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- W2896478512 abstract "Objective: To investigate the association between the polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and the formation of lower extremities deep venous thrombosis, and to evaluate the etiology of deep venous thrombosis.Methods: Polymorphisms of the 677th site C/T in MTHFR gene for 101 patients with lower extremities deep venous thrombosis (DVT group) and 120 healthy subjects (control group) were detected by polymerase chain reaction with sequence-specific primers. Genotype and allelic frequencies were compared between the two groups.Results: Genotype frequencies of CC, CT and TT in MTHFR C677 T were 41.58, 25.74 and 32.67% in DVT group, and 58.33, 23.33 and 18.33% in control group, respectively. There was a significant difference in TT genotype frequency between the two groups (P <0.05).Conclusion: The frequency of MTHFR 677TT genotype may be correlated with the morbility of DVT." @default.
- W2896478512 created "2018-10-26" @default.
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- W2896478512 date "2018-10-10" @default.
- W2896478512 modified "2023-10-17" @default.
- W2896478512 title "Relationship between genetic polymorphism of MTHFR C677T and lower extremities deep venous thrombosis" @default.
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- W2896478512 doi "https://doi.org/10.1080/10245332.2018.1526440" @default.
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