Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896465229> ?p ?o ?g. }
- W2896465229 abstract "The N-glycosylation of immunoglobulin (Ig) G, the major antibody in the circulation of human adults, is well known for its influences on antibody effector functions and its alterations with various diseases. In contrast, knowledge on the role of glycans attached to IgA, which is a key immune defense agent in secretions, is very scarce. In this study we aimed to characterize the glycosylation of salivary (secretory) IgA, including the IgA joining chain (JC) and secretory component (SC) and to compare IgA and IgG glycosylation between human plasma and saliva samples to gain a first insight into oral cavity-specific antibody glycosylation. Plasma and whole saliva were collected from 19 healthy volunteers within a two-hour time window. IgG and IgA were affinity-purified from the two biofluids, followed by tryptic digestion and nanoLC-ESI-QTOF-MS(/MS) analysis. Saliva-derived IgG exhibited a slightly lower galactosylation and sialylation as compared to plasma-derived IgG. Glycosylation of IgA1, IgA2 and the JC showed substantial differences between the biofluids, with salivary proteins exhibiting a higher bisection, and lower galactosylation and sialylation as compared to plasma-derived IgA and JC. Additionally, all seven N-glycosylation sites, characterized on the SC of secretory IgA in saliva, carried highly fucosylated and fully galactosylated diantennary N-glycans. This study lays the basis for future research into the functional role of salivary Ig glycosylation as well as its biomarker potential." @default.
- W2896465229 created "2018-10-26" @default.
- W2896465229 creator A5019883858 @default.
- W2896465229 creator A5046532037 @default.
- W2896465229 creator A5052090918 @default.
- W2896465229 creator A5055749310 @default.
- W2896465229 creator A5065397150 @default.
- W2896465229 creator A5084796767 @default.
- W2896465229 date "2018-10-23" @default.
- W2896465229 modified "2023-09-30" @default.
- W2896465229 title "Comparative Glycomics of Immunoglobulin A and G From Saliva and Plasma Reveals Biomarker Potential" @default.
- W2896465229 cites W1514173606 @default.
- W2896465229 cites W1750136410 @default.
- W2896465229 cites W1839631757 @default.
- W2896465229 cites W1874142858 @default.
- W2896465229 cites W1973283944 @default.
- W2896465229 cites W1975414229 @default.
- W2896465229 cites W1977432663 @default.
- W2896465229 cites W1979253260 @default.
- W2896465229 cites W1989015465 @default.
- W2896465229 cites W1995995495 @default.
- W2896465229 cites W2001048171 @default.
- W2896465229 cites W2008414196 @default.
- W2896465229 cites W2015918955 @default.
- W2896465229 cites W2019114457 @default.
- W2896465229 cites W2021442122 @default.
- W2896465229 cites W2025662169 @default.
- W2896465229 cites W2025937331 @default.
- W2896465229 cites W2026807922 @default.
- W2896465229 cites W2037260702 @default.
- W2896465229 cites W2046585466 @default.
- W2896465229 cites W2049381049 @default.
- W2896465229 cites W2055507506 @default.
- W2896465229 cites W2058178814 @default.
- W2896465229 cites W2060565977 @default.
- W2896465229 cites W2064418342 @default.
- W2896465229 cites W2069311788 @default.
- W2896465229 cites W2078946709 @default.
- W2896465229 cites W2080898036 @default.
- W2896465229 cites W2082991836 @default.
- W2896465229 cites W2083205212 @default.
- W2896465229 cites W2089644524 @default.
- W2896465229 cites W2090753095 @default.
- W2896465229 cites W2099993648 @default.
- W2896465229 cites W2100518445 @default.
- W2896465229 cites W2103723915 @default.
- W2896465229 cites W2108205511 @default.
- W2896465229 cites W2108223798 @default.
- W2896465229 cites W2123768348 @default.
- W2896465229 cites W2128200823 @default.
- W2896465229 cites W2135581618 @default.
- W2896465229 cites W2136722035 @default.
- W2896465229 cites W2140723605 @default.
- W2896465229 cites W2146612842 @default.
- W2896465229 cites W2154100133 @default.
- W2896465229 cites W2194553112 @default.
- W2896465229 cites W2217221998 @default.
- W2896465229 cites W2223966355 @default.
- W2896465229 cites W2306311420 @default.
- W2896465229 cites W2315989691 @default.
- W2896465229 cites W2317117980 @default.
- W2896465229 cites W2403702241 @default.
- W2896465229 cites W2412071739 @default.
- W2896465229 cites W2426477522 @default.
- W2896465229 cites W2442134451 @default.
- W2896465229 cites W2593781652 @default.
- W2896465229 cites W2724614472 @default.
- W2896465229 cites W2732552982 @default.
- W2896465229 cites W2741734362 @default.
- W2896465229 cites W2754240404 @default.
- W2896465229 cites W2789682399 @default.
- W2896465229 cites W2791959104 @default.
- W2896465229 cites W2794333295 @default.
- W2896465229 cites W2795795715 @default.
- W2896465229 cites W40840948 @default.
- W2896465229 cites W4210702584 @default.
- W2896465229 cites W4229696791 @default.
- W2896465229 doi "https://doi.org/10.3389/fimmu.2018.02436" @default.
- W2896465229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6206042" @default.
- W2896465229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405629" @default.
- W2896465229 hasPublicationYear "2018" @default.
- W2896465229 type Work @default.
- W2896465229 sameAs 2896465229 @default.
- W2896465229 citedByCount "54" @default.
- W2896465229 countsByYear W28964652292019 @default.
- W2896465229 countsByYear W28964652292020 @default.
- W2896465229 countsByYear W28964652292021 @default.
- W2896465229 countsByYear W28964652292022 @default.
- W2896465229 countsByYear W28964652292023 @default.
- W2896465229 crossrefType "journal-article" @default.
- W2896465229 hasAuthorship W2896465229A5019883858 @default.
- W2896465229 hasAuthorship W2896465229A5046532037 @default.
- W2896465229 hasAuthorship W2896465229A5052090918 @default.
- W2896465229 hasAuthorship W2896465229A5055749310 @default.
- W2896465229 hasAuthorship W2896465229A5065397150 @default.
- W2896465229 hasAuthorship W2896465229A5084796767 @default.
- W2896465229 hasBestOaLocation W28964652291 @default.
- W2896465229 hasConcept C106686826 @default.
- W2896465229 hasConcept C108625454 @default.
- W2896465229 hasConcept C159654299 @default.