FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896498740> ?p ?o ?g. }

• W2896498740 endingPage "18.2018" @default.
• W2896498740 startingPage "ENEURO.0272" @default.
• W2896498740 abstract "<h3>Abstract</h3> The basolateral amygdala complex, which contains the lateral (LA) and basal (BA) subnuclei, is a critical substrate of associative learning related to reward and aversive stimuli. Auditory fear conditioning studies in rodents have shown that the excitation of LA pyramidal neurons, driven by the inhibition of local GABAergic interneurons, is critical to fear memory formation. Studies examining the role of the BA in auditory fear conditioning, however, have yielded divergent outcomes. Here, we used a neuron-specific chemogenetic approach to manipulate the excitability of mouse BA neurons during auditory fear conditioning. We found that chemogenetic inhibition of BA GABA neurons, but not BA pyramidal neurons, impaired fear learning. Further, either chemogenetic stimulation of BA GABA neurons or chemogenetic inhibition of BA pyramidal neurons was sufficient to generate the formation of an association between a behavior and a neutral auditory cue. This chemogenetic memory required presentation of a discrete cue, and was not attributable to an effect of BA pyramidal neuron inhibition on general freezing behavior, locomotor activity, or anxiety. Collectively, these data suggest that BA GABA neuron activation and the subsequent inhibition of BA pyramidal neurons play important role in fear learning. Moreover, the roles of inhibitory signaling differ between the LA and BA, with excitation of pyramidal neurons promoting memory formation in the former, and inhibition of pyramidal neurons playing this role in the latter." @default.
• W2896498740 created "2018-10-26" @default.
• W2896498740 creator A5013708097 @default.
• W2896498740 creator A5050774548 @default.
• W2896498740 creator A5054992094 @default.
• W2896498740 creator A5091599894 @default.
• W2896498740 date "2018-09-01" @default.
• W2896498740 modified "2023-10-11" @default.
• W2896498740 title "Inhibition of Pyramidal Neurons in the Basal Amygdala Promotes Fear Learning" @default.
• W2896498740 cites W110477265 @default.
• W2896498740 cites W1480459594 @default.
• W2896498740 cites W1562182300 @default.
• W2896498740 cites W1647216185 @default.
• W2896498740 cites W1732039026 @default.
• W2896498740 cites W1963723820 @default.
• W2896498740 cites W1965534328 @default.
• W2896498740 cites W1966403223 @default.
• W2896498740 cites W1989757714 @default.
• W2896498740 cites W1989982790 @default.
• W2896498740 cites W1993585167 @default.
• W2896498740 cites W2002978772 @default.
• W2896498740 cites W2007542077 @default.
• W2896498740 cites W2010367567 @default.
• W2896498740 cites W2011200277 @default.
• W2896498740 cites W2014445283 @default.
• W2896498740 cites W2017586792 @default.
• W2896498740 cites W2026720425 @default.
• W2896498740 cites W2028191505 @default.
• W2896498740 cites W2028819787 @default.
• W2896498740 cites W2030513087 @default.
• W2896498740 cites W2031142338 @default.
• W2896498740 cites W2031471928 @default.
• W2896498740 cites W2040574649 @default.
• W2896498740 cites W2042479971 @default.
• W2896498740 cites W2044686824 @default.
• W2896498740 cites W2054950553 @default.
• W2896498740 cites W2062573109 @default.
• W2896498740 cites W2075312117 @default.
• W2896498740 cites W2076445235 @default.
• W2896498740 cites W2079935199 @default.
• W2896498740 cites W2080274555 @default.
• W2896498740 cites W2085752437 @default.
• W2896498740 cites W2089767272 @default.
• W2896498740 cites W2089927455 @default.
• W2896498740 cites W2090654839 @default.
• W2896498740 cites W2092568693 @default.
• W2896498740 cites W2104135721 @default.
• W2896498740 cites W2113064032 @default.
• W2896498740 cites W2117445750 @default.
• W2896498740 cites W2123717940 @default.
• W2896498740 cites W2125252313 @default.
• W2896498740 cites W2125347383 @default.
• W2896498740 cites W2128258712 @default.
• W2896498740 cites W2133659563 @default.
• W2896498740 cites W2138098510 @default.
• W2896498740 cites W2140201388 @default.
• W2896498740 cites W2141674392 @default.
• W2896498740 cites W2146421584 @default.
• W2896498740 cites W2152435789 @default.
• W2896498740 cites W2158553737 @default.
• W2896498740 cites W2159887581 @default.
• W2896498740 cites W2160263248 @default.
• W2896498740 cites W2161437069 @default.
• W2896498740 cites W2171343069 @default.
• W2896498740 cites W2265810207 @default.
• W2896498740 cites W2275148408 @default.
• W2896498740 cites W2318838494 @default.
• W2896498740 cites W2326092449 @default.
• W2896498740 cites W2327332446 @default.
• W2896498740 cites W2570948019 @default.
• W2896498740 cites W2581776140 @default.
• W2896498740 cites W2607528746 @default.
• W2896498740 cites W2774086317 @default.
• W2896498740 cites W2784903304 @default.
• W2896498740 cites W339994169 @default.
• W2896498740 cites W4211021876 @default.
• W2896498740 cites W654134963 @default.
• W2896498740 doi "https://doi.org/10.1523/eneuro.0272-18.2018" @default.
• W2896498740 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6220591" @default.
• W2896498740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30406197" @default.
• W2896498740 hasPublicationYear "2018" @default.
• W2896498740 type Work @default.
• W2896498740 sameAs 2896498740 @default.
• W2896498740 citedByCount "17" @default.
• W2896498740 countsByYear W28964987402019 @default.
• W2896498740 countsByYear W28964987402020 @default.
• W2896498740 countsByYear W28964987402021 @default.
• W2896498740 countsByYear W28964987402022 @default.
• W2896498740 countsByYear W28964987402023 @default.
• W2896498740 crossrefType "journal-article" @default.
• W2896498740 hasAuthorship W2896498740A5013708097 @default.
• W2896498740 hasAuthorship W2896498740A5050774548 @default.
• W2896498740 hasAuthorship W2896498740A5054992094 @default.
• W2896498740 hasAuthorship W2896498740A5091599894 @default.
• W2896498740 hasBestOaLocation W28964987401 @default.
• W2896498740 hasConcept C100798922 @default.
• W2896498740 hasConcept C15744967 @default.
• W2896498740 hasConcept C16837860 @default.

• next