Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896493799> ?p ?o ?g. }
- W2896493799 endingPage "15" @default.
- W2896493799 startingPage "1" @default.
- W2896493799 abstract "Seasonal H3N2 influenza viruses are recognized as major epidemic viruses, exhibiting complex seasonal patterns in regions with temperate climates. To investigate the influence of viral evolution and mutations on the seasonality of influenza, we performed a genome-wide analysis of samples collected from 62 influenza A/H3N2-infected patients in Shanghai during 2016-2017. Phylogenetic analysis of all eight segments of the influenza A virus revealed that there were two epidemic influenza virus strains circulating in the 2016-2017 winter season (2016-2017win) and 2017 summer season (2017sum). Replication of the two epidemic viral strains at different temperatures (33, 35, 37, and 39 °C) was measured, and the correlation of the mutations in the two epidemic viral strains with temperature sensitivity and viral replication was analyzed. Analysis of the replication kinetics showed that replication of the 2016-2017win strains was significantly restricted at 39 °C compared with that of the 2017sum strains. A polymerase activity assay and mutational analysis demonstrated that the PA I668V mutation of the 2016-2017win viruses suppressed polymerase activity in vitro at high temperatures. Taken together, these data suggest that the I668V mutation in the PA subunit of the 2016-2017win strains may confer temperature sensitivity and attenuate viral replication and polymerase activity; meanwhile, the 2017sum strains maintained virulence at high temperatures. These findings highlight the importance of certain mutations in viral adaptation and persistence in subsequent seasons." @default.
- W2896493799 created "2018-10-26" @default.
- W2896493799 creator A5009492388 @default.
- W2896493799 creator A5035441171 @default.
- W2896493799 creator A5038394541 @default.
- W2896493799 creator A5058298924 @default.
- W2896493799 creator A5065837492 @default.
- W2896493799 creator A5068779570 @default.
- W2896493799 creator A5088009780 @default.
- W2896493799 date "2018-10-23" @default.
- W2896493799 modified "2023-10-02" @default.
- W2896493799 title "Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit" @default.
- W2896493799 cites W1667924947 @default.
- W2896493799 cites W1827177868 @default.
- W2896493799 cites W1951851047 @default.
- W2896493799 cites W1966521561 @default.
- W2896493799 cites W1971428926 @default.
- W2896493799 cites W1990180184 @default.
- W2896493799 cites W1990322430 @default.
- W2896493799 cites W1991678148 @default.
- W2896493799 cites W1993047642 @default.
- W2896493799 cites W1995565820 @default.
- W2896493799 cites W2001454912 @default.
- W2896493799 cites W2009305992 @default.
- W2896493799 cites W2010230226 @default.
- W2896493799 cites W2018549259 @default.
- W2896493799 cites W2038210037 @default.
- W2896493799 cites W2051154138 @default.
- W2896493799 cites W2056036445 @default.
- W2896493799 cites W2057408069 @default.
- W2896493799 cites W2068826744 @default.
- W2896493799 cites W2090027320 @default.
- W2896493799 cites W2092028051 @default.
- W2896493799 cites W2099533162 @default.
- W2896493799 cites W2120769731 @default.
- W2896493799 cites W2127899060 @default.
- W2896493799 cites W2128718394 @default.
- W2896493799 cites W2132081049 @default.
- W2896493799 cites W2145774243 @default.
- W2896493799 cites W2147460421 @default.
- W2896493799 cites W2152976799 @default.
- W2896493799 cites W2153184851 @default.
- W2896493799 cites W2154499546 @default.
- W2896493799 cites W2158783068 @default.
- W2896493799 cites W2159042976 @default.
- W2896493799 cites W2215831586 @default.
- W2896493799 cites W2258000915 @default.
- W2896493799 cites W2542920945 @default.
- W2896493799 cites W3160971351 @default.
- W2896493799 doi "https://doi.org/10.1038/s41426-018-0172-4" @default.
- W2896493799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199244" @default.
- W2896493799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30353004" @default.
- W2896493799 hasPublicationYear "2018" @default.
- W2896493799 type Work @default.
- W2896493799 sameAs 2896493799 @default.
- W2896493799 citedByCount "6" @default.
- W2896493799 countsByYear W28964937992020 @default.
- W2896493799 countsByYear W28964937992022 @default.
- W2896493799 countsByYear W28964937992023 @default.
- W2896493799 crossrefType "journal-article" @default.
- W2896493799 hasAuthorship W2896493799A5009492388 @default.
- W2896493799 hasAuthorship W2896493799A5035441171 @default.
- W2896493799 hasAuthorship W2896493799A5038394541 @default.
- W2896493799 hasAuthorship W2896493799A5058298924 @default.
- W2896493799 hasAuthorship W2896493799A5065837492 @default.
- W2896493799 hasAuthorship W2896493799A5068779570 @default.
- W2896493799 hasAuthorship W2896493799A5088009780 @default.
- W2896493799 hasBestOaLocation W28964937991 @default.
- W2896493799 hasConcept C104317684 @default.
- W2896493799 hasConcept C140704245 @default.
- W2896493799 hasConcept C141231307 @default.
- W2896493799 hasConcept C159047783 @default.
- W2896493799 hasConcept C193252679 @default.
- W2896493799 hasConcept C2522874641 @default.
- W2896493799 hasConcept C2777546802 @default.
- W2896493799 hasConcept C501734568 @default.
- W2896493799 hasConcept C54355233 @default.
- W2896493799 hasConcept C60987743 @default.
- W2896493799 hasConcept C82381507 @default.
- W2896493799 hasConcept C86803240 @default.
- W2896493799 hasConcept C8769409 @default.
- W2896493799 hasConceptScore W2896493799C104317684 @default.
- W2896493799 hasConceptScore W2896493799C140704245 @default.
- W2896493799 hasConceptScore W2896493799C141231307 @default.
- W2896493799 hasConceptScore W2896493799C159047783 @default.
- W2896493799 hasConceptScore W2896493799C193252679 @default.
- W2896493799 hasConceptScore W2896493799C2522874641 @default.
- W2896493799 hasConceptScore W2896493799C2777546802 @default.
- W2896493799 hasConceptScore W2896493799C501734568 @default.
- W2896493799 hasConceptScore W2896493799C54355233 @default.
- W2896493799 hasConceptScore W2896493799C60987743 @default.
- W2896493799 hasConceptScore W2896493799C82381507 @default.
- W2896493799 hasConceptScore W2896493799C86803240 @default.
- W2896493799 hasConceptScore W2896493799C8769409 @default.
- W2896493799 hasIssue "1" @default.
- W2896493799 hasLocation W28964937991 @default.
- W2896493799 hasLocation W28964937992 @default.
- W2896493799 hasLocation W28964937993 @default.