Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896475918> ?p ?o ?g. }
- W2896475918 endingPage "428" @default.
- W2896475918 startingPage "418" @default.
- W2896475918 abstract "Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replication was markedly suppressed by the HDAC3 inhibitor at concentrations below 1 mmol/L, with no cellular toxicity. This was accompanied by upregulation of liver-expressed antimicrobial peptide 1(LEAP-1) and downregulation of apolipoprotein-A1 (Apo-A1), as determined by microarray and quantitative RT-PCR analyses. Moreover, HDAC3 was found to modulate the binding of CCAAT-enhancer-binding protein α (C/EBPα), hypoxia-inducible factor 1α (HIF1α), and signal transducer and activator of transcription 3 (STAT3) to the LEAP-1 promoter. HDAC3 inhibitor treatment also blocked HCV replication in a mouse model of HCV infection. These results indicate that epigenetic therapy with HDAC3 inhibitor may be a potential treatment for diseases associated with HCV infection such as HCC." @default.
- W2896475918 created "2018-10-26" @default.
- W2896475918 creator A5001727480 @default.
- W2896475918 creator A5015138375 @default.
- W2896475918 creator A5015192110 @default.
- W2896475918 creator A5023549221 @default.
- W2896475918 creator A5046225712 @default.
- W2896475918 creator A5058995598 @default.
- W2896475918 creator A5060122774 @default.
- W2896475918 creator A5083954692 @default.
- W2896475918 date "2018-10-01" @default.
- W2896475918 modified "2023-10-01" @default.
- W2896475918 title "Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression" @default.
- W2896475918 cites W1926812848 @default.
- W2896475918 cites W1965574722 @default.
- W2896475918 cites W1965874843 @default.
- W2896475918 cites W1968603331 @default.
- W2896475918 cites W1979101966 @default.
- W2896475918 cites W1995519633 @default.
- W2896475918 cites W1995866358 @default.
- W2896475918 cites W1999478182 @default.
- W2896475918 cites W2003460252 @default.
- W2896475918 cites W2006762935 @default.
- W2896475918 cites W2016406220 @default.
- W2896475918 cites W2017168923 @default.
- W2896475918 cites W2022687771 @default.
- W2896475918 cites W2026051181 @default.
- W2896475918 cites W2041175958 @default.
- W2896475918 cites W2046018527 @default.
- W2896475918 cites W2046878952 @default.
- W2896475918 cites W2059246129 @default.
- W2896475918 cites W2060833045 @default.
- W2896475918 cites W2072669480 @default.
- W2896475918 cites W2080760520 @default.
- W2896475918 cites W2081512087 @default.
- W2896475918 cites W2094748234 @default.
- W2896475918 cites W2114063466 @default.
- W2896475918 cites W2116374020 @default.
- W2896475918 cites W2122651892 @default.
- W2896475918 cites W2131344889 @default.
- W2896475918 cites W2131866222 @default.
- W2896475918 cites W2144347299 @default.
- W2896475918 cites W2153310042 @default.
- W2896475918 cites W2158794894 @default.
- W2896475918 cites W2161763646 @default.
- W2896475918 cites W2171931142 @default.
- W2896475918 cites W2174455830 @default.
- W2896475918 cites W2581198124 @default.
- W2896475918 cites W2601256291 @default.
- W2896475918 cites W2776863497 @default.
- W2896475918 cites W2789441109 @default.
- W2896475918 cites W2791118810 @default.
- W2896475918 cites W2792190643 @default.
- W2896475918 doi "https://doi.org/10.1007/s12250-018-0057-7" @default.
- W2896475918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6235766" @default.
- W2896475918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30328580" @default.
- W2896475918 hasPublicationYear "2018" @default.
- W2896475918 type Work @default.
- W2896475918 sameAs 2896475918 @default.
- W2896475918 citedByCount "21" @default.
- W2896475918 countsByYear W28964759182019 @default.
- W2896475918 countsByYear W28964759182020 @default.
- W2896475918 countsByYear W28964759182021 @default.
- W2896475918 countsByYear W28964759182022 @default.
- W2896475918 countsByYear W28964759182023 @default.
- W2896475918 crossrefType "journal-article" @default.
- W2896475918 hasAuthorship W2896475918A5001727480 @default.
- W2896475918 hasAuthorship W2896475918A5015138375 @default.
- W2896475918 hasAuthorship W2896475918A5015192110 @default.
- W2896475918 hasAuthorship W2896475918A5023549221 @default.
- W2896475918 hasAuthorship W2896475918A5046225712 @default.
- W2896475918 hasAuthorship W2896475918A5058995598 @default.
- W2896475918 hasAuthorship W2896475918A5060122774 @default.
- W2896475918 hasAuthorship W2896475918A5083954692 @default.
- W2896475918 hasBestOaLocation W28964759182 @default.
- W2896475918 hasConcept C104317684 @default.
- W2896475918 hasConcept C127561419 @default.
- W2896475918 hasConcept C13721689 @default.
- W2896475918 hasConcept C140704245 @default.
- W2896475918 hasConcept C153911025 @default.
- W2896475918 hasConcept C159047783 @default.
- W2896475918 hasConcept C171958077 @default.
- W2896475918 hasConcept C185592680 @default.
- W2896475918 hasConcept C190283241 @default.
- W2896475918 hasConcept C2522874641 @default.
- W2896475918 hasConcept C2776202225 @default.
- W2896475918 hasConcept C2776408679 @default.
- W2896475918 hasConcept C2778019345 @default.
- W2896475918 hasConcept C2778305200 @default.
- W2896475918 hasConcept C2778923194 @default.
- W2896475918 hasConcept C502942594 @default.
- W2896475918 hasConcept C55493867 @default.
- W2896475918 hasConcept C64927066 @default.
- W2896475918 hasConcept C86803240 @default.
- W2896475918 hasConceptScore W2896475918C104317684 @default.
- W2896475918 hasConceptScore W2896475918C127561419 @default.
- W2896475918 hasConceptScore W2896475918C13721689 @default.
- W2896475918 hasConceptScore W2896475918C140704245 @default.