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- W2896472260 abstract "Abstract Mesenchymal progenitor cells (MPCs) have been hypothesized as cells of origin for sarcomas, and c-Fos transcription factor has been showed to act as an oncogene in bone tumors. In this study, we show c-Fos is present in most sarcomas with chondral phenotype, while multiple other genes are related to c-Fos expression pattern. To further define the role of c-Fos in sarcomagenesis, we expressed it in primary human MPCs (hMPCs), immortalized hMPCs and transformed murine MPCs (mMPCs). In immortalized hMPCs, c-Fos expression generated morphological changes, reduced mobility capacity and impaired adipogenic- and osteogenic-differentiation potentials. Remarkably, immortalized hMPCs or mMPCs expressing c-Fos generated tumors harboring a chondrogenic phenotype and morphology. Thus, here we show that c-Fos protein has a key role in sarcomas and that c-Fos expression in immortalized MPCs yields cell transformation and chondrogenic tumor formation." @default.
- W2896472260 created "2018-10-26" @default.
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- W2896472260 date "2018-10-23" @default.
- W2896472260 modified "2023-10-18" @default.
- W2896472260 title "c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells" @default.
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- W2896472260 doi "https://doi.org/10.1038/s41598-018-33689-0" @default.
- W2896472260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199246" @default.
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