FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896465708> ?p ?o ?g. }

• W2896465708 abstract "Abstract We studied photochemical reactions of Br U-substituted G-quadruplex (G4) DNA substrates with two pyrene-substituted polyazamacrocyclic ligands, M-1PY and M-2PY. Both ligands bind to and stabilize G4-DNA structures without altering their folding topology, as demonstrated by FRET-melting experiments, fluorimetric titrations and CD spectroscopy. Notably, the bis-pyrene derivative (M-2PY) behaves as a significantly more affine and selective G4 ligand, compared with its mono-pyrene counterpart (M-1PY) and control compounds. Upon short UVA irradiation (365 nm) both ligands, in particular M-2PY, efficiently sensitize photoreactions at Br U residues incorporated in G4 structures and give rise to two kinds of photoproducts, namely DNA strand cleavage and covalent ligand–DNA photoadducts. Remarkably, the photoinduced strand cleavage is observed exclusively with G4 structures presenting Br U residues in lateral or diagonal loops, but not with parallel G4-DNA structures presenting only propeller loops. In contrast, the formation of fluorescent photoadducts is observed with all Br U-substituted G4-DNA substrates, with M-2PY giving significantly higher yields (up to 27%) than M-1PY. Both ligand-sensitized photoreactions are specific to Br U-modified G4-DNA structures with respect to double-stranded or stem-loop substrates. Thus, ligand-sensitized photoreactions with Br U-substituted G4-DNA may be exploited (i) as a photochemical probe, allowing “photofootprinting” of G4 folding topologies in vitro and (ii) for covalent trapping of G4 structures as photoadducts with pyrene-substituted ligands." @default.
• W2896465708 created "2018-10-26" @default.
• W2896465708 creator A5019591347 @default.
• W2896465708 creator A5032046128 @default.
• W2896465708 creator A5033301289 @default.
• W2896465708 creator A5046831416 @default.
• W2896465708 date "2018-10-25" @default.
• W2896465708 modified "2023-10-10" @default.
• W2896465708 title "Probing of G-Quadruplex Structures via Ligand-Sensitized Photochemical Reactions in BrU-Substituted DNA" @default.
• W2896465708 cites W1450574606 @default.
• W2896465708 cites W1489967197 @default.
• W2896465708 cites W1914649288 @default.
• W2896465708 cites W1960108177 @default.
• W2896465708 cites W1965307977 @default.
• W2896465708 cites W1969453135 @default.
• W2896465708 cites W1977006678 @default.
• W2896465708 cites W1978685619 @default.
• W2896465708 cites W1981242534 @default.
• W2896465708 cites W1988631038 @default.
• W2896465708 cites W1990734596 @default.
• W2896465708 cites W1991580414 @default.
• W2896465708 cites W2001639580 @default.
• W2896465708 cites W2005594244 @default.
• W2896465708 cites W2007812774 @default.
• W2896465708 cites W2008182786 @default.
• W2896465708 cites W2018104916 @default.
• W2896465708 cites W2022433812 @default.
• W2896465708 cites W2026370504 @default.
• W2896465708 cites W2029468622 @default.
• W2896465708 cites W2029853777 @default.
• W2896465708 cites W2031467156 @default.
• W2896465708 cites W2044279725 @default.
• W2896465708 cites W2045868610 @default.
• W2896465708 cites W2050913592 @default.
• W2896465708 cites W2062724831 @default.
• W2896465708 cites W2064202280 @default.
• W2896465708 cites W2073083789 @default.
• W2896465708 cites W2075919627 @default.
• W2896465708 cites W2078604414 @default.
• W2896465708 cites W2082600364 @default.
• W2896465708 cites W2083703501 @default.
• W2896465708 cites W2089598395 @default.
• W2896465708 cites W2090924417 @default.
• W2896465708 cites W2095195375 @default.
• W2896465708 cites W2101109007 @default.
• W2896465708 cites W2113059992 @default.
• W2896465708 cites W2114289148 @default.
• W2896465708 cites W2119133826 @default.
• W2896465708 cites W2120424633 @default.
• W2896465708 cites W2121670421 @default.
• W2896465708 cites W2139032214 @default.
• W2896465708 cites W2149970393 @default.
• W2896465708 cites W2151329432 @default.
• W2896465708 cites W2166630132 @default.
• W2896465708 cites W2168332424 @default.
• W2896465708 cites W2169745877 @default.
• W2896465708 cites W2295900799 @default.
• W2896465708 cites W2320936920 @default.
• W2896465708 cites W2518362417 @default.
• W2896465708 cites W2520749639 @default.
• W2896465708 cites W2522261353 @default.
• W2896465708 cites W2550556736 @default.
• W2896465708 cites W2578239036 @default.
• W2896465708 cites W2805876309 @default.
• W2896465708 cites W1869537251 @default.
• W2896465708 doi "https://doi.org/10.1038/s41598-018-34141-z" @default.
• W2896465708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6202380" @default.
• W2896465708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30361545" @default.
• W2896465708 hasPublicationYear "2018" @default.
• W2896465708 type Work @default.
• W2896465708 sameAs 2896465708 @default.
• W2896465708 citedByCount "3" @default.
• W2896465708 countsByYear W28964657082020 @default.
• W2896465708 countsByYear W28964657082022 @default.
• W2896465708 crossrefType "journal-article" @default.
• W2896465708 hasAuthorship W2896465708A5019591347 @default.
• W2896465708 hasAuthorship W2896465708A5032046128 @default.
• W2896465708 hasAuthorship W2896465708A5033301289 @default.
• W2896465708 hasAuthorship W2896465708A5046831416 @default.
• W2896465708 hasBestOaLocation W28964657081 @default.
• W2896465708 hasConcept C116569031 @default.
• W2896465708 hasConcept C170493617 @default.
• W2896465708 hasConcept C178790620 @default.
• W2896465708 hasConcept C180577832 @default.
• W2896465708 hasConcept C185592680 @default.
• W2896465708 hasConcept C2778951431 @default.
• W2896465708 hasConcept C552990157 @default.
• W2896465708 hasConcept C55493867 @default.
• W2896465708 hasConcept C71240020 @default.
• W2896465708 hasConcept C75473681 @default.
• W2896465708 hasConceptScore W2896465708C116569031 @default.
• W2896465708 hasConceptScore W2896465708C170493617 @default.
• W2896465708 hasConceptScore W2896465708C178790620 @default.
• W2896465708 hasConceptScore W2896465708C180577832 @default.
• W2896465708 hasConceptScore W2896465708C185592680 @default.
• W2896465708 hasConceptScore W2896465708C2778951431 @default.
• W2896465708 hasConceptScore W2896465708C552990157 @default.
• W2896465708 hasConceptScore W2896465708C55493867 @default.
• W2896465708 hasConceptScore W2896465708C71240020 @default.
• W2896465708 hasConceptScore W2896465708C75473681 @default.

• next