Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896492396> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2896492396 endingPage "247" @default.
- W2896492396 startingPage "244" @default.
- W2896492396 abstract "Sepsis affects microcirculation and tissue perfusion leading to tissue hypoxia and multiple organ dysfunction. Red blood cells (RBCs; erythrocytes) are typically biconcave in shape, transport hemoglobin-bound oxygen and are reversibly deformable facilitating trafficking through capillaries. Decreased deformability of RBCs adversely affects tissue oxygenation. The purpose of this project was to determine RBC deformability in a murine model of polymicrobial sepsis by a method that utilizes laser diffraction and microfluidics, and to identify the causative factors in the plasma that may contribute to loss in RBC deformability. Blood samples from mice subjected to cecal ligation and puncture (CLP) model of sepsis were used. RBC deformability was tested using Rheoscan-AnD 300 under shear stress range of 0–20 Pascal (Pa) that depicts the common rheological behavior of RBCs flowing through blood vessels ranging from major vessels to capillaries. Normal RBCs were treated with plasma-derived extracellular vesicles (EVs) and their effect on RBC deformability was also tested. The experiments demonstrated a significant decrease in RBC deformability following sepsis. RBC deformability recovered in sham-operated animals by the third day, whereas animals with sepsis continued to show decreased levels of deformability. EVs isolated from the plasma of animals from the sepsis group significantly decreased deformability of RBCs ex vivo. Analysis of miRNA cargo in EVs showed distinct molecular profiles for sham-operated and sepsis-induced mice. In summary, sepsis induced a decrease in RBC deformability and the acquired rigidity may have adverse effect on microcirculation, tissue perfusion, and organ function." @default.
- W2896492396 created "2018-10-26" @default.
- W2896492396 creator A5015971774 @default.
- W2896492396 creator A5021930672 @default.
- W2896492396 creator A5022376747 @default.
- W2896492396 creator A5036299992 @default.
- W2896492396 creator A5040246143 @default.
- W2896492396 creator A5045576336 @default.
- W2896492396 creator A5049233669 @default.
- W2896492396 creator A5065259032 @default.
- W2896492396 date "2018-12-01" @default.
- W2896492396 modified "2023-09-27" @default.
- W2896492396 title "Effect of plasma-derived extracellular vesicles on erythrocyte deformability in polymicrobial sepsis" @default.
- W2896492396 cites W1638199269 @default.
- W2896492396 cites W1825470131 @default.
- W2896492396 cites W1830131903 @default.
- W2896492396 cites W1967680980 @default.
- W2896492396 cites W1991316122 @default.
- W2896492396 cites W2140775205 @default.
- W2896492396 cites W2253598100 @default.
- W2896492396 cites W2282181907 @default.
- W2896492396 cites W2515956763 @default.
- W2896492396 cites W2574716747 @default.
- W2896492396 cites W2613036842 @default.
- W2896492396 cites W2753581698 @default.
- W2896492396 cites W2760372910 @default.
- W2896492396 cites W2761369473 @default.
- W2896492396 cites W2766905006 @default.
- W2896492396 cites W2797673761 @default.
- W2896492396 doi "https://doi.org/10.1016/j.intimp.2018.10.011" @default.
- W2896492396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30340103" @default.
- W2896492396 hasPublicationYear "2018" @default.
- W2896492396 type Work @default.
- W2896492396 sameAs 2896492396 @default.
- W2896492396 citedByCount "14" @default.
- W2896492396 countsByYear W28964923962019 @default.
- W2896492396 countsByYear W28964923962020 @default.
- W2896492396 countsByYear W28964923962021 @default.
- W2896492396 countsByYear W28964923962022 @default.
- W2896492396 countsByYear W28964923962023 @default.
- W2896492396 crossrefType "journal-article" @default.
- W2896492396 hasAuthorship W2896492396A5015971774 @default.
- W2896492396 hasAuthorship W2896492396A5021930672 @default.
- W2896492396 hasAuthorship W2896492396A5022376747 @default.
- W2896492396 hasAuthorship W2896492396A5036299992 @default.
- W2896492396 hasAuthorship W2896492396A5040246143 @default.
- W2896492396 hasAuthorship W2896492396A5045576336 @default.
- W2896492396 hasAuthorship W2896492396A5049233669 @default.
- W2896492396 hasAuthorship W2896492396A5065259032 @default.
- W2896492396 hasConcept C126322002 @default.
- W2896492396 hasConcept C12722491 @default.
- W2896492396 hasConcept C142724271 @default.
- W2896492396 hasConcept C146957229 @default.
- W2896492396 hasConcept C185592680 @default.
- W2896492396 hasConcept C203014093 @default.
- W2896492396 hasConcept C2776185378 @default.
- W2896492396 hasConcept C2776557347 @default.
- W2896492396 hasConcept C2778384902 @default.
- W2896492396 hasConcept C71924100 @default.
- W2896492396 hasConcept C86803240 @default.
- W2896492396 hasConceptScore W2896492396C126322002 @default.
- W2896492396 hasConceptScore W2896492396C12722491 @default.
- W2896492396 hasConceptScore W2896492396C142724271 @default.
- W2896492396 hasConceptScore W2896492396C146957229 @default.
- W2896492396 hasConceptScore W2896492396C185592680 @default.
- W2896492396 hasConceptScore W2896492396C203014093 @default.
- W2896492396 hasConceptScore W2896492396C2776185378 @default.
- W2896492396 hasConceptScore W2896492396C2776557347 @default.
- W2896492396 hasConceptScore W2896492396C2778384902 @default.
- W2896492396 hasConceptScore W2896492396C71924100 @default.
- W2896492396 hasConceptScore W2896492396C86803240 @default.
- W2896492396 hasFunder F4320313241 @default.
- W2896492396 hasLocation W28964923961 @default.
- W2896492396 hasLocation W28964923962 @default.
- W2896492396 hasOpenAccess W2896492396 @default.
- W2896492396 hasPrimaryLocation W28964923961 @default.
- W2896492396 hasRelatedWork W1731661205 @default.
- W2896492396 hasRelatedWork W1963685809 @default.
- W2896492396 hasRelatedWork W1980577456 @default.
- W2896492396 hasRelatedWork W2058293803 @default.
- W2896492396 hasRelatedWork W2151572463 @default.
- W2896492396 hasRelatedWork W2317938909 @default.
- W2896492396 hasRelatedWork W2418045248 @default.
- W2896492396 hasRelatedWork W2593480838 @default.
- W2896492396 hasRelatedWork W2896492396 @default.
- W2896492396 hasRelatedWork W45554366 @default.
- W2896492396 hasVolume "65" @default.
- W2896492396 isParatext "false" @default.
- W2896492396 isRetracted "false" @default.
- W2896492396 magId "2896492396" @default.
- W2896492396 workType "article" @default.