FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896475267> ?p ?o ?g. }

• W2896475267 endingPage "88" @default.
• W2896475267 startingPage "88" @default.
• W2896475267 abstract "Adverse cardiac events are a major cause of late-stage drug development withdrawals. Improved in vitro systems for predicting cardiotoxicity are of great interest to prevent these events and to reduce the expenses involved in the introduction of cardiac drugs into the marketplace. Interdigitated electrodes (IDEs) affixed with a culture well provide a simple, suitable solution for in vitro analysis of cells because of their high sensitivity, ease of fabrication, and label-free, nondestructive analysis. Culturing human pluripotent stem cell differentiated cardiomyocytes onto these IDEs allows for the use of the IDE–cell combination in predictive toxicity assays. IDEs with smaller interdigitated distances allow for greater sensitivity, but typically require cleanroom fabrication. In this communication, we report the definition of a simple IDE geometry on a printed nanostructured substrate, demonstrate a Cellular Index (CI) increase from 0 to 7.7 for human cardiomyocytes, and a decrease in CI from 2.3 to 1 with increased concentration of the model drug, norepinephrine. The nanostructuring results in an increased sensitivity of our 1 mm pitch IDEs when compared to traditionally fabricated IDEs with a pitch of 10 μm (100 times larger electrode gap). The entire nanostructured IDE (nIDE) is fabricated and assembled in a rapid nanofabrication environment, thus allowing for iterative design changes and robust fabrication of devices." @default.
• W2896475267 created "2018-10-26" @default.
• W2896475267 creator A5001459584 @default.
• W2896475267 creator A5016556617 @default.
• W2896475267 creator A5038966372 @default.
• W2896475267 creator A5048529504 @default.
• W2896475267 creator A5053705461 @default.
• W2896475267 creator A5085900889 @default.
• W2896475267 date "2018-10-11" @default.
• W2896475267 modified "2023-09-25" @default.
• W2896475267 title "Rapid Nanofabrication of Nanostructured Interdigitated Electrodes (nIDEs) for Long-Term In Vitro Analysis of Human Induced Pluripotent Stem Cell Differentiated Cardiomyocytes" @default.
• W2896475267 cites W1966925143 @default.
• W2896475267 cites W1967597978 @default.
• W2896475267 cites W1983001316 @default.
• W2896475267 cites W1988493819 @default.
• W2896475267 cites W1990392669 @default.
• W2896475267 cites W1994454244 @default.
• W2896475267 cites W1996121786 @default.
• W2896475267 cites W2000154703 @default.
• W2896475267 cites W2025425435 @default.
• W2896475267 cites W2037574476 @default.
• W2896475267 cites W2049953591 @default.
• W2896475267 cites W2062074587 @default.
• W2896475267 cites W2072365644 @default.
• W2896475267 cites W2077239003 @default.
• W2896475267 cites W2081933497 @default.
• W2896475267 cites W2093393012 @default.
• W2896475267 cites W2114536422 @default.
• W2896475267 cites W2117640811 @default.
• W2896475267 cites W2126097423 @default.
• W2896475267 cites W2133312317 @default.
• W2896475267 cites W2138758415 @default.
• W2896475267 cites W2139658905 @default.
• W2896475267 cites W2273267066 @default.
• W2896475267 cites W2305997840 @default.
• W2896475267 cites W2315114363 @default.
• W2896475267 cites W2330586154 @default.
• W2896475267 cites W2607163305 @default.
• W2896475267 cites W2758506682 @default.
• W2896475267 cites W2771388151 @default.
• W2896475267 cites W2801715451 @default.
• W2896475267 doi "https://doi.org/10.3390/bios8040088" @default.
• W2896475267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6315475" @default.
• W2896475267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30314279" @default.
• W2896475267 hasPublicationYear "2018" @default.
• W2896475267 type Work @default.
• W2896475267 sameAs 2896475267 @default.
• W2896475267 citedByCount "9" @default.
• W2896475267 countsByYear W28964752672019 @default.
• W2896475267 countsByYear W28964752672020 @default.
• W2896475267 countsByYear W28964752672021 @default.
• W2896475267 countsByYear W28964752672023 @default.
• W2896475267 crossrefType "journal-article" @default.
• W2896475267 hasAuthorship W2896475267A5001459584 @default.
• W2896475267 hasAuthorship W2896475267A5016556617 @default.
• W2896475267 hasAuthorship W2896475267A5038966372 @default.
• W2896475267 hasAuthorship W2896475267A5048529504 @default.
• W2896475267 hasAuthorship W2896475267A5053705461 @default.
• W2896475267 hasAuthorship W2896475267A5085900889 @default.
• W2896475267 hasBestOaLocation W28964752671 @default.
• W2896475267 hasConcept C104317684 @default.
• W2896475267 hasConcept C107459253 @default.
• W2896475267 hasConcept C136229726 @default.
• W2896475267 hasConcept C136525101 @default.
• W2896475267 hasConcept C142724271 @default.
• W2896475267 hasConcept C145103041 @default.
• W2896475267 hasConcept C147789679 @default.
• W2896475267 hasConcept C162117346 @default.
• W2896475267 hasConcept C171250308 @default.
• W2896475267 hasConcept C17525397 @default.
• W2896475267 hasConcept C185592680 @default.
• W2896475267 hasConcept C18903297 @default.
• W2896475267 hasConcept C192562407 @default.
• W2896475267 hasConcept C204787440 @default.
• W2896475267 hasConcept C2777289219 @default.
• W2896475267 hasConcept C55493867 @default.
• W2896475267 hasConcept C71924100 @default.
• W2896475267 hasConcept C86803240 @default.
• W2896475267 hasConceptScore W2896475267C104317684 @default.
• W2896475267 hasConceptScore W2896475267C107459253 @default.
• W2896475267 hasConceptScore W2896475267C136229726 @default.
• W2896475267 hasConceptScore W2896475267C136525101 @default.
• W2896475267 hasConceptScore W2896475267C142724271 @default.
• W2896475267 hasConceptScore W2896475267C145103041 @default.
• W2896475267 hasConceptScore W2896475267C147789679 @default.
• W2896475267 hasConceptScore W2896475267C162117346 @default.
• W2896475267 hasConceptScore W2896475267C171250308 @default.
• W2896475267 hasConceptScore W2896475267C17525397 @default.
• W2896475267 hasConceptScore W2896475267C185592680 @default.
• W2896475267 hasConceptScore W2896475267C18903297 @default.
• W2896475267 hasConceptScore W2896475267C192562407 @default.
• W2896475267 hasConceptScore W2896475267C204787440 @default.
• W2896475267 hasConceptScore W2896475267C2777289219 @default.
• W2896475267 hasConceptScore W2896475267C55493867 @default.
• W2896475267 hasConceptScore W2896475267C71924100 @default.
• W2896475267 hasConceptScore W2896475267C86803240 @default.
• W2896475267 hasIssue "4" @default.
• W2896475267 hasLocation W28964752671 @default.

• next