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• W2896475209 endingPage "2036" @default.
• W2896475209 startingPage "2031" @default.
• W2896475209 abstract "In the mammalian adipose organ cold exposure not only activates typical brown adipose tissue, but also induces browning, that is the formation of thermogenic multilocular adipocytes in white, or predominantly white, adipose depots such as subcutaneous fat. Unlike typical brown adipocytes, newly formed thermogenic adipocytes have been reported not to express the gene zinc finger of the cerebellum 1 (Zic1). Here, a time course approach enabled us to document a significant increase in Zic1 messenger RNA in inguinal subcutaneous fat from acutely (24 hr) cold-exposed mice, which was paralleled by an increase in multilocular and paucilocular uncoupling protein 1-positive adipocytes and in parenchymal noradrenergic innervation. This transient, depot-specific molecular signature was associated not to Zic1 promoter demethylation, but to chromatin remodeling through an H3K9me3 histone modification. These findings challenge the notion that Zic1 is exclusively expressed by typical brown adipocytes and suggest its involvement in brown adipocyte precursor differentiation and/or white-to-brown adipocyte transdifferentiation." @default.
• W2896475209 created "2018-10-26" @default.
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• W2896475209 date "2018-10-20" @default.
• W2896475209 modified "2023-10-03" @default.
• W2896475209 title "<i>Zic1</i> mRNA is transiently upregulated in subcutaneous fat of acutely cold‐exposed mice" @default.
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• W2896475209 doi "https://doi.org/10.1002/jcp.27301" @default.
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• W2896475209 hasPublicationYear "2018" @default.
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