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- W2896498638 abstract "G protein-coupled receptor 55 (GPR55) is highly expressed in brain and peripheral nervous system. Originally deorphanized as a cannabinoid receptor, recently GPR55 has been described as a lysophospholipid-responsive receptor, specifically toward lysophosphatidylinositol and lysophosphatidyl-β-d-glucoside (LysoPtdGlc). To characterize lysolipid-GPR55 interaction, synthetic access to LysoPtdGlc and selected analogues was established utilizing a phosphorus(III)-based chemical approach. The biological activity of each synthetic lipid was assessed using a GPR55-dependent chemotropism assay in primary sensory neurons. Combined with molecular dynamics simulations the potential ligand entry port and binding pocket specifics are discussed. These results highlight the preference for gluco- over inositol- and galacto-configured headgroups." @default.
- W2896498638 created "2018-10-26" @default.
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- W2896498638 date "2018-10-15" @default.
- W2896498638 modified "2023-10-14" @default.
- W2896498638 title "Preference for Glucose over Inositol Headgroup during Lysolipid Activation of G Protein-Coupled Receptor 55" @default.
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- W2896498638 doi "https://doi.org/10.1021/acschemneuro.8b00505" @default.
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