FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896474780> ?p ?o ?g. }

• W2896474780 abstract "Allergen-specific immunotherapy (AIT) facilitates long-term resolution of allergic morbidity resulting in reduced drug use and increased refractoriness to new sensitization. AIT effectiveness has been demonstrated in seasonal and perennial allergies, and insect stings. However, data and studies in AIT relative to cockroach (CR) allergy are relatively scarce. In this study, mice allergic to American CR (Periplaneta americana) were treated with a liposome (L)-entrapped vaccine made of mouse Tregitope289-Per a 9 of the CR, Tregitope167-Per a 9, or Per a 9 alone - or placebo. Allergic mice that received an individual vaccine intranasally had reduced Th2 response, reduced lung inflammation, and reduced respiratory tissue remodeling. However, only L-Tregitope289-Per a 9 and L-Tregitope167-Per a 9 induced expression of immunosuppressive cytokine genes (IL-10, TGF-β, and IL-35 for L-Tregitope289-Per a 9, and IL-10 and TGF-β for L-Tregitope167-Per a 9) and increment of idoleamine-2,3-dioxygenase 1 (IDO1), indicating that these vaccines caused allergic disease suppression and reversal of respiratory tissue remodeling via generation of regulatory lymphocytes. Liposome entrapped-recombinant Per a 9 (L-Per a 9) did not cause upregulation of immunosuppressive cytokine genes and IDO1 increment; rather, L-Per a 9 induced high expression of IFN-γ in lungs of treated mice, which resulted in mitigation of allergic manifestations. This study provides compelling evidence that both liposome-entrapped vaccines made of single refined major allergen alone and single refined major allergen linked with Tregitopes are effective for reducing allergen-mediated respiratory tissue inflammation and remodeling, but through different mechanisms." @default.
• W2896474780 created "2018-10-26" @default.
• W2896474780 creator A5001937106 @default.
• W2896474780 creator A5003032964 @default.
• W2896474780 creator A5003915697 @default.
• W2896474780 creator A5017119198 @default.
• W2896474780 creator A5025954789 @default.
• W2896474780 creator A5051668237 @default.
• W2896474780 creator A5055049714 @default.
• W2896474780 creator A5060797915 @default.
• W2896474780 creator A5064247998 @default.
• W2896474780 creator A5079795992 @default.
• W2896474780 date "2018-10-19" @default.
• W2896474780 modified "2023-10-12" @default.
• W2896474780 title "Tregitope-linked Refined Allergen Vaccines for Immunotherapy in Cockroach Allergy" @default.
• W2896474780 cites W1217204668 @default.
• W2896474780 cites W121966211 @default.
• W2896474780 cites W1543659825 @default.
• W2896474780 cites W1658825848 @default.
• W2896474780 cites W1918392164 @default.
• W2896474780 cites W1919714885 @default.
• W2896474780 cites W1963785554 @default.
• W2896474780 cites W1967446605 @default.
• W2896474780 cites W1968245616 @default.
• W2896474780 cites W1977187462 @default.
• W2896474780 cites W1978846537 @default.
• W2896474780 cites W1981526660 @default.
• W2896474780 cites W1981776490 @default.
• W2896474780 cites W1992763270 @default.
• W2896474780 cites W1993775186 @default.
• W2896474780 cites W1998812407 @default.
• W2896474780 cites W2002892444 @default.
• W2896474780 cites W2006403631 @default.
• W2896474780 cites W2008232926 @default.
• W2896474780 cites W2010725648 @default.
• W2896474780 cites W2012836981 @default.
• W2896474780 cites W2014401119 @default.
• W2896474780 cites W2016427818 @default.
• W2896474780 cites W2017199648 @default.
• W2896474780 cites W2024505041 @default.
• W2896474780 cites W2027892478 @default.
• W2896474780 cites W2030477185 @default.
• W2896474780 cites W2032062642 @default.
• W2896474780 cites W2034047696 @default.
• W2896474780 cites W2038386610 @default.
• W2896474780 cites W2042949461 @default.
• W2896474780 cites W2045905087 @default.
• W2896474780 cites W2049586981 @default.
• W2896474780 cites W2052063445 @default.
• W2896474780 cites W2053762237 @default.
• W2896474780 cites W2054682292 @default.
• W2896474780 cites W2055797514 @default.
• W2896474780 cites W2057760381 @default.
• W2896474780 cites W2073393356 @default.
• W2896474780 cites W2075901113 @default.
• W2896474780 cites W2077490433 @default.
• W2896474780 cites W2080725704 @default.
• W2896474780 cites W2080905450 @default.
• W2896474780 cites W2084223350 @default.
• W2896474780 cites W2085530531 @default.
• W2896474780 cites W2087283042 @default.
• W2896474780 cites W2090644434 @default.
• W2896474780 cites W2093070846 @default.
• W2896474780 cites W2093901938 @default.
• W2896474780 cites W2105484520 @default.
• W2896474780 cites W2106190040 @default.
• W2896474780 cites W2106980654 @default.
• W2896474780 cites W2107074680 @default.
• W2896474780 cites W2119053287 @default.
• W2896474780 cites W2119453270 @default.
• W2896474780 cites W2121221609 @default.
• W2896474780 cites W2125311191 @default.
• W2896474780 cites W2126072190 @default.
• W2896474780 cites W2127092918 @default.
• W2896474780 cites W2131227262 @default.
• W2896474780 cites W2133805178 @default.
• W2896474780 cites W2134209372 @default.
• W2896474780 cites W2134768631 @default.
• W2896474780 cites W2141565645 @default.
• W2896474780 cites W2142155502 @default.
• W2896474780 cites W2142388937 @default.
• W2896474780 cites W2145897663 @default.
• W2896474780 cites W2146934919 @default.
• W2896474780 cites W2148226248 @default.
• W2896474780 cites W2151287143 @default.
• W2896474780 cites W2166174984 @default.
• W2896474780 cites W2168581900 @default.
• W2896474780 cites W2271602246 @default.
• W2896474780 cites W2295174991 @default.
• W2896474780 cites W2312648223 @default.
• W2896474780 cites W2399759921 @default.
• W2896474780 cites W2403648683 @default.
• W2896474780 cites W2409484306 @default.
• W2896474780 cites W2411778368 @default.
• W2896474780 cites W2422817612 @default.
• W2896474780 cites W2604425313 @default.
• W2896474780 cites W2606570431 @default.
• W2896474780 cites W2766804427 @default.
• W2896474780 cites W4245422493 @default.
• W2896474780 cites W50133594 @default.

• next