Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896511300> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2896511300 endingPage "1248" @default.
- W2896511300 startingPage "1240" @default.
- W2896511300 abstract "Thirty-one Cephalosporin compounds were modeled using the multivariate image analysis and applied to the quantitative structure activity relationship (MIA-QSAR) approach. The acid dissociation constants (pKa) of cephalosporins play a fundamental role in the mechanism of activity of cephalosporins. The antimicrobial activity of cephalosporins was related to their first pKa by different models. Bidimensional molecular structures (images) were used to calculate some pixel descriptors. The selection of pixels by successive projections algorithm (SPA) was done to achieve simple MIA-QSAR models; based on a small subset of pixels. In the present study, the performance of pixel selection technique using SPA for partial least squares (PLS) model was evaluated. The obtained model showed nice prediction ability with root mean square error of prediction (RMSEP) values of 0.402, 0.315, and 0.160 for principal component regression (PCR), PLS and SPA-PLS models respectively. Among the three methods, SPA-PLS was potentially useful in predicting the pKa of cephalosporins. The study showed the maximum structural efficacy is on pKa in a, b and c regions." @default.
- W2896511300 created "2018-10-26" @default.
- W2896511300 creator A5031112788 @default.
- W2896511300 creator A5054574059 @default.
- W2896511300 creator A5064558274 @default.
- W2896511300 creator A5070048483 @default.
- W2896511300 date "2018-01-01" @default.
- W2896511300 modified "2023-09-23" @default.
- W2896511300 title "Pixel Selection by Successive Projections Algorithm Method in Multivariate Image Analysis for a QSAR Study of Antimicrobial Activity for Cephalosporins and Design New Cephalosporins." @default.
- W2896511300 cites W1966647593 @default.
- W2896511300 cites W1972794452 @default.
- W2896511300 cites W1977513226 @default.
- W2896511300 cites W1992090646 @default.
- W2896511300 cites W1997731847 @default.
- W2896511300 cites W2017281520 @default.
- W2896511300 cites W2026933652 @default.
- W2896511300 cites W2069503191 @default.
- W2896511300 cites W2104491231 @default.
- W2896511300 cites W2170126751 @default.
- W2896511300 cites W2289557006 @default.
- W2896511300 cites W2297314529 @default.
- W2896511300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6269580" @default.
- W2896511300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30568684" @default.
- W2896511300 hasPublicationYear "2018" @default.
- W2896511300 type Work @default.
- W2896511300 sameAs 2896511300 @default.
- W2896511300 citedByCount "0" @default.
- W2896511300 crossrefType "journal-article" @default.
- W2896511300 hasAuthorship W2896511300A5031112788 @default.
- W2896511300 hasAuthorship W2896511300A5054574059 @default.
- W2896511300 hasAuthorship W2896511300A5064558274 @default.
- W2896511300 hasAuthorship W2896511300A5070048483 @default.
- W2896511300 hasConcept C105795698 @default.
- W2896511300 hasConcept C119857082 @default.
- W2896511300 hasConcept C153180895 @default.
- W2896511300 hasConcept C154945302 @default.
- W2896511300 hasConcept C161584116 @default.
- W2896511300 hasConcept C164126121 @default.
- W2896511300 hasConcept C185592680 @default.
- W2896511300 hasConcept C22354355 @default.
- W2896511300 hasConcept C27438332 @default.
- W2896511300 hasConcept C33923547 @default.
- W2896511300 hasConcept C41008148 @default.
- W2896511300 hasConcept C501593827 @default.
- W2896511300 hasConcept C55493867 @default.
- W2896511300 hasConcept C64778159 @default.
- W2896511300 hasConcept C74887250 @default.
- W2896511300 hasConceptScore W2896511300C105795698 @default.
- W2896511300 hasConceptScore W2896511300C119857082 @default.
- W2896511300 hasConceptScore W2896511300C153180895 @default.
- W2896511300 hasConceptScore W2896511300C154945302 @default.
- W2896511300 hasConceptScore W2896511300C161584116 @default.
- W2896511300 hasConceptScore W2896511300C164126121 @default.
- W2896511300 hasConceptScore W2896511300C185592680 @default.
- W2896511300 hasConceptScore W2896511300C22354355 @default.
- W2896511300 hasConceptScore W2896511300C27438332 @default.
- W2896511300 hasConceptScore W2896511300C33923547 @default.
- W2896511300 hasConceptScore W2896511300C41008148 @default.
- W2896511300 hasConceptScore W2896511300C501593827 @default.
- W2896511300 hasConceptScore W2896511300C55493867 @default.
- W2896511300 hasConceptScore W2896511300C64778159 @default.
- W2896511300 hasConceptScore W2896511300C74887250 @default.
- W2896511300 hasIssue "4" @default.
- W2896511300 hasLocation W28965113001 @default.
- W2896511300 hasOpenAccess W2896511300 @default.
- W2896511300 hasPrimaryLocation W28965113001 @default.
- W2896511300 hasRelatedWork W1984782748 @default.
- W2896511300 hasRelatedWork W1996048108 @default.
- W2896511300 hasRelatedWork W2025388239 @default.
- W2896511300 hasRelatedWork W2054246399 @default.
- W2896511300 hasRelatedWork W2054758007 @default.
- W2896511300 hasRelatedWork W2060925218 @default.
- W2896511300 hasRelatedWork W2098000732 @default.
- W2896511300 hasRelatedWork W2136007029 @default.
- W2896511300 hasRelatedWork W2366600326 @default.
- W2896511300 hasRelatedWork W2806587169 @default.
- W2896511300 hasVolume "17" @default.
- W2896511300 isParatext "false" @default.
- W2896511300 isRetracted "false" @default.
- W2896511300 magId "2896511300" @default.
- W2896511300 workType "article" @default.