FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896480433> ?p ?o ?g. }

• W2896480433 abstract "Lung cancer is the leading cause of cancer-related deaths worldwide and in the United States. Despite recent advancements in treatment approaches, metastasis remains a major therapeutic challenge in lung cancer and explains the extremely poor prognosis. Epithelial to mesenchymal transition (EMT), a complex process of cellular reprogramming has become an attractive drug target because it plays a crucial role in the metastasis of non-small cell lung cancer (NSCLC). In the present study, we examined the effects of withaferin A (WFA), a plant-derived steroidal lactone on EMT in human NSCLC cell lines. First, we demonstrated that WFA displayed time- and concentration-dependent cytotoxicity on A549 and H1299 NSCLC cells. Then, cells were exposed to ≤ 0.5 µM WFA for ≤ 4 h to minimize cytotoxicity and determined its effects on EMT, cell adhesion, motility, migration, and invasion. EMT induction was performed by culturing cells in serum-free media containing TGFβ1 (5 ng/mL) and TNFα (25 ng/mL) for 48 h. We observed that pretreatment of cells with WFA inhibited cell adhesion, migration, and invasion of A549 and H1299 cells. Using western blot, immunofluorescence, and qRT-PCR analysis, we demonstrated that WFA suppressed TGFβ1 and TNFα-induced EMT in both cell lines. Mechanistically, WFA suppressed the phosphorylation and nuclear translocation of Smad2/3 and NF-κB in A549 and H1299 cells. Together, our study provides additional evidence demonstrating the inhibitory effects of WFA on EMT induction in NSCLC cells and further demonstrates the therapeutic potential of WFA against the metastasis in NSCLC." @default.
• W2896480433 created "2018-10-26" @default.
• W2896480433 creator A5000987242 @default.
• W2896480433 creator A5014387046 @default.
• W2896480433 creator A5034970510 @default.
• W2896480433 creator A5076591057 @default.
• W2896480433 date "2018-10-24" @default.
• W2896480433 modified "2023-10-14" @default.
• W2896480433 title "Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells" @default.
• W2896480433 cites W1510251233 @default.
• W2896480433 cites W1610269817 @default.
• W2896480433 cites W181662175 @default.
• W2896480433 cites W1862785918 @default.
• W2896480433 cites W1896519389 @default.
• W2896480433 cites W1922342700 @default.
• W2896480433 cites W1952952018 @default.
• W2896480433 cites W1963501822 @default.
• W2896480433 cites W1974721225 @default.
• W2896480433 cites W1983074899 @default.
• W2896480433 cites W1992362205 @default.
• W2896480433 cites W1993646281 @default.
• W2896480433 cites W1995853598 @default.
• W2896480433 cites W1996087175 @default.
• W2896480433 cites W2004937289 @default.
• W2896480433 cites W2015271346 @default.
• W2896480433 cites W2024880968 @default.
• W2896480433 cites W2025760032 @default.
• W2896480433 cites W2030200135 @default.
• W2896480433 cites W2032234787 @default.
• W2896480433 cites W2034752366 @default.
• W2896480433 cites W2048382257 @default.
• W2896480433 cites W2061548364 @default.
• W2896480433 cites W2075727690 @default.
• W2896480433 cites W2077173514 @default.
• W2896480433 cites W2089350420 @default.
• W2896480433 cites W2098969376 @default.
• W2896480433 cites W2108763926 @default.
• W2896480433 cites W2111226655 @default.
• W2896480433 cites W2114489635 @default.
• W2896480433 cites W2119630390 @default.
• W2896480433 cites W2124976492 @default.
• W2896480433 cites W2142426658 @default.
• W2896480433 cites W2154155929 @default.
• W2896480433 cites W2154432226 @default.
• W2896480433 cites W2154589460 @default.
• W2896480433 cites W2178935826 @default.
• W2896480433 cites W2235523093 @default.
• W2896480433 cites W2291906260 @default.
• W2896480433 cites W2324080174 @default.
• W2896480433 cites W2391015810 @default.
• W2896480433 cites W2437103229 @default.
• W2896480433 cites W2474397968 @default.
• W2896480433 cites W2499870864 @default.
• W2896480433 cites W2500192509 @default.
• W2896480433 cites W2519506672 @default.
• W2896480433 cites W2570618306 @default.
• W2896480433 cites W2587264845 @default.
• W2896480433 cites W2588236705 @default.
• W2896480433 cites W2606001457 @default.
• W2896480433 cites W2767217200 @default.
• W2896480433 cites W2773620963 @default.
• W2896480433 cites W2789727516 @default.
• W2896480433 cites W2799449613 @default.
• W2896480433 cites W2915992355 @default.
• W2896480433 cites W613093006 @default.
• W2896480433 cites W626431186 @default.
• W2896480433 doi "https://doi.org/10.1038/s41598-018-34018-1" @default.
• W2896480433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200817" @default.
• W2896480433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30356176" @default.
• W2896480433 hasPublicationYear "2018" @default.
• W2896480433 type Work @default.
• W2896480433 sameAs 2896480433 @default.
• W2896480433 citedByCount "39" @default.
• W2896480433 countsByYear W28964804332019 @default.
• W2896480433 countsByYear W28964804332020 @default.
• W2896480433 countsByYear W28964804332021 @default.
• W2896480433 countsByYear W28964804332022 @default.
• W2896480433 countsByYear W28964804332023 @default.
• W2896480433 crossrefType "journal-article" @default.
• W2896480433 hasAuthorship W2896480433A5000987242 @default.
• W2896480433 hasAuthorship W2896480433A5014387046 @default.
• W2896480433 hasAuthorship W2896480433A5034970510 @default.
• W2896480433 hasAuthorship W2896480433A5076591057 @default.
• W2896480433 hasBestOaLocation W28964804331 @default.
• W2896480433 hasConcept C109316439 @default.
• W2896480433 hasConcept C121608353 @default.
• W2896480433 hasConcept C137738243 @default.
• W2896480433 hasConcept C142724271 @default.
• W2896480433 hasConcept C1491633281 @default.
• W2896480433 hasConcept C185592680 @default.
• W2896480433 hasConcept C202751555 @default.
• W2896480433 hasConcept C204787440 @default.
• W2896480433 hasConcept C2776256026 @default.
• W2896480433 hasConcept C2776598214 @default.
• W2896480433 hasConcept C2779013556 @default.
• W2896480433 hasConcept C2780069950 @default.
• W2896480433 hasConcept C502942594 @default.
• W2896480433 hasConcept C54355233 @default.
• W2896480433 hasConcept C55493867 @default.
• W2896480433 hasConcept C71924100 @default.

• next