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- W2896472938 abstract "Background and study aim:: Many recent studies showed that chronic infection with hepatitis C virus (HCV) is associated with increased risk for B-cell non-Hodgkin's lymphoma (NHL). The aim of this study is to evaluate the frequency of HCV infection in a series of de novo B cell non Hodgkin's lymphoma (NHL) patients and to correlate virological findings with clinico-histological features.Patients and methods: 50 patients with B cell NHL diagnosed by histopathology and immunophenotyping were recruited from Tropical medicine department and Oncology unit affiliated to Internal medicine department, Zagazig University hospitals. Gender and age matched controls (N = 50) were volunteers selected from relatives of patients. Study participants were subjected to history taking, clinical examination, routine and specific laboratory tests. Anti-HCV antibody was determined by ELISA for all study participants. HCV RNA PCR was done for all cases and HCV antibody positive controls. Appropriate radiologic examinations were performed.Results :Frequency of HCV infections were statistically significantly higher in B cell NHL patients than in controls (p = 0.004). ALT levels were statistically significantly higher in HCV positive patients than in HCV positive controls (p < 0.001) and HCV negative patients but without statistically significant difference (p = 0.067). There was no statistically significant difference in histologic types, grades and stages of NHL between HCV positive patients and HCV negative patients. Cryoglobulinemia showed no significant difference between studied groups.Conclusion : HCV has a strong association with de novo B cell NHL, not complicating essential mixed cryoglobulinemia (EMC)." @default.
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- W2896472938 date "2013-03-20" @default.
- W2896472938 modified "2023-09-27" @default.
- W2896472938 title "Clinical and Epidemiologic Study of Hepatitis C Virus Genotype 4 Infection among Patients with B cell non Hodgkin's Lymphoma" @default.
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- W2896472938 doi "https://doi.org/10.21608/aeji.2013.17091" @default.
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