Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896470597> ?p ?o ?g. }
- W2896470597 endingPage "1465" @default.
- W2896470597 startingPage "1449" @default.
- W2896470597 abstract "The function and clinical implication of transcription factor CCAAT/enhancer-binding protein α (C/EBPα) in colorectal cancer (CRC) still remains undefined. In fact, C/EBPα has long been considered as a tumor suppressor in hematopoietic system and also found lowly expressed in numerous solid tumors. However, our results here for the first time showed that C/EBPα was unexpectedly upregulated and was an independent prognostic marker for patients with CRC. We therefore aimed to explore the detailed role and mechanisms of C/EBPα in CRC. Our investigation demonstrated that C/EBPα promoted tumor growth both in vitro and in vivo. In addition, suppression of C/EBPα inhibited cell proliferation by inducing G1 phase arrest and inducing apoptosis. Also, C/EBPα enhances CRC cells migration and invasion in vitro as well as metastasis in vivo through regulating EMT. Mechanistically, C/EBPα exerts its oncogenic role by targeting c-Myc/cyclin D1 mediated by β-catenin involved pathway and we provide evidence indicating that cytoplasmic exclusion of C/EBPα might contribute to its oncogenic function in tumor progression. In conclusion, C/EBPα acts as an oncogene in CRC and could be a potential biomarker of colon carcinogenesis." @default.
- W2896470597 created "2018-10-26" @default.
- W2896470597 creator A5007409871 @default.
- W2896470597 creator A5011747309 @default.
- W2896470597 creator A5040623786 @default.
- W2896470597 creator A5048385740 @default.
- W2896470597 creator A5058673686 @default.
- W2896470597 creator A5059985657 @default.
- W2896470597 creator A5062384537 @default.
- W2896470597 creator A5078269576 @default.
- W2896470597 creator A5079618096 @default.
- W2896470597 date "2018-01-01" @default.
- W2896470597 modified "2023-09-25" @default.
- W2896470597 title "Upregulation of C/EBPα contributes to colorectal cancer growth, metastasis and indicates poor survival outcome." @default.
- W2896470597 cites W179818011 @default.
- W2896470597 cites W1964501434 @default.
- W2896470597 cites W1971106880 @default.
- W2896470597 cites W1971822297 @default.
- W2896470597 cites W1985824777 @default.
- W2896470597 cites W2005145657 @default.
- W2896470597 cites W2011429571 @default.
- W2896470597 cites W2012991143 @default.
- W2896470597 cites W2021198860 @default.
- W2896470597 cites W2026090704 @default.
- W2896470597 cites W2031483285 @default.
- W2896470597 cites W2031980017 @default.
- W2896470597 cites W2038912397 @default.
- W2896470597 cites W2042198997 @default.
- W2896470597 cites W2049296174 @default.
- W2896470597 cites W2049400611 @default.
- W2896470597 cites W2056302937 @default.
- W2896470597 cites W2063011414 @default.
- W2896470597 cites W2064541600 @default.
- W2896470597 cites W2076583198 @default.
- W2896470597 cites W2079398023 @default.
- W2896470597 cites W2083483484 @default.
- W2896470597 cites W2088354340 @default.
- W2896470597 cites W2100088478 @default.
- W2896470597 cites W2105250121 @default.
- W2896470597 cites W2115413477 @default.
- W2896470597 cites W2118103951 @default.
- W2896470597 cites W2121436678 @default.
- W2896470597 cites W2123592667 @default.
- W2896470597 cites W2126093778 @default.
- W2896470597 cites W2127632559 @default.
- W2896470597 cites W2131411117 @default.
- W2896470597 cites W2141096844 @default.
- W2896470597 cites W2152541039 @default.
- W2896470597 cites W2156583045 @default.
- W2896470597 cites W2159734298 @default.
- W2896470597 cites W2169615193 @default.
- W2896470597 cites W2171094329 @default.
- W2896470597 cites W2218179671 @default.
- W2896470597 cites W2290859018 @default.
- W2896470597 cites W2599245395 @default.
- W2896470597 cites W4211199921 @default.
- W2896470597 cites W82787745 @default.
- W2896470597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129490" @default.
- W2896470597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30210916" @default.
- W2896470597 hasPublicationYear "2018" @default.
- W2896470597 type Work @default.
- W2896470597 sameAs 2896470597 @default.
- W2896470597 citedByCount "3" @default.
- W2896470597 countsByYear W28964705972019 @default.
- W2896470597 countsByYear W28964705972021 @default.
- W2896470597 crossrefType "journal-article" @default.
- W2896470597 hasAuthorship W2896470597A5007409871 @default.
- W2896470597 hasAuthorship W2896470597A5011747309 @default.
- W2896470597 hasAuthorship W2896470597A5040623786 @default.
- W2896470597 hasAuthorship W2896470597A5048385740 @default.
- W2896470597 hasAuthorship W2896470597A5058673686 @default.
- W2896470597 hasAuthorship W2896470597A5059985657 @default.
- W2896470597 hasAuthorship W2896470597A5062384537 @default.
- W2896470597 hasAuthorship W2896470597A5078269576 @default.
- W2896470597 hasAuthorship W2896470597A5079618096 @default.
- W2896470597 hasConcept C104317684 @default.
- W2896470597 hasConcept C121608353 @default.
- W2896470597 hasConcept C126322002 @default.
- W2896470597 hasConcept C127561419 @default.
- W2896470597 hasConcept C149240914 @default.
- W2896470597 hasConcept C150903083 @default.
- W2896470597 hasConcept C199835354 @default.
- W2896470597 hasConcept C207001950 @default.
- W2896470597 hasConcept C2779013556 @default.
- W2896470597 hasConcept C2781018059 @default.
- W2896470597 hasConcept C29512474 @default.
- W2896470597 hasConcept C29537977 @default.
- W2896470597 hasConcept C502942594 @default.
- W2896470597 hasConcept C526805850 @default.
- W2896470597 hasConcept C54355233 @default.
- W2896470597 hasConcept C55493867 @default.
- W2896470597 hasConcept C555283112 @default.
- W2896470597 hasConcept C62112901 @default.
- W2896470597 hasConcept C71924100 @default.
- W2896470597 hasConcept C86339819 @default.
- W2896470597 hasConcept C86803240 @default.
- W2896470597 hasConceptScore W2896470597C104317684 @default.
- W2896470597 hasConceptScore W2896470597C121608353 @default.