Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896485687> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2896485687 endingPage "464" @default.
- W2896485687 startingPage "454" @default.
- W2896485687 abstract "Rationale: Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge.Objectives: Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS therapy over 7 days can identify nonadherence to ICS treatment in difficult-to-control asthma. We examined the feasibility and utility of FeNO suppression testing in routine clinical care within UK severe asthma centers using remote monitoring technologies.Methods: A web-based interface with integrated remote monitoring technology was developed to deliver FeNO suppression testing. We examined the utility of FeNO suppression testing to demonstrate ICS responsiveness and clinical benefit on electronically monitored treatment with standard high-dose ICS and long-acting β2-agonist treatment.Measurements and Main Results: Clinical response was assessed using the Asthma Control Questionnaire-5, spirometry, and biomarker measurements (FeNO and peripheral blood eosinophil count). Of 250 subjects, 201 completed the test with 130 positive suppression tests. Compared with a negative suppression test, a positive test identified a FeNO-low population when adherent with ICS/long-acting β2-agonist (median, 26 ppb [interquartile range, 16–36 ppb] vs. 43 ppb [interquartile range, 38–73 ppb]) with significantly greater FEV1% (mean, 88.2 ± 16.4 vs. 74.1 ± 20.9; P < 0.01). Asthma Control Questionnaire-5 improved significantly in both groups (positive test: mean difference, −1.2; 95% confidence interval, −0.9 to −1.5; negative test: mean difference, −0.9; 95% confidence interval, −0.4 to −1.3).Conclusions: Remote FeNO suppression testing is an effective means of identifying nonadherence to ICS in subjects with difficult-to-control asthma and the substantial population of subjects who derive important clinical benefits from optimized ICS/long-acting β2-agonist treatment." @default.
- W2896485687 created "2018-10-26" @default.
- W2896485687 creator A5003209014 @default.
- W2896485687 creator A5003633153 @default.
- W2896485687 creator A5011606845 @default.
- W2896485687 creator A5016521386 @default.
- W2896485687 creator A5031512480 @default.
- W2896485687 creator A5035503350 @default.
- W2896485687 creator A5043495928 @default.
- W2896485687 creator A5076371917 @default.
- W2896485687 creator A5078489750 @default.
- W2896485687 date "2019-02-15" @default.
- W2896485687 modified "2023-10-16" @default.
- W2896485687 title "Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma" @default.
- W2896485687 cites W1977264840 @default.
- W2896485687 cites W1997331999 @default.
- W2896485687 cites W2013695939 @default.
- W2896485687 cites W2029834141 @default.
- W2896485687 cites W2054318148 @default.
- W2896485687 cites W2062301054 @default.
- W2896485687 cites W2069330998 @default.
- W2896485687 cites W2069695034 @default.
- W2896485687 cites W2075070881 @default.
- W2896485687 cites W2094189191 @default.
- W2896485687 cites W2100578775 @default.
- W2896485687 cites W2110143000 @default.
- W2896485687 cites W2137275746 @default.
- W2896485687 cites W2141343329 @default.
- W2896485687 cites W2151520766 @default.
- W2896485687 cites W2158490560 @default.
- W2896485687 cites W2272515352 @default.
- W2896485687 cites W2339210469 @default.
- W2896485687 cites W2569969039 @default.
- W2896485687 cites W2782372894 @default.
- W2896485687 cites W2884905216 @default.
- W2896485687 doi "https://doi.org/10.1164/rccm.201806-1182oc" @default.
- W2896485687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30339770" @default.
- W2896485687 hasPublicationYear "2019" @default.
- W2896485687 type Work @default.
- W2896485687 sameAs 2896485687 @default.
- W2896485687 citedByCount "104" @default.
- W2896485687 countsByYear W28964856872019 @default.
- W2896485687 countsByYear W28964856872020 @default.
- W2896485687 countsByYear W28964856872021 @default.
- W2896485687 countsByYear W28964856872022 @default.
- W2896485687 countsByYear W28964856872023 @default.
- W2896485687 crossrefType "journal-article" @default.
- W2896485687 hasAuthorship W2896485687A5003209014 @default.
- W2896485687 hasAuthorship W2896485687A5003633153 @default.
- W2896485687 hasAuthorship W2896485687A5011606845 @default.
- W2896485687 hasAuthorship W2896485687A5016521386 @default.
- W2896485687 hasAuthorship W2896485687A5031512480 @default.
- W2896485687 hasAuthorship W2896485687A5035503350 @default.
- W2896485687 hasAuthorship W2896485687A5043495928 @default.
- W2896485687 hasAuthorship W2896485687A5076371917 @default.
- W2896485687 hasAuthorship W2896485687A5078489750 @default.
- W2896485687 hasBestOaLocation W28964856872 @default.
- W2896485687 hasConcept C119060515 @default.
- W2896485687 hasConcept C126322002 @default.
- W2896485687 hasConcept C2776042228 @default.
- W2896485687 hasConcept C2780333948 @default.
- W2896485687 hasConcept C2781142857 @default.
- W2896485687 hasConcept C44249647 @default.
- W2896485687 hasConcept C71924100 @default.
- W2896485687 hasConceptScore W2896485687C119060515 @default.
- W2896485687 hasConceptScore W2896485687C126322002 @default.
- W2896485687 hasConceptScore W2896485687C2776042228 @default.
- W2896485687 hasConceptScore W2896485687C2780333948 @default.
- W2896485687 hasConceptScore W2896485687C2781142857 @default.
- W2896485687 hasConceptScore W2896485687C44249647 @default.
- W2896485687 hasConceptScore W2896485687C71924100 @default.
- W2896485687 hasIssue "4" @default.
- W2896485687 hasLocation W28964856871 @default.
- W2896485687 hasLocation W28964856872 @default.
- W2896485687 hasLocation W28964856873 @default.
- W2896485687 hasLocation W28964856874 @default.
- W2896485687 hasLocation W28964856875 @default.
- W2896485687 hasLocation W28964856876 @default.
- W2896485687 hasLocation W28964856877 @default.
- W2896485687 hasOpenAccess W2896485687 @default.
- W2896485687 hasPrimaryLocation W28964856871 @default.
- W2896485687 hasRelatedWork W1925753595 @default.
- W2896485687 hasRelatedWork W1959229688 @default.
- W2896485687 hasRelatedWork W2082910604 @default.
- W2896485687 hasRelatedWork W2091055700 @default.
- W2896485687 hasRelatedWork W2094572771 @default.
- W2896485687 hasRelatedWork W2105996441 @default.
- W2896485687 hasRelatedWork W2145180660 @default.
- W2896485687 hasRelatedWork W2152677112 @default.
- W2896485687 hasRelatedWork W2293317142 @default.
- W2896485687 hasRelatedWork W2468456742 @default.
- W2896485687 hasVolume "199" @default.
- W2896485687 isParatext "false" @default.
- W2896485687 isRetracted "false" @default.
- W2896485687 magId "2896485687" @default.
- W2896485687 workType "article" @default.