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• W2896470548 abstract "In this work, the carbon-based microsphere with hollow-nanoflower structure was designed and applied to the targeted drug delivery system (TDDS) in order to improve drug loading and microwave control efficiency. We utilize the “silicon-assisted” method to tailor the hollow mesoporous carbon nanoflower (HMCNF) microspheres as base material, then small Fe3O4 particles (5–12 nm) were precipitated on the HMCNF by thermal decomposition and modified with SiO2 to obtain Fe3O4/HMCNF-SiO2 composites. The tailor-made Fe3O4/HMCNF-SiO2 has unique hollow “flower-dewdrops” structure, large BET surface area (292.21 m2/g) and uniform pore size (5.61 nm) to achieve large storage of drugs. Meanwhile, the Fe3O4/HMCNF-SiO2 has the appropriate magnetic properties (Ms = 8.91 emu/g) and good microwave heat transfer performance, which can achieve the drug carrier targeting and microwave-triggered release. Furthermore, the Fe3O4/HMCNF-SiO2 has a higher drug loading rate of 70.20% (DOX loading of 175.50 mg/g) and an expected release behavior. It maintains a very low drug release rate only 1.5% at pH = 7.4 and then increased to 25.2% after microwave stimulation at pH = 5.0. Therefore the Fe3O4/HMCNF-SiO2 composite nanocarrier is expected to widely use in microwave-triggered drug delivery system." @default.
• W2896470548 created "2018-10-26" @default.
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• W2896470548 date "2019-02-01" @default.
• W2896470548 modified "2023-10-10" @default.
• W2896470548 title "Preparation of flower-dewdrops Fe3O4/carbon-SiO2 microsphere for microwave-triggered drug delivery" @default.
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• W2896470548 doi "https://doi.org/10.1016/j.jallcom.2018.10.164" @default.
• W2896470548 hasPublicationYear "2019" @default.
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