Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896491549> ?p ?o ?g. }
- W2896491549 abstract "Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma as well as degeneration of axons and dendrites by a process associated with Ca2+ increase and mitochondrial dysfunction. Importantly, degeneration of axons initiated by diverse stimuli, including excitotoxicity, has been proposed as an important pathological event leading to functional impairment in neurodegenerative conditions. Here, we demonstrate that excitotoxicity-induced axonal degeneration proceeds by a mechanism dependent on the necroptotic kinases RIPK1 and RIPK3, and the necroptotic mediator MLKL. Inhibition of RIPK1, RIPK3 or MLKL prevents key steps in the axonal degeneration cascade, including mitochondrial depolarization, the opening of the permeability transition pore and Ca2+ dysregulation in the axon. Interestingly, the same excitotoxic stimuli lead to apoptosis in the cell soma, demonstrating the co-activation of two independent degenerative mechanisms in different compartments of the same cell. The identification of necroptosis as a key mechanism of axonal degeneration after excitotoxicity is an important initial step in the development of novel therapeutic strategies for nervous system disorders." @default.
- W2896491549 created "2018-10-26" @default.
- W2896491549 creator A5016794984 @default.
- W2896491549 creator A5031468759 @default.
- W2896491549 creator A5033289727 @default.
- W2896491549 creator A5060265654 @default.
- W2896491549 creator A5073120332 @default.
- W2896491549 creator A5080217947 @default.
- W2896491549 date "2018-01-01" @default.
- W2896491549 modified "2023-10-01" @default.
- W2896491549 title "Axonal degeneration induced by glutamate-excitotoxicity is mediated by necroptosis" @default.
- W2896491549 cites W1165140024 @default.
- W2896491549 cites W1537667127 @default.
- W2896491549 cites W1572664742 @default.
- W2896491549 cites W1966977448 @default.
- W2896491549 cites W1971324155 @default.
- W2896491549 cites W1976805974 @default.
- W2896491549 cites W1977949839 @default.
- W2896491549 cites W1983078635 @default.
- W2896491549 cites W1984096229 @default.
- W2896491549 cites W1985988728 @default.
- W2896491549 cites W1987046506 @default.
- W2896491549 cites W1995464318 @default.
- W2896491549 cites W1996568613 @default.
- W2896491549 cites W1999150386 @default.
- W2896491549 cites W2001611645 @default.
- W2896491549 cites W2003682409 @default.
- W2896491549 cites W2006273251 @default.
- W2896491549 cites W2024035512 @default.
- W2896491549 cites W2026874869 @default.
- W2896491549 cites W2027222718 @default.
- W2896491549 cites W2027371168 @default.
- W2896491549 cites W2032331465 @default.
- W2896491549 cites W2040891140 @default.
- W2896491549 cites W2042776153 @default.
- W2896491549 cites W2043413246 @default.
- W2896491549 cites W2044190420 @default.
- W2896491549 cites W2061463538 @default.
- W2896491549 cites W2061987394 @default.
- W2896491549 cites W2073774899 @default.
- W2896491549 cites W2080023466 @default.
- W2896491549 cites W2081791223 @default.
- W2896491549 cites W2082879602 @default.
- W2896491549 cites W2087688816 @default.
- W2896491549 cites W2091263717 @default.
- W2896491549 cites W2091363184 @default.
- W2896491549 cites W2104586441 @default.
- W2896491549 cites W2114546997 @default.
- W2896491549 cites W2118145481 @default.
- W2896491549 cites W2118183647 @default.
- W2896491549 cites W2118621467 @default.
- W2896491549 cites W2131357993 @default.
- W2896491549 cites W2139552156 @default.
- W2896491549 cites W2147490281 @default.
- W2896491549 cites W2151431455 @default.
- W2896491549 cites W2155939426 @default.
- W2896491549 cites W2159190959 @default.
- W2896491549 cites W2160651627 @default.
- W2896491549 cites W2161240378 @default.
- W2896491549 cites W2162938016 @default.
- W2896491549 cites W2197934318 @default.
- W2896491549 cites W2311228285 @default.
- W2896491549 cites W2472282050 @default.
- W2896491549 cites W2500850723 @default.
- W2896491549 cites W2729130068 @default.
- W2896491549 cites W2739182934 @default.
- W2896491549 cites W2740768704 @default.
- W2896491549 cites W2771762388 @default.
- W2896491549 cites W4361960923 @default.
- W2896491549 doi "https://doi.org/10.1242/jcs.214684" @default.
- W2896491549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30333135" @default.
- W2896491549 hasPublicationYear "2018" @default.
- W2896491549 type Work @default.
- W2896491549 sameAs 2896491549 @default.
- W2896491549 citedByCount "49" @default.
- W2896491549 countsByYear W28964915492019 @default.
- W2896491549 countsByYear W28964915492020 @default.
- W2896491549 countsByYear W28964915492021 @default.
- W2896491549 countsByYear W28964915492022 @default.
- W2896491549 countsByYear W28964915492023 @default.
- W2896491549 crossrefType "journal-article" @default.
- W2896491549 hasAuthorship W2896491549A5016794984 @default.
- W2896491549 hasAuthorship W2896491549A5031468759 @default.
- W2896491549 hasAuthorship W2896491549A5033289727 @default.
- W2896491549 hasAuthorship W2896491549A5060265654 @default.
- W2896491549 hasAuthorship W2896491549A5073120332 @default.
- W2896491549 hasAuthorship W2896491549A5080217947 @default.
- W2896491549 hasBestOaLocation W28964915491 @default.
- W2896491549 hasConcept C169760540 @default.
- W2896491549 hasConcept C170493617 @default.
- W2896491549 hasConcept C190283241 @default.
- W2896491549 hasConcept C25498285 @default.
- W2896491549 hasConcept C2781012912 @default.
- W2896491549 hasConcept C31573885 @default.
- W2896491549 hasConcept C55493867 @default.
- W2896491549 hasConcept C61174792 @default.
- W2896491549 hasConcept C86803240 @default.
- W2896491549 hasConcept C94030615 @default.
- W2896491549 hasConcept C95444343 @default.
- W2896491549 hasConceptScore W2896491549C169760540 @default.