Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896467715> ?p ?o ?g. }
- W2896467715 abstract "Mitochondrial functions are critical for cellular physiology; therefore, several conserved mechanisms are in place to maintain the functional integrity of mitochondria. However, many of the molecular details and components involved in ensuring mitochondrial fidelity remain obscure. Here we identify a novel role for the conserved mitochondrial AAA ATPase Afg1 in mediating mitochondrial protein homeostasis during aging and in response to various cellular challenges. Saccharomyces cerevisiae cells lacking functional Afg1 are hypersensitive to oxidative insults, unable to tolerate protein misfolding in the matrix compartment, and exhibit progressive mitochondrial failure as they age. Loss of Afg1 ortholog LACE-1 in Caenorhabditis elegans is associated with reduced lifespan, impeded oxidative stress tolerance, impaired mitochondrial proteostasis in motor neuron circuitry, and altered behavioral plasticity. Our results indicate that Afg1 is a novel protein quality control factor, which plays an important evolutionarily conserved role in mitochondrial surveillance and cellular and organismal healthspan." @default.
- W2896467715 created "2018-10-26" @default.
- W2896467715 creator A5010236361 @default.
- W2896467715 creator A5010775903 @default.
- W2896467715 creator A5057131918 @default.
- W2896467715 creator A5063463617 @default.
- W2896467715 creator A5075516950 @default.
- W2896467715 date "2018-01-01" @default.
- W2896467715 modified "2023-10-15" @default.
- W2896467715 title "AAA ATPase Afg1 preserves organellar fidelity and cellular healthspan by maintaining mitochondrial matrix proteostasis" @default.
- W2896467715 cites W1449793716 @default.
- W2896467715 cites W1551458475 @default.
- W2896467715 cites W1556017032 @default.
- W2896467715 cites W1926695909 @default.
- W2896467715 cites W1966072209 @default.
- W2896467715 cites W1967271835 @default.
- W2896467715 cites W1985760284 @default.
- W2896467715 cites W1996306443 @default.
- W2896467715 cites W1996476714 @default.
- W2896467715 cites W2004171820 @default.
- W2896467715 cites W2009885573 @default.
- W2896467715 cites W2012941238 @default.
- W2896467715 cites W2018659142 @default.
- W2896467715 cites W2020335617 @default.
- W2896467715 cites W2023922838 @default.
- W2896467715 cites W2023953172 @default.
- W2896467715 cites W2028717822 @default.
- W2896467715 cites W2036192672 @default.
- W2896467715 cites W2039750785 @default.
- W2896467715 cites W2041532203 @default.
- W2896467715 cites W2043603162 @default.
- W2896467715 cites W2043665352 @default.
- W2896467715 cites W2044677937 @default.
- W2896467715 cites W2048240388 @default.
- W2896467715 cites W2051223126 @default.
- W2896467715 cites W2051709136 @default.
- W2896467715 cites W2069739721 @default.
- W2896467715 cites W2070927743 @default.
- W2896467715 cites W2086356615 @default.
- W2896467715 cites W2090347940 @default.
- W2896467715 cites W2093785402 @default.
- W2896467715 cites W2100365580 @default.
- W2896467715 cites W2103856526 @default.
- W2896467715 cites W2109283736 @default.
- W2896467715 cites W2110361765 @default.
- W2896467715 cites W2117108451 @default.
- W2896467715 cites W2121431496 @default.
- W2896467715 cites W2122213881 @default.
- W2896467715 cites W2134001597 @default.
- W2896467715 cites W2141444248 @default.
- W2896467715 cites W2142957480 @default.
- W2896467715 cites W2143110748 @default.
- W2896467715 cites W2148738130 @default.
- W2896467715 cites W2150164439 @default.
- W2896467715 cites W2151427055 @default.
- W2896467715 cites W2152165298 @default.
- W2896467715 cites W2154046032 @default.
- W2896467715 cites W2154136145 @default.
- W2896467715 cites W2161235127 @default.
- W2896467715 cites W2272605083 @default.
- W2896467715 cites W2299595268 @default.
- W2896467715 cites W2322704766 @default.
- W2896467715 cites W2345724765 @default.
- W2896467715 cites W2412925739 @default.
- W2896467715 cites W2419742740 @default.
- W2896467715 cites W2524370798 @default.
- W2896467715 cites W2563505725 @default.
- W2896467715 cites W2592662044 @default.
- W2896467715 cites W2616401544 @default.
- W2896467715 cites W2735420073 @default.
- W2896467715 cites W2763915801 @default.
- W2896467715 cites W2809666506 @default.
- W2896467715 cites W4252308397 @default.
- W2896467715 doi "https://doi.org/10.1242/jcs.219956" @default.
- W2896467715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6262775" @default.
- W2896467715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301782" @default.
- W2896467715 hasPublicationYear "2018" @default.
- W2896467715 type Work @default.
- W2896467715 sameAs 2896467715 @default.
- W2896467715 citedByCount "7" @default.
- W2896467715 countsByYear W28964677152019 @default.
- W2896467715 countsByYear W28964677152020 @default.
- W2896467715 countsByYear W28964677152021 @default.
- W2896467715 countsByYear W28964677152022 @default.
- W2896467715 crossrefType "journal-article" @default.
- W2896467715 hasAuthorship W2896467715A5010236361 @default.
- W2896467715 hasAuthorship W2896467715A5010775903 @default.
- W2896467715 hasAuthorship W2896467715A5057131918 @default.
- W2896467715 hasAuthorship W2896467715A5063463617 @default.
- W2896467715 hasAuthorship W2896467715A5075516950 @default.
- W2896467715 hasBestOaLocation W28964677151 @default.
- W2896467715 hasConcept C101635128 @default.
- W2896467715 hasConcept C104317684 @default.
- W2896467715 hasConcept C181199279 @default.
- W2896467715 hasConcept C23265538 @default.
- W2896467715 hasConcept C2778944004 @default.
- W2896467715 hasConcept C2781452922 @default.
- W2896467715 hasConcept C28859421 @default.
- W2896467715 hasConcept C54355233 @default.
- W2896467715 hasConcept C55493867 @default.