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• W2896486358 abstract "For the opportunistic pathogen Acinetobacter baumannii, desiccation tolerance is thought to contribute significantly to the persistence of these bacteria in the healthcare environment. We investigated the ability of A. baumannii to survive rapid drying, and found that some strains exhibited a profoundly desiccation-resistant phenotype, characterized by the ability of a large proportion of cells to survive on a dry surface for an extended period of time. However, this phenotype was only displayed during the stationary phase of growth. Most interestingly, we found that drying resistance could be lost after extended cultivation in liquid medium. Genome sequencing of isolates that became drying-sensitive identified mutations in bfmR, which encodes a two-component response regulator that is important for A. baumannii virulence. Additionally, BfmR was necessary for the expression of stress-related proteins during stationary phase, and one of these, KatE, was important for long-term drying survival. These results suggested that BfmR may control stress responses, and we demonstrated that the ΔbfmR mutant was more sensitive to hydrogen peroxide, nutrient starvation, and increased osmolarity. We also found that cross-protection against drying could be stimulated by either starvation, which required BfmR, or increased osmolarity. These results imply that BfmR plays a role in controlling stress responses in A. baumannii which help protect cells during desiccation, and they provide a regulatory link between this organism’s ability to persist in the environment and pathogenicity." @default.
• W2896486358 created "2018-10-26" @default.
• W2896486358 creator A5015157343 @default.
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• W2896486358 date "2018-10-11" @default.
• W2896486358 modified "2023-10-03" @default.
• W2896486358 title "Desiccation tolerance in Acinetobacter baumannii is mediated by the two-component response regulator BfmR" @default.
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• W2896486358 doi "https://doi.org/10.1371/journal.pone.0205638" @default.
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• W2896486358 hasPublicationYear "2018" @default.
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