
• W2896461831 hasConcept C2778653478 @default.
• W2896461831 hasConcept C2779134260 @default.
• W2896461831 hasConcept C2779901538 @default.
• W2896461831 hasConcept C2780306776 @default.
• W2896461831 hasConcept C2781197716 @default.
• W2896461831 hasConcept C2993967602 @default.
• W2896461831 hasConcept C54355233 @default.
• W2896461831 hasConcept C555293320 @default.
• W2896461831 hasConcept C71924100 @default.
• W2896461831 hasConcept C86803240 @default.
• W2896461831 hasConcept C90924648 @default.
• W2896461831 hasConceptScore W2896461831C104317684 @default.
• W2896461831 hasConceptScore W2896461831C126322002 @default.
• W2896461831 hasConceptScore W2896461831C134018914 @default.
• W2896461831 hasConceptScore W2896461831C135763542 @default.
• W2896461831 hasConceptScore W2896461831C143998085 @default.
• W2896461831 hasConceptScore W2896461831C159641895 @default.
• W2896461831 hasConceptScore W2896461831C168563851 @default.

• next