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- W2896473060 endingPage "40" @default.
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- W2896473060 abstract "Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome–host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions." @default.
- W2896473060 created "2018-10-26" @default.
- W2896473060 creator A5024640246 @default.
- W2896473060 creator A5044252504 @default.
- W2896473060 date "2018-10-15" @default.
- W2896473060 modified "2023-10-18" @default.
- W2896473060 title "The gut microbiome: Relationships with disease and opportunities for therapy" @default.
- W2896473060 cites W1536527549 @default.
- W2896473060 cites W1579566330 @default.
- W2896473060 cites W1583831774 @default.
- W2896473060 cites W1627839739 @default.
- W2896473060 cites W1689013859 @default.
- W2896473060 cites W1715339469 @default.
- W2896473060 cites W1825195823 @default.
- W2896473060 cites W1902150932 @default.
- W2896473060 cites W1922836559 @default.
- W2896473060 cites W1948774627 @default.
- W2896473060 cites W1968507220 @default.
- W2896473060 cites W1971415551 @default.
- W2896473060 cites W1971651068 @default.
- W2896473060 cites W1977761329 @default.
- W2896473060 cites W1978297432 @default.
- W2896473060 cites W1979012796 @default.
- W2896473060 cites W1981266729 @default.
- W2896473060 cites W1981296136 @default.
- W2896473060 cites W1986142882 @default.
- W2896473060 cites W1989478912 @default.
- W2896473060 cites W1989889539 @default.
- W2896473060 cites W1990726902 @default.
- W2896473060 cites W1991036879 @default.
- W2896473060 cites W1993399595 @default.
- W2896473060 cites W1993830991 @default.
- W2896473060 cites W1999906527 @default.
- W2896473060 cites W2000549941 @default.
- W2896473060 cites W2002703043 @default.
- W2896473060 cites W2004549986 @default.
- W2896473060 cites W2004690636 @default.
- W2896473060 cites W2007110604 @default.
- W2896473060 cites W2010748592 @default.
- W2896473060 cites W2016073955 @default.
- W2896473060 cites W2016586816 @default.
- W2896473060 cites W2019355614 @default.
- W2896473060 cites W2020847883 @default.
- W2896473060 cites W2023506796 @default.
- W2896473060 cites W2023615726 @default.
- W2896473060 cites W2026658658 @default.
- W2896473060 cites W2031284066 @default.
- W2896473060 cites W2033386838 @default.
- W2896473060 cites W2035612381 @default.
- W2896473060 cites W2041848357 @default.
- W2896473060 cites W2042394891 @default.
- W2896473060 cites W2044216294 @default.
- W2896473060 cites W2048469790 @default.
- W2896473060 cites W2048843644 @default.
- W2896473060 cites W2049448291 @default.
- W2896473060 cites W2055291719 @default.
- W2896473060 cites W2056515449 @default.
- W2896473060 cites W2057411492 @default.
- W2896473060 cites W2060130170 @default.
- W2896473060 cites W2060185417 @default.
- W2896473060 cites W2061671832 @default.
- W2896473060 cites W2061853512 @default.
- W2896473060 cites W2063856799 @default.
- W2896473060 cites W2066382988 @default.
- W2896473060 cites W2068162195 @default.
- W2896473060 cites W2068527256 @default.
- W2896473060 cites W2069354135 @default.
- W2896473060 cites W2071841602 @default.
- W2896473060 cites W2073714219 @default.
- W2896473060 cites W2077764881 @default.
- W2896473060 cites W2078599166 @default.
- W2896473060 cites W2079183971 @default.
- W2896473060 cites W2083501377 @default.
- W2896473060 cites W2084450750 @default.
- W2896473060 cites W2084891825 @default.
- W2896473060 cites W2085284704 @default.
- W2896473060 cites W2088170171 @default.
- W2896473060 cites W2089785364 @default.
- W2896473060 cites W2096500845 @default.
- W2896473060 cites W2097124003 @default.
- W2896473060 cites W2099456560 @default.
- W2896473060 cites W2107369528 @default.
- W2896473060 cites W2110389012 @default.
- W2896473060 cites W2113552312 @default.
- W2896473060 cites W2115015582 @default.
- W2896473060 cites W2115944543 @default.
- W2896473060 cites W2117029190 @default.
- W2896473060 cites W2120615647 @default.
- W2896473060 cites W2123463790 @default.
- W2896473060 cites W2123636816 @default.
- W2896473060 cites W2125784987 @default.
- W2896473060 cites W2125826054 @default.
- W2896473060 cites W2126147289 @default.
- W2896473060 cites W2126218947 @default.
- W2896473060 cites W2126657409 @default.
- W2896473060 cites W2127289457 @default.
- W2896473060 cites W2128610603 @default.
- W2896473060 cites W2136417551 @default.