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- W2896495819 abstract "Objective: We sought to identify any potential association between history of intracranial hemorrhage (ICH) and mortality in patients treated with intravenous tissue plasminogen activator (IV-tPA) for acute ischemic stroke (AIS). Background: History of ICH is no longer a contraindication for IV-tPA in AIS. Data on safety outcomes in this population is limited. Design/Methods: Using administrative data on admissions to California hospitals between 2005–2011, we performed a cross-sectional study of adult patients admitted with AIS who received IV-tPA. ICD-9-CM codes were used to identify cases and ascertain diagnoses, including ICH subtypes and existing comorbidities. We used multivariable logistic regression to model the odds of in-hospital mortality as a function of previous ICH, adjusting for potential confounders. In post-hoc analysis, we assessed mortality as a function of IV-tPA administration in patients admitted with AIS who had history of ICH. Results: Among 372,167 admissions for AIS during the study period, 10,882 (2.9%) received IV-tPA (mean age 70.6 [SD 14.6], female 5,614 [54.8%]). 268 (2.5%) had prior diagnoses of ICH, including intracerebral hemorrhage, subarachnoid hemorrhage, subdural hemorrhage, and epidural hemorrhage. Mortality was 12.2% overall, 11.7% for patients without history of ICH, and 31.0% for patients with history of ICH (p Conclusions: In a large sample of patients admitted with AIS who received IV-tPA, history of ICH was independently associated with significantly increased mortality. Future efforts should be directed towards identifying possible subgroups in whom IV-tPA may be safe. Disclosure: Dr. Chu has nothing to disclose. Dr. Sommaruga has nothing to disclose. Dr. Hwang has nothing to disclose. Dr. Dearborn has nothing to disclose. Dr. Sansing has nothing to disclose. Dr. Cord has nothing to disclose. Dr. Samarth has nothing to disclose. Dr. Petersen has nothing to disclose. Dr Gilmore has nothing to disclose. Dr. Schindler has nothing to disclose. Dr. Matouk has nothing to disclose. Dr. Sheth has nothing to disclose. Dr Falcone has nothing to disclose." @default.
- W2896495819 created "2018-10-26" @default.
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- W2896495819 date "2018-04-10" @default.
- W2896495819 modified "2023-09-26" @default.
- W2896495819 title "Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033)" @default.
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