Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896477433> ?p ?o ?g. }
- W2896477433 endingPage "511" @default.
- W2896477433 startingPage "511" @default.
- W2896477433 abstract "Background The pathogenesis of canine atopic dermatitis (cAD) is characterized immunologically by an imbalanced T‐cell response. Mechanisms of immune regulation in cAD have not yet been completely elucidated. Objectives To investigate peripheral blood T regulatory (Treg) cells and their associated cytokines ( TGF ‐β and IL ‐10) in an experimental model of cAD. Animals Eight beagle dogs that were initially naïve and subsequently sensitized to house dust mites ( HDM ). Methods and materials T regulatory cell phenotyping was performed by flow‐cytometric analysis on peripheral blood; serum cytokine levels were measured by ELISA , before sensitization and after challenge with HDM allergens. Additionally, clinical scores and allergen‐specific IgE were determined. Results After challenge of sensitized dogs to HDM allergen, a significant increase of Treg cells and simultaneous decrease in the serum TGF ‐β were observed. However, in most dogs, serum IL ‐10 values were below the detection limit. Treg cell proportions before sensitization were significantly negatively correlated with the HDM ‐specific IgE levels and clinical scores after induction of AD signs. Conclusion and clinical importance The results confirm that Treg responses are involved in the pathogenesis of an experimental model cAD. Further investigations are required to clarify the precise immune modulating function of canine Treg cells and their interplay with other immune cell types." @default.
- W2896477433 created "2018-10-26" @default.
- W2896477433 creator A5013232759 @default.
- W2896477433 creator A5048098004 @default.
- W2896477433 creator A5048673418 @default.
- W2896477433 creator A5088242513 @default.
- W2896477433 date "2018-10-14" @default.
- W2896477433 modified "2023-10-18" @default.
- W2896477433 title "Circulating CD4(+)CD25(+)Foxp3(+) T regulatory cell levels in an experimental model of canine atopic dermatitis" @default.
- W2896477433 cites W1546448788 @default.
- W2896477433 cites W1887030808 @default.
- W2896477433 cites W1977569994 @default.
- W2896477433 cites W1985497988 @default.
- W2896477433 cites W1998439798 @default.
- W2896477433 cites W2000593679 @default.
- W2896477433 cites W2001835698 @default.
- W2896477433 cites W2009645092 @default.
- W2896477433 cites W2011883392 @default.
- W2896477433 cites W2025255844 @default.
- W2896477433 cites W2027577699 @default.
- W2896477433 cites W2033279040 @default.
- W2896477433 cites W2040480773 @default.
- W2896477433 cites W2052086128 @default.
- W2896477433 cites W2060863615 @default.
- W2896477433 cites W2075875408 @default.
- W2896477433 cites W2082355065 @default.
- W2896477433 cites W2083212626 @default.
- W2896477433 cites W2084458714 @default.
- W2896477433 cites W2087228862 @default.
- W2896477433 cites W2091272671 @default.
- W2896477433 cites W2093238314 @default.
- W2896477433 cites W2100467573 @default.
- W2896477433 cites W2103185301 @default.
- W2896477433 cites W2108336583 @default.
- W2896477433 cites W2110947328 @default.
- W2896477433 cites W2115648838 @default.
- W2896477433 cites W2119236548 @default.
- W2896477433 cites W2146829832 @default.
- W2896477433 cites W2147770922 @default.
- W2896477433 cites W2148512586 @default.
- W2896477433 cites W2151677607 @default.
- W2896477433 cites W2193571202 @default.
- W2896477433 cites W2212724436 @default.
- W2896477433 cites W2315559373 @default.
- W2896477433 cites W2414030569 @default.
- W2896477433 cites W2473541542 @default.
- W2896477433 cites W2510623842 @default.
- W2896477433 cites W2551707517 @default.
- W2896477433 cites W2596082138 @default.
- W2896477433 cites W2604249065 @default.
- W2896477433 cites W2614583158 @default.
- W2896477433 cites W2732280095 @default.
- W2896477433 cites W2736343587 @default.
- W2896477433 cites W2776663677 @default.
- W2896477433 cites W560481452 @default.
- W2896477433 doi "https://doi.org/10.1111/vde.12693" @default.
- W2896477433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318823" @default.
- W2896477433 hasPublicationYear "2018" @default.
- W2896477433 type Work @default.
- W2896477433 sameAs 2896477433 @default.
- W2896477433 citedByCount "10" @default.
- W2896477433 countsByYear W28964774332020 @default.
- W2896477433 countsByYear W28964774332021 @default.
- W2896477433 countsByYear W28964774332022 @default.
- W2896477433 countsByYear W28964774332023 @default.
- W2896477433 crossrefType "journal-article" @default.
- W2896477433 hasAuthorship W2896477433A5013232759 @default.
- W2896477433 hasAuthorship W2896477433A5048098004 @default.
- W2896477433 hasAuthorship W2896477433A5048673418 @default.
- W2896477433 hasAuthorship W2896477433A5088242513 @default.
- W2896477433 hasConcept C126322002 @default.
- W2896477433 hasConcept C141105273 @default.
- W2896477433 hasConcept C159654299 @default.
- W2896477433 hasConcept C203014093 @default.
- W2896477433 hasConcept C207480886 @default.
- W2896477433 hasConcept C2776090121 @default.
- W2896477433 hasConcept C2776217527 @default.
- W2896477433 hasConcept C2776820430 @default.
- W2896477433 hasConcept C2777697326 @default.
- W2896477433 hasConcept C2778296632 @default.
- W2896477433 hasConcept C2778329239 @default.
- W2896477433 hasConcept C2778690821 @default.
- W2896477433 hasConcept C2779727006 @default.
- W2896477433 hasConcept C2780510475 @default.
- W2896477433 hasConcept C2780942790 @default.
- W2896477433 hasConcept C71924100 @default.
- W2896477433 hasConcept C79484868 @default.
- W2896477433 hasConcept C8891405 @default.
- W2896477433 hasConceptScore W2896477433C126322002 @default.
- W2896477433 hasConceptScore W2896477433C141105273 @default.
- W2896477433 hasConceptScore W2896477433C159654299 @default.
- W2896477433 hasConceptScore W2896477433C203014093 @default.
- W2896477433 hasConceptScore W2896477433C207480886 @default.
- W2896477433 hasConceptScore W2896477433C2776090121 @default.
- W2896477433 hasConceptScore W2896477433C2776217527 @default.
- W2896477433 hasConceptScore W2896477433C2776820430 @default.
- W2896477433 hasConceptScore W2896477433C2777697326 @default.
- W2896477433 hasConceptScore W2896477433C2778296632 @default.